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Natural PDE5 Inhibitors?

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    Natural PDE5 Inhibitors?


    What are some natural PDE5 Inhibitors/Blockers? Are their any foods/drinks/supplements/vitamins/etc... that can be taken to inhibit PDE-5?

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    do you mean stuff to get boners?
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    Yea ED drugs are PDE-5 inhibitors. So he is looking for a herbal viagra.
    Just inject.
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    Icariin should fit the bill perfectly. Heard the taste is worser than CEE at a 20% extract, wondering wether it might be worthwhile getting some still in bulk form or not lol
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    Was just reading another thread on another board this. Member Ex Dubio posted this:

    Based on this paper, the IC50 of sildenafil is 0.42 and the IC50 of icariin is 4.62 for PDE5 inhibition. Thus the dose of icarrin should be approximately ten times a given dose of sildenafil, thus approximately 250mg-1g for typical use.

    But icariin has also been shown to have long-term effects on increasing erectile function through eNOS modulation, as I recall. So for long-term use, you may never need to use a dose that is quite so high.

    At any rate, you're looking at taking about 1-2g of a 20% extract to see substantial short-term effects. It has essentially no side effects of toxicities that I am aware of, for what it's worth. I was fairly impressed with the 20% from 1fast400, but I'm sure there are better sources.

    If you used an extract not standardized for icariin, by the way, you might as well be using a placebo.
    There's also research chem for the synthetic PDE-5s
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    Icariin, isn't that Horny Goat Weed?
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    Quote Originally Posted by Z28Luver7777 View Post
    Icariin, isn't that Horny Goat Weed?
    Its from Horny Goat Weed, yes. Its the active that HGW is standardized for.
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    Quote Originally Posted by WilteredFire View Post
    Its from Horny Goat Weed, yes. Its the active that HGW is standardized for.
    We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....

    try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects ***** pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressure
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
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    Quote Originally Posted by rms80 View Post
    We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....

    try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects ***** pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressure
    where can you get this stuff?
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    On Thermogum's site they've got a 50% extract in capsule form (500mg/cap, 100caps)

    http://www.thermogum.com/TGSub50x37x1x10021.aspx
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    Quote Originally Posted by Z28Luver7777 View Post
    where can you get this stuff?
    Some of the bulk powder sites had 40 or 50% icariin- Nutra had it for a while- not sure if they still have it or not- they were selling it in 50 gram increments.....
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
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    Quote Originally Posted by rms80 View Post
    We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....

    try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects ***** pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressure
    Would you say that the effects are similar to the pharmaceutical PDE5 inhibitors or doesn't come close?
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    Arginine.
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    Quote Originally Posted by Z28Luver7777 View Post
    Would you say that the effects are similar to the pharmaceutical PDE5 inhibitors or doesn't come close?
    Yes and no- the effect "down there" seems to be much more pronounced with the pharma PDE5 inhibitors, but as far as peripheral vasodilation, highly extracted icariin definitely shines. Icariin at the dosages that I mentioned will also have an effect in the aforementioned region, albeit not as strong as slidenafil or taladafil.....

    Interestingly enough- you will actually get visual disturbances at much lower relative dosages from high doses of icariin than pharmaceutical PDE5 inhibitors. These compounds are very efficient at increasing intraocular pressure (part of the peripheral vasodilating effect)- you have to be careful when dosing them
    Dirk Tanis, BA, MSci
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    Quote Originally Posted by rms80 View Post
    Yes and no- the effect "down there" seems to be much more pronounced with the pharma PDE5 inhibitors, but as far as peripheral vasodilation, highly extracted icariin definitely shines. Icariin at the dosages that I mentioned will also have an effect in the aforementioned region, albeit not as strong as slidenafil or taladafil.....

    Interestingly enough- you will actually get visual disturbances at much lower relative dosages from high doses of icariin than pharmaceutical PDE5 inhibitors. These compounds are very efficient at increasing intraocular pressure (part of the peripheral vasodilating effect)- you have to be careful when dosing them
    Awesome Thank You!

    Has anyone else tried both Icariin and slidenafil or taladafil. Which do you prefer? and Why? Thank You
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    Quote Originally Posted by wastedwhiteboy2 View Post
    Arginine.
    Not targeted enough I don't think?
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    Best natural PDE5 inhibitor: Xanthoparmelia Scabrosa 50% Piperizine (google it)
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    Quote Originally Posted by JoeHT View Post
    Best natural PDE5 inhibitor: Xanthoparmelia Scabrosa 50% Piperizine (google it)
    There is nothing on pubmed proving this. Is there any science to back it, or just a lot of anecdote?
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    Quote Originally Posted by Robboe View Post
    There is nothing on pubmed proving this. Is there any science to back it, or just a lot of anecdote?
    I only saw information on sites attempting to sell the product as well. PubMed, nothing...
    Just inject.
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    Quote Originally Posted by HereToStudy View Post
    I only saw information on sites attempting to sell the product as well. PubMed, nothing...
    Maybe clinical science hasn't caught up to it yet. No doubt there is a ton of awesome compounds that are well known locally around the world that have yet to reach the research stage.
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    Quote Originally Posted by Robboe View Post
    There is nothing on pubmed proving this. Is there any science to back it, or just a lot of anecdote?
    Just based on my personal experience, having tried others like Icariin 50%.

    BTW, it works even better stacked with Cnidium Monnier 50% Osthole.
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    Quote Originally Posted by JoeHT View Post
    Just based on my personal experience, having tried others like Icariin 50%.

    BTW, it works even better stacked with Cnidium Monnier 50% Osthole.
    The research on osthol helping to relax the corpus cavernosum is pretty decent.
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    Quote Originally Posted by Robboe View Post
    Maybe clinical science hasn't caught up to it yet. No doubt there is a ton of awesome compounds that are well known locally around the world that have yet to reach the research stage.
    Some probably won't ever make it because money can't be made on them, unfortunate how that works .
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    Quote Originally Posted by BamaDog View Post
    Some probably won't ever make it because money can't be made on them, unfortunate how that works .
    I disagree. I agree with your overall concept, but if someone could produce an OTC PDE5 inhibitor, they would be a million dollar supplement company overnight. The biggest problem is that pharma companies would lobby to get it banned, wouldnt want to cut profits out of viagra/cialis profits.
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    Quote Originally Posted by HereToStudy View Post
    I disagree. I agree with your overall concept, but if someone could produce an OTC PDE5 inhibitor, they would be a million dollar supplement company overnight. The biggest problem is that pharma companies would lobby to get it banned, wouldnt want to cut profits out of viagra/cialis profits.
    Agreed, unfortunately the big pharmaceutical companies rule and would squash any potential competitor in an instant.
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    Quote Originally Posted by Robboe View Post
    The research on osthol helping to relax the corpus cavernosum is pretty decent.
    Osthole has some pretty good research to go along with it- but it has some really unpleasant sides in some people. I was looking at putting it in one of our products, and actually had to stop multiple versions of a new product testing trial because of it- several testers had really bad nausea and headaches. We couldn't figure out what was causing the issues at first- we originally thought it was an interaction between two other ingredients- but when we took them out, the issues continued- so we finally narrowed it down to the osthole
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    Quote Originally Posted by JoeHT View Post
    Just based on my personal experience, having tried others like Icariin 50%.

    BTW, it works even better stacked with Cnidium Monnier 50% Osthole.
    Where can i get Cnidium Monnier 50% Osthole?
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    Quote Originally Posted by rms80 View Post
    Osthole has some pretty good research to go along with it- but it has some really unpleasant sides in some people. I was looking at putting it in one of our products, and actually had to stop multiple versions of a new product testing trial because of it- several testers had really bad nausea and headaches. We couldn't figure out what was causing the issues at first- we originally thought it was an interaction between two other ingredients- but when we took them out, the issues continued- so we finally narrowed it down to the osthole
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    Quote Originally Posted by UKStrength View Post
    Agreed, unfortunately the big pharmaceutical companies rule and would squash any potential competitor in an instant.
    Isn't that what happened with the original Aspire36
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    Yeah, I get really bad sides from Ostole. I took pSarm and felt like I was going to die.. Like I needed to throw up but couldn't. Bad headache too.
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    Interesting. I get absolutely no side effects from Ostole. Now, with Scabrosa sometimes I get insomnia.
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    Quote Originally Posted by Z28Luver7777 View Post
    Isn't that what happened with the original Aspire36
    The FDA found an analog of viagra in it.
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    Thinking of getting myself some 45% Icariin extract, about 3 months supply and doing a continous run at 1gram per day specifically for Libido increasing properties. Any extra benefits in performance at the gym will be icing on the cake. Looking forward to it already.
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    Quote Originally Posted by WilteredFire View Post
    Thinking of getting myself some 45% Icariin extract, about 3 months supply and doing a continous run at 1gram per day specifically for Libido increasing properties. Any extra benefits in performance at the gym will be icing on the cake. Looking forward to it already.
    If you log it, link me to the thread. If not, PM me with your results once you're done. I am genuinely interested in what high dose icariin can do for training and gains.
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    Quote Originally Posted by Robboe View Post
    If you log it, link me to the thread. If not, PM me with your results once you're done. I am genuinely interested in what high dose icariin can do for training and gains.
    Thanks man, theres going to always be other supplements I'll use over the coming months if I took this so Im not sure if a log might be honest of me to put up, however I'll definately PM you my results and experience the best I can.

    I wont forget

    Take care mate
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    Tried Two of the Three...


    Quote Originally Posted by Z28Luver7777 View Post
    Awesome Thank You!

    Has anyone else tried both Icariin and slidenafil or taladafil. Which do you prefer? and Why? Thank You
    I have psychological spontaneous impotence and doubted anything could help... I tried the little blue pill several times with no improvement... I later tried Ci**s and felt nothing UNTIL there was a little erotic stimulation the tingling grew and grew until in a few minuets I had a rock h**d you could poke thru a steel drum... No exagerration... and it lasted over 4 hours and I had complete ejacjulatory controll... This is probably my only post, I only joined so this information might help someone that has suffered as I have from ED... Oh and a little info... Im 58... Was then 55... The 20mg ci**s pill usually gave me a headache and blurry vision... I began cutting it in half and took a half every other day... No headaches, normal vision and the same enhanced performance... goodluck...
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    topical passion parties creams actually have arginine HCL in the formula and its topical so its direct.... but its nota PDE5 inhibitor so no tht refractory eriod bounce back....
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    Aspire 36 original, that was the ****. Pharmas should release that!
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    Quote Originally Posted by Noone58 View Post
    I have psychological spontaneous impotence and doubted anything could help... I tried the little blue pill several times with no improvement... I later tried Ci**s and felt nothing UNTIL there was a little erotic stimulation the tingling grew and grew until in a few minuets I had a rock h**d you could poke thru a steel drum... No exagerration... and it lasted over 4 hours and I had complete ejacjulatory controll... This is probably my only post, I only joined so this information might help someone that has suffered as I have from ED... Oh and a little info... Im 58... Was then 55... The 20mg ci**s pill usually gave me a headache and blurry vision... I began cutting it in half and took a half every other day... No headaches, normal vision and the same enhanced performance... goodluck...
    excellent post
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