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Forskolin up-regulates aromatase

nattydisaster said:
Cooper has some things going on at the moment. He will be back next week
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lol Love this site here we have jim & other looking like for weekInvalid Link Removed
 
Relevance to non-oncogenic cell lines? Nil. cAMP is a known second messenger in growth and potentiation of oncogenic cascades. It's similar to the study showing that arachidonic acid would make cancer worse...yes, it would, because certain cancers are associated with high ArA levels.

Further, a trial in women noted no change in estrogen levels
 
mr.cooper69 said:
Relevance to non-oncogenic cell lines? Nil. cAMP is a known second messenger in growth and potentiation of oncogenic cascades. It's similar to the study showing that arachidonic acid would make cancer worse...yes, it would, because certain cancers are associated with high ArA levels.

Further, a trial in women noted no change in estrogen levels
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Wow next week came fast lol


Thabks
 
Using transformed cell lines as a predictor as to what happens in normal can be dangerous. It also wasn't the purpose of their study. They were just trying to see if this cell line was viable or not. Forskolin was just used to figure out a potential mechanism. Whether ingestion of forskolin would achieve these concentrations in vivo and whether it would result in increased estradiol levels in normal tissues isn't known.

What is known that a study in healthy males (not cell lines) showed an increase in testosterone.
 
USPlabsRep said:
Using transformed cell lines as a predictor as to what happens in normal can be dangerous. It also wasn't the purpose of their study. They were just trying to see if this cell line was viable or not. Forskolin was just used to figure out a potential mechanism. Whether ingestion of forskolin would achieve these concentrations in vivo and whether it would result in increased estradiol levels in normal tissues isn't known.

What is known that a study in healthy males (not cell lines) showed an increase in testosterone.
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Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.
 
xhrr said:
Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.
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I posted a link to a study done in healthy males in another thread (it came out last month).
 
xhrr said:
Weren't they overweight though? Not trying to argue it is far and away my favorite compound anecdotally. That could skew results slightly because as they lose weight and abdominal fat test would likely increase.
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The mechanism of T elevation is through the testes and various enzymes
 
mr.cooper69 said:
The mechanism of T elevation is through the testes and various enzymes
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I think he was going for the "higher levels of adipose tissue (% BMI) are correlated with a propensity for higher individual's rates of estrogen as opposed to healthy BF ranges..." Not necessarily speaking in terms of natural test production.

I could be wrong though, he DID go full retard...
 
PalmFist said:
I think he was going for the "higher levels of adipose tissue (% BMI) are correlated with a propensity for higher individual's rates of estrogen as opposed to healthy BF ranges..." Not necessarily speaking in terms of natural test production.

I could be wrong though, he DID go full retard...
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Haha yes that is what I was alluding to all the while completely disregarding the MOA of forskolin. Guise, forgive me.
 
xhrr said:
not necessary
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I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

But the knot is there
 
EBF Inc said:
I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

But the knot is there
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BBB said:
At 100mg it aggravated my gyno
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Wow I didn't know people were experiencing E related side effects, I never had a problem even at 100 mg. Could explain the anabolic effects it has on bone.
 
A AI may not be "necessary" so to speak but if I was taking anything like DAA or forskolin it can be beneficial to stack
 
horizons said:
A AI may not be "necessary" so to speak but if I was taking anything like DAA or forskolin it can be beneficial to stack
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Alphamax uses 50mg 95% Forksolin but we pair it with 75mg Arimistane(among other things), so may be a good option especially if you stack with Forskolin-95 to get high forksolin doses.
 

I can get down w that lol

But then the amount of forskolin will be at like 200-250 lmao. Let me wait on this
 
EBF Inc said:
I dunno about that I went from 50 to 100 and I swear I got a knot behind my nipple. So I hav been usin erase at 3 a day. Helped very slightly. Also on prime nda and anabeta. So anabeta stopped today see what happens

But the knot is there
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I think I may stay at 50mg now lol
 
xhrr said:
Wow I didn't know people were experiencing E related side effects, I never had a problem even at 100 mg. Could explain the anabolic effects it has on bone.
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Generally speaking, anything that elevates T will elevate E in fashion. Now, that is NOT the same as forskolin directly upregulating aromatase
 
I've been on 100mg/day Forskolin-95 for two months

Had my bi-annual bloodwork last Tuesday and my estrogen was 32 ng/dl. 6 months ago, my estrogen was 34 ng/dl (no forskolin used here)

Both blood tests I was not taking any anti-estrogens or test boosters
 
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