- 03-24-2010, 05:11 PM
Hey guys! I need some help understanding this study. It says 'addition of D-Asp to testicular tissue acetone powder induced a significant increase of aromatase activity.' The way I see it, D-aspartic acid increases aromatase of testosterone into a form of estrogen. This sounds negative, but all the supplement companies are starting to sell this stuff. Am I understanding the study wrong?
Endogenous testicular D-aspartic acid regulates gonadal aromatase activity in boar.
Lamanna C, Assisi L, Botte V, Di Fiore MM.
Department of Zoology, University of Naples 'Federico II', Naples, Italy.
D-aspartic acid (D-Asp), aromatase enzyme activity and the putative D-Asp involvement on aromatase induction have been studied in the testis of mature boars. The peroxidase-antiperoxidase and the indirect immunofluorescence methods, applied to cryostat and paraffin sections, were used to evaluate D-Asp and aromatase distributions. D-Asp level was dosed by an enzymatic method performed on boar testis extracts. Biochemical aromatase activity was determined by in vitro experiments carried out on testis extracts. D-Asp immunoreactivity was found in Leydig cells, and, to a lesser extent, in germ cells. Analogously, aromatase immunoreactivity was present in Leydig cells, but absent from seminiferous tubule elements. In vitro experiments showed that the addition of D-Asp to testicular tissue acetone powder induced a significant increase of aromatase activity, as assessed by testosterone conversion to 17beta-estradiol. Enzyme Km was not affected by D-Asp (about 25 nM in control and D-Asp added tests). These findings suggest that D-Asp could be involved in the local regulation of aromatase in boar Leydig cells and intervenes in this organ's production of estrogens.
PMID: 16610240 [PubMed - indexed for MEDLINE]
- 03-24-2010, 05:28 PM
It looks that the consensus in all the studies about D-Asp is that it can do both things: increase test AND increase estrogens
Summary. Mammalian testis contains D-aspartic acid (D-Asp), which enhances testosterone production. D-Asp, on other hand, also stimulates 17β-estradiol synthesis in the ovary of some lower vertebrates. We studied boar testis in order to determine if D-Asp intervenes in 17β-estradiol synthesis in the testis of those mammals which produce significant amounts of estrogens as well as testosterone. The boar testis contains D-Asp (40 ± 3.6 nmol/g tissue) which, according to immunohistological techniques, is localized mainly in Leydig cells, and, to a lesser extent, in sustentacular (Sertoli), peritubular and some germ cells. The enzyme P450aromatase is present in Leydig cells and few germ cells. In vitro experiments showed that the addition of D-Asp to testicular tissue extracts induced a significant increase of aromatase activity, as evaluated by testosterone conversion into 17β-estradiol. The enzyme’s Km was not affected by D-Asp (about 25 nM in both control and D-Asp added tests). On the basis of these results we suggest that, as in the ovary, D-Asp is involved in the local control of aromatase activity of boar testis and, therefore, it intervenes in the 17β-estradiol production. In the testis, the D-Asp targets are presumably the Leydig cells, which having also a nuclear estrogen receptor are, in turn, one of the putative targets of the 17β-estradiol that they produce (autocrine effect).
If that is true (and i think that is true, because almost every study say the same: D-Asp increase test AND estrogens), then i don't understand all the recent hype with D-Asp
03-24-2010, 08:55 PM
There is going to be an elevation in E with an elevation of T, just depends on how much it raises the E. Our bodies generally aim to maintain a certain ratio of T:E, so some elevation in E isn't always a bad thing
03-24-2010, 09:07 PM
03-24-2010, 09:11 PM
03-24-2010, 09:20 PM
03-24-2010, 09:54 PM
03-25-2010, 11:38 AM
03-25-2010, 12:56 PM
03-26-2010, 12:30 PM
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