Natural PDE5 Inhibitors?
- 07-16-2010, 04:06 PM
- 07-16-2010, 04:07 PM
do you mean stuff to get boners?
The difference between who you are and who you want to be is what you do.
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- 07-16-2010, 05:32 PM
Yea ED drugs are PDE-5 inhibitors. So he is looking for a herbal viagra.
- 07-16-2010, 05:39 PM
Icariin should fit the bill perfectly. Heard the taste is worser than CEE at a 20% extract, wondering wether it might be worthwhile getting some still in bulk form or not lol
- 07-16-2010, 05:52 PM
Was just reading another thread on another board this. Member Ex Dubio posted this:
Based on this paper, the IC50 of sildenafil is 0.42 and the IC50 of icariin is 4.62 for PDE5 inhibition. Thus the dose of icarrin should be approximately ten times a given dose of sildenafil, thus approximately 250mg-1g for typical use.
But icariin has also been shown to have long-term effects on increasing erectile function through eNOS modulation, as I recall. So for long-term use, you may never need to use a dose that is quite so high.
At any rate, you're looking at taking about 1-2g of a 20% extract to see substantial short-term effects. It has essentially no side effects of toxicities that I am aware of, for what it's worth. I was fairly impressed with the 20% from 1fast400, but I'm sure there are better sources.
If you used an extract not standardized for icariin, by the way, you might as well be using a placebo. -
- 07-17-2010, 10:19 AM
- 07-17-2010, 11:13 AM
- 07-17-2010, 07:19 PM
We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....
try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects rival pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressureDirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals - 07-17-2010, 09:32 PM
- 07-17-2010, 09:48 PM
On Thermogum's site they've got a 50% extract in capsule form (500mg/cap, 100caps)
http://www.thermogum.com/TGSub50x37x1x10021.aspx"I am legally blind and if I can Squat,deadlift and over all get myself to the gym then anyone can get their a$$ in gear and get strong!!" - malleus25
WHITE WHALE! - 07-18-2010, 10:07 PM
- 07-20-2010, 12:14 PM
- 07-20-2010, 01:05 PM
- 07-20-2010, 02:00 PM
Yes and no- the effect "down there" seems to be much more pronounced with the pharma PDE5 inhibitors, but as far as peripheral vasodilation, highly extracted icariin definitely shines. Icariin at the dosages that I mentioned will also have an effect in the aforementioned region, albeit not as strong as slidenafil or taladafil.....
Interestingly enough- you will actually get visual disturbances at much lower relative dosages from high doses of icariin than pharmaceutical PDE5 inhibitors. These compounds are very efficient at increasing intraocular pressure (part of the peripheral vasodilating effect)- you have to be careful when dosing themDirk Tanis, BA, MSci
Chief Operating Officer, Applied Nutriceuticals - 07-20-2010, 06:16 PM
- 07-20-2010, 10:38 PM
- 07-21-2010, 03:20 PM
- 07-23-2010, 07:31 AM
- 07-23-2010, 10:37 AM
- 07-23-2010, 11:07 AM
- 07-23-2010, 01:11 PM
- 07-23-2010, 01:23 PM
- 07-23-2010, 09:59 PM
- 07-24-2010, 02:09 PM
I disagree. I agree with your overall concept, but if someone could produce an OTC PDE5 inhibitor, they would be a million dollar supplement company overnight. The biggest problem is that pharma companies would lobby to get it banned, wouldnt want to cut profits out of viagra/cialis profits.
- 07-25-2010, 04:37 AM
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