Any has used this before: Picrorhiza Kurroa Extract (Picroliv® 4% kutkin )
Chemical Constituents and Components : Main chemical constituents are glycosides picroside I, II and III, picrorhizin, kutkoside, kurrin, kuthinol, kutkiol, kutkisterol, kutkoside, androsin, apocynin, drosin and cucurbitacin.
Bitters / Kutkin:
1. It alters the structure of the outer membrane of the hepatocytes in such a way as to prevent penetration of the liver toxin into the interior of the cell.
2. It stimulates the action of nucleolar polymerase A, resulting in ribosomal protein synthesis and, thus stimulates the regenerative ability of the liver and formation of new hepatocytes.
3. It exhibits anti-inflammatory action on a variety of inflammatory models.
4. It modulates liver enzyme level.
5. It decreases level of lipid peroxidases and hydroperoxidases, free radical producing agents.
6. It shows curative activity against hepatotoxins like thioacetamide, galaclosamine and carbontetrachloride.
Curing Diseases :
1. It is antibacterial and anti-inflammatory in action.
2. It is useful in curing fever and stomach disorders.
3. It shows hepatoprotective properties and protects liver against toxins.
4. It shows antioxidant activity.
5. It is used to lowers the high cholesterol level.
Research Information : Ethanol extract of rhizome of Picrorhiza kurroa, at a dose of 20gm/kg body weight, accelerated the healing of stomach wall of indomethacin induced gastric ulcers patients. (Ray, Arun and et.al., Antioxidant activity of Rhizome of Picrorhiza kurroa on healing, Indian Journal of Clinical Biochemistry, 2002, 17(2) 44-51)
Kutkin vs. :
Kutkin- A Review of Chemistry and Pharmacology
Silymarin is a well-known hepatoprotective agent. Silymarin is a flavonol- lignan mixture obtained from seeds of Silybum marianum. Silymarin is a mixture of silybin, isosilybin, silychristin and silydianin. Silybin A and B are collectively known as silibinin. Randomized, controlled trials have proved efficacy of silymarin in liver diseases.
Picrorhiza kurroa, when compared with silymarin, the hepatoprotective effect of Picrorhiza kurroa was found to be similar, or in many cases, superior to the effect of Silybum marianum.