Effects of oral creatine and resistance training on serum myostatin and GASP-1.

  1. New Member
    WORKOUT COACH's Avatar
    Join Date
    Jul 2009
    Rep Power
    Lv. Percent

    Effects of oral creatine and resistance training on serum myostatin and GASP-1.

    More great creatine news

    Mol Cell Endocrinol. 2010 Apr 12;317(1-2):25-30. Epub 2009 Dec 22.

    Effects of oral creatine and resistance training on serum myostatin and GASP-1.
    Saremi A, Gharakhanloo R, Sharghi S, Gharaati MR, Larijani B, Omidfar K.

    Department of Sport Science, Arak University, Arak, Iran.

    Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42+/-2.2 years) were assigned to control (CON), resistance training+placebo (RT+PL) and resistance training+creatine supplementation (RT+CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each session including three sets of 8-10 repetitions at 60-70% of 1 RM for whole-body exercise. Blood sampling, muscular strength testing and body composition analysis (full body DEXA) were performed at 0, 4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction with resistance training lead to greater decreases in serum myostatin (p<0.05), but had not additional effect on GASP-1 (p>0.05). The effects of resistance training on serum levels of myostatin and GASP-1, may explain the increased muscle mass that is amplified by creatine supplementation.

  2. Senior Member
    corsaking's Avatar
    5'8"   lbs.
    Join Date
    Feb 2008
    Rep Power
    Lv. Percent
    Achievements Activity ProPosting Pro

    great news and its good to see a study done on humans and not mice etc

Similar Forum Threads

  1. creatine and myostatin
    By SweetLou321 in forum Supplements
    Replies: 2
    Last Post: 04-05-2011, 10:41 PM
  2. Replies: 2
    Last Post: 06-01-2010, 07:48 PM
  3. Resistance and Resistance cord strength training
    By nightside1234 in forum Training Forum
    Replies: 0
    Last Post: 07-15-2009, 11:22 PM
  4. Creatine Serum (MMusa)
    By Delita420 in forum Supplements
    Replies: 3
    Last Post: 11-19-2008, 07:19 PM
  5. progressive resistance training.
    By yoked317 in forum General Chat
    Replies: 4
    Last Post: 11-05-2008, 04:41 PM
Log in