You got me wondering, GettngSwole, if constant exposure to yohimbine could upregulate alpha 2 adrenergic receptors in fat cells, making fat burning more difficult. I did a quick search, and found that this effect has been studied in platelets, and indeed alpha 2 blockade ( this is what yohimbine does ) does upregulate those receptors.
This could potentially be red flag regarding topical yohimbine use. I'll see if I can find similar studies in fat cells.
Life Sci 1991;49(8)
L21-5
Effects of chronic alpha 2-adrenoceptor blockade on platelet and lymphocyte adrenoceptor binding in normal volunteers.
Glue P, Payvandi N, Kay G, Elliott JM, Nutt DJ.
Reckitt and Colman Psychopharmacology Unit, School of Medical Sciences, Bristol, UK.
Platelet and lymphocyte adrenoceptor binding was measured in 12 healthy male volunteers before and after 22 days treatment with the alpha 2-adrenoceptor antagonist idazoxan 40 mg tds. Platelet alpha 2-adrenoceptor number assessed by the agonist 3H-UK 14304 [correction of UK 14303] was significantly increased following idazoxan, with a smaller increase in antagonist binding (3H-rauwolscine). Lymphocyte beta-adrenoceptor number was unaltered by idazoxan, although the variance within the sample was significantly increased. Plasma MHPG levels were significantly reduced by chronic idazoxan. These data indicate upregulation of the platelet alpha 2-adrenoceptor in response to chronic blockade and suggest that this may reflect a similar change in presynaptic alpha 2-adrenoceptors which regulate norepinephrine release.
PS Monkeyballs. I just saw your post above. THIS is probably the abstract that would generate a firestorm at Elite