Natural PDE5 Inhibitors?

Page 1 of 2 12 Last
  1. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Natural PDE5 Inhibitors?


    What are some natural PDE5 Inhibitors/Blockers? Are their any foods/drinks/supplements/vitamins/etc... that can be taken to inhibit PDE-5?

  2. Registered User
    rochabp's Avatar
    Stats
    5'8"  205 lbs.
    Join Date
    May 2009
    Posts
    5,190
    Rep Power
    216443

    do you mean stuff to get boners?
    The difference between who you are and who you want to be is what you do.
  3. Primordial Performance Rep
    Board Sponsor
    HereToStudy's Avatar
    Stats
    6'0"  208 lbs.
    Join Date
    Dec 2009
    Location
    Chicago
    Posts
    9,390
    Rep Power
    235106

    Yea ED drugs are PDE-5 inhibitors. So he is looking for a herbal viagra.
    Just inject.
    Facebook:
    www.facebook.com/heretostudy
    •   
       

  4. Registered User
    WilteredFire's Avatar
    Stats
    5'10"  164 lbs.
    Join Date
    Feb 2008
    Location
    England
    Posts
    488
    Rep Power
    326

    Icariin should fit the bill perfectly. Heard the taste is worser than CEE at a 20% extract, wondering wether it might be worthwhile getting some still in bulk form or not lol
  5. Board Sponsor
    Board Sponsor
    GregW's Avatar
    Join Date
    Mar 2010
    Posts
    259
    Rep Power
    186

    Was just reading another thread on another board this. Member Ex Dubio posted this:

    Based on this paper, the IC50 of sildenafil is 0.42 and the IC50 of icariin is 4.62 for PDE5 inhibition. Thus the dose of icarrin should be approximately ten times a given dose of sildenafil, thus approximately 250mg-1g for typical use.

    But icariin has also been shown to have long-term effects on increasing erectile function through eNOS modulation, as I recall. So for long-term use, you may never need to use a dose that is quite so high.

    At any rate, you're looking at taking about 1-2g of a 20% extract to see substantial short-term effects. It has essentially no side effects of toxicities that I am aware of, for what it's worth. I was fairly impressed with the 20% from 1fast400, but I'm sure there are better sources.

    If you used an extract not standardized for icariin, by the way, you might as well be using a placebo.
    There's also research chem for the synthetic PDE-5s
  6. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Icariin, isn't that Horny Goat Weed?
  7. Registered User
    WilteredFire's Avatar
    Stats
    5'10"  164 lbs.
    Join Date
    Feb 2008
    Location
    England
    Posts
    488
    Rep Power
    326

    Quote Originally Posted by Z28Luver7777 View Post
    Icariin, isn't that Horny Goat Weed?
    Its from Horny Goat Weed, yes. Its the active that HGW is standardized for.
  8. Running with the Big Boys
    Board Sponsor
    rms80's Avatar
    Stats
    6'2"  215 lbs.
    Join Date
    Jan 2007
    Location
    Charlotte
    Posts
    4,224
    Rep Power
    204219

    Quote Originally Posted by WilteredFire View Post
    Its from Horny Goat Weed, yes. Its the active that HGW is standardized for.
    We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....

    try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects ***** pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressure
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
  9. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Quote Originally Posted by rms80 View Post
    We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....

    try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects ***** pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressure
    where can you get this stuff?
  10. Registered User
    SilentBob187's Avatar
    Stats
    5'9"  175 lbs.
    Join Date
    Dec 2007
    Location
    North Carolina
    Age
    29
    Posts
    7,853
    Rep Power
    11113

    On Thermogum's site they've got a 50% extract in capsule form (500mg/cap, 100caps)

    http://www.thermogum.com/TGSub50x37x1x10021.aspx
    "I am legally blind and if I can Squat,deadlift and over all get myself to the gym then anyone can get their a$$ in gear and get strong!!" - malleus25
    WHITE WHALE!
  11. Running with the Big Boys
    Board Sponsor
    rms80's Avatar
    Stats
    6'2"  215 lbs.
    Join Date
    Jan 2007
    Location
    Charlotte
    Posts
    4,224
    Rep Power
    204219

    Quote Originally Posted by Z28Luver7777 View Post
    where can you get this stuff?
    Some of the bulk powder sites had 40 or 50% icariin- Nutra had it for a while- not sure if they still have it or not- they were selling it in 50 gram increments.....
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
  12. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Quote Originally Posted by rms80 View Post
    We usually have 50-100 kg of the 40% icariin at any given time in our facility- it is some fun stuff to play around with.....

    try 1 gram of Epimedium standardized for 40% icariin or 500 mg of the 98% icariin if you can get it- I have done some experimenting, and the effects ***** pharmaceutical PDE5 inhibitors- be careful though- if you take too much, you will start seeing all kinds of tracers, spots, etc. b/c of the increase in intraocular pressure
    Would you say that the effects are similar to the pharmaceutical PDE5 inhibitors or doesn't come close?
  13. Board Supporter
    wastedwhiteboy2's Avatar
    Stats
    6'0"  195 lbs.
    Join Date
    Jun 2004
    Location
    USA
    Age
    40
    Posts
    2,986
    Rep Power
    3010

    Arginine.
  14. Running with the Big Boys
    Board Sponsor
    rms80's Avatar
    Stats
    6'2"  215 lbs.
    Join Date
    Jan 2007
    Location
    Charlotte
    Posts
    4,224
    Rep Power
    204219

    Quote Originally Posted by Z28Luver7777 View Post
    Would you say that the effects are similar to the pharmaceutical PDE5 inhibitors or doesn't come close?
    Yes and no- the effect "down there" seems to be much more pronounced with the pharma PDE5 inhibitors, but as far as peripheral vasodilation, highly extracted icariin definitely shines. Icariin at the dosages that I mentioned will also have an effect in the aforementioned region, albeit not as strong as slidenafil or taladafil.....

    Interestingly enough- you will actually get visual disturbances at much lower relative dosages from high doses of icariin than pharmaceutical PDE5 inhibitors. These compounds are very efficient at increasing intraocular pressure (part of the peripheral vasodilating effect)- you have to be careful when dosing them
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
  15. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Quote Originally Posted by rms80 View Post
    Yes and no- the effect "down there" seems to be much more pronounced with the pharma PDE5 inhibitors, but as far as peripheral vasodilation, highly extracted icariin definitely shines. Icariin at the dosages that I mentioned will also have an effect in the aforementioned region, albeit not as strong as slidenafil or taladafil.....

    Interestingly enough- you will actually get visual disturbances at much lower relative dosages from high doses of icariin than pharmaceutical PDE5 inhibitors. These compounds are very efficient at increasing intraocular pressure (part of the peripheral vasodilating effect)- you have to be careful when dosing them
    Awesome Thank You!

    Has anyone else tried both Icariin and slidenafil or taladafil. Which do you prefer? and Why? Thank You
  16. Registered User
    BamaDog's Avatar
    Join Date
    Jul 2010
    Posts
    97
    Rep Power
    456

    Quote Originally Posted by wastedwhiteboy2 View Post
    Arginine.
    Not targeted enough I don't think?
  17. Registered User
    JoeHT's Avatar
    Stats
    5'11"  172 lbs.
    Join Date
    Mar 2010
    Posts
    113
    Rep Power
    21616

    Best natural PDE5 inhibitor: Xanthoparmelia Scabrosa 50% Piperizine (google it)
  18. Handsome and intelligent
    Board Sponsor
    Robboe's Avatar
    Join Date
    Mar 2005
    Location
    Schivatzia
    Posts
    4,927
    Rep Power
    8378

    Quote Originally Posted by JoeHT View Post
    Best natural PDE5 inhibitor: Xanthoparmelia Scabrosa 50% Piperizine (google it)
    There is nothing on pubmed proving this. Is there any science to back it, or just a lot of anecdote?
    The Driven Blog
    Follow DS on Facebook and Twitter!

    Craze™ is NOW AVAILABLE!
  19. Primordial Performance Rep
    Board Sponsor
    HereToStudy's Avatar
    Stats
    6'0"  208 lbs.
    Join Date
    Dec 2009
    Location
    Chicago
    Posts
    9,390
    Rep Power
    235106

    Quote Originally Posted by Robboe View Post
    There is nothing on pubmed proving this. Is there any science to back it, or just a lot of anecdote?
    I only saw information on sites attempting to sell the product as well. PubMed, nothing...
    Just inject.
    Facebook:
    www.facebook.com/heretostudy
  20. Handsome and intelligent
    Board Sponsor
    Robboe's Avatar
    Join Date
    Mar 2005
    Location
    Schivatzia
    Posts
    4,927
    Rep Power
    8378

    Quote Originally Posted by HereToStudy View Post
    I only saw information on sites attempting to sell the product as well. PubMed, nothing...
    Maybe clinical science hasn't caught up to it yet. No doubt there is a ton of awesome compounds that are well known locally around the world that have yet to reach the research stage.
    The Driven Blog
    Follow DS on Facebook and Twitter!

    Craze™ is NOW AVAILABLE!
  21. Registered User
    JoeHT's Avatar
    Stats
    5'11"  172 lbs.
    Join Date
    Mar 2010
    Posts
    113
    Rep Power
    21616

    Quote Originally Posted by Robboe View Post
    There is nothing on pubmed proving this. Is there any science to back it, or just a lot of anecdote?
    Just based on my personal experience, having tried others like Icariin 50%.

    BTW, it works even better stacked with Cnidium Monnier 50% Osthole.
  22. Handsome and intelligent
    Board Sponsor
    Robboe's Avatar
    Join Date
    Mar 2005
    Location
    Schivatzia
    Posts
    4,927
    Rep Power
    8378

    Quote Originally Posted by JoeHT View Post
    Just based on my personal experience, having tried others like Icariin 50%.

    BTW, it works even better stacked with Cnidium Monnier 50% Osthole.
    The research on osthol helping to relax the corpus cavernosum is pretty decent.
    The Driven Blog
    Follow DS on Facebook and Twitter!

    Craze™ is NOW AVAILABLE!
  23. Registered User
    BamaDog's Avatar
    Join Date
    Jul 2010
    Posts
    97
    Rep Power
    456

    Quote Originally Posted by Robboe View Post
    Maybe clinical science hasn't caught up to it yet. No doubt there is a ton of awesome compounds that are well known locally around the world that have yet to reach the research stage.
    Some probably won't ever make it because money can't be made on them, unfortunate how that works .
  24. Primordial Performance Rep
    Board Sponsor
    HereToStudy's Avatar
    Stats
    6'0"  208 lbs.
    Join Date
    Dec 2009
    Location
    Chicago
    Posts
    9,390
    Rep Power
    235106

    Quote Originally Posted by BamaDog View Post
    Some probably won't ever make it because money can't be made on them, unfortunate how that works .
    I disagree. I agree with your overall concept, but if someone could produce an OTC PDE5 inhibitor, they would be a million dollar supplement company overnight. The biggest problem is that pharma companies would lobby to get it banned, wouldnt want to cut profits out of viagra/cialis profits.
  25. UKStrength
    Guest
    UKStrength's Avatar

    Quote Originally Posted by HereToStudy View Post
    I disagree. I agree with your overall concept, but if someone could produce an OTC PDE5 inhibitor, they would be a million dollar supplement company overnight. The biggest problem is that pharma companies would lobby to get it banned, wouldnt want to cut profits out of viagra/cialis profits.
    Agreed, unfortunately the big pharmaceutical companies rule and would squash any potential competitor in an instant.
  26. Running with the Big Boys
    Board Sponsor
    rms80's Avatar
    Stats
    6'2"  215 lbs.
    Join Date
    Jan 2007
    Location
    Charlotte
    Posts
    4,224
    Rep Power
    204219

    Quote Originally Posted by Robboe View Post
    The research on osthol helping to relax the corpus cavernosum is pretty decent.
    Osthole has some pretty good research to go along with it- but it has some really unpleasant sides in some people. I was looking at putting it in one of our products, and actually had to stop multiple versions of a new product testing trial because of it- several testers had really bad nausea and headaches. We couldn't figure out what was causing the issues at first- we originally thought it was an interaction between two other ingredients- but when we took them out, the issues continued- so we finally narrowed it down to the osthole
    Dirk Tanis, BA, MSci
    Chief Operating Officer, Applied Nutriceuticals
  27. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Quote Originally Posted by JoeHT View Post
    Just based on my personal experience, having tried others like Icariin 50%.

    BTW, it works even better stacked with Cnidium Monnier 50% Osthole.
    Where can i get Cnidium Monnier 50% Osthole?
  28. Handsome and intelligent
    Board Sponsor
    Robboe's Avatar
    Join Date
    Mar 2005
    Location
    Schivatzia
    Posts
    4,927
    Rep Power
    8378

    Quote Originally Posted by rms80 View Post
    Osthole has some pretty good research to go along with it- but it has some really unpleasant sides in some people. I was looking at putting it in one of our products, and actually had to stop multiple versions of a new product testing trial because of it- several testers had really bad nausea and headaches. We couldn't figure out what was causing the issues at first- we originally thought it was an interaction between two other ingredients- but when we took them out, the issues continued- so we finally narrowed it down to the osthole
    O'RLY?

    I've only ever researched it, never used it. Thanks for looking out!
    The Driven Blog
    Follow DS on Facebook and Twitter!

    Craze™ is NOW AVAILABLE!
  29. Registered User
    Z28Luver7777's Avatar
    Join Date
    Feb 2010
    Posts
    641
    Rep Power
    98211

    Quote Originally Posted by UKStrength View Post
    Agreed, unfortunately the big pharmaceutical companies rule and would squash any potential competitor in an instant.
    Isn't that what happened with the original Aspire36
  30. Registered User
    underthesun's Avatar
    Stats
    6'0"  205 lbs.
    Join Date
    Jun 2010
    Location
    Beverly Hills, CA
    Posts
    118
    Rep Power
    983

    Yeah, I get really bad sides from Ostole. I took pSarm and felt like I was going to die.. Like I needed to throw up but couldn't. Bad headache too.
  •   

      
     

Similar Forum Threads

  1. Natural Prolactin Inhibitors?
    By Z28Luver7777 in forum Nutrition / Health
    Replies: 43
    Last Post: 02-05-2012, 10:17 AM
  2. Natural COX-2 inhibitors to avoid while on X-Factor
    By Neil5585 in forum Supplements
    Replies: 5
    Last Post: 01-24-2008, 12:52 PM
  3. Aromatace inhibitors vs. suicide inhibitors
    By Headdoc in forum Male Anti-Aging Medicine
    Replies: 6
    Last Post: 07-25-2007, 09:22 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in