Testosterone supplement causes aggressive prostate cancer
Testosterone supplement causes aggressive prostate cancer
A designer supplement containing hormone ingredients left two men with an aggressive form of prostate cancer, write two researchers from Texas in Clinical Cancer Research. The makers of the supplement had added substances to the product that were not listed on the label.
Which product it is the researchers are not willing to say “for legal reasons”. They do say that each capsule of the supplement contains, according to the label, 100 mg chrysin, 100 mg red deer velvet antler and 60 mg of a ‘proprietary blend’ that contains six prohormones. The six prohormones, which are supposed to convert into testosterone, included -diones and -dioles.
Lab tests showed however that the supplement did not contain the ingredients named. Estradiol and testosterone did show up in the lab tests though. The product probably contained more active ingredients, reading between the lines of the description of the effects. One of the men – a black man aged 51 – had gained nine kilograms of in eleven months. The other man – a white 67-year-old – had gained nearly five kilograms of in six months and noticed that he also had more energy. Taking testosterone orally won’t give you this effect.
Fitness magazines advertise the supplement. The men bought the product online because they wanted more muscles, energy and libido.
After eleven and ten months respectively the men became ill. They both lost a lot of weight. The doctors discovered that the men had prostate cancer. One already had secondaries in his lungs and brains. When the researchers wrote their article the men were still alive, but the disease was still very much present. The two men were given anti-androgens and medicines to block the production of LH.
To gain more certainty as to whether the supplements had caused the disease in the men, the researchers did an experiment with prostate cancer cells. They exposed the cells to the supplement [HDDS below, Ed.] and to testosterone.
The curves in the graph above show the speed at which the prostate cancer cells grew in a concentration of 100 micrograms of supplement per millilitre, and 24 picograms of testosterone per millilitre.
The researchers also did an experiment in which they exposed the cancer cells to the supplement and to the anti-androgen bicalutamide. And this is the most sinister part of the publication.
The graph above shows the vitality of the cancer cells. If you give them an anti-androgen only, their viability decreases. The more androgen effect there is, the quicker the prostate cancer cells grow. If you sabotage the androgen receptor, they die. The curve with the white circles shows this effect.
All the other curves in the graph represent cells that were exposed not only to the supplement but also to the cancer-inhibiting anti-androgen. At first the anti-androgen reduces the vitality of the cancer cells, but after a few days this effect disappears.
"These findings suggest that the HHDS product stimulates prostate cancer cell growth effectively, bypassing the androgen receptor pathway in prostate cancer cells, while also rendering the cancer cells resistant to standard antiandrogen therapy", the researchers write. "The data suggest a second nonandrogenic growth stimulatory effect of the HHDS, resulting in the activation of an alternative growth pathway that effectively bypasses the androgen receptor, causing resistance to the prostate cancer growth inhibitory actions of bicalutamide. To our knowledge, this is a new type of adverse effect from HHDS."
The supplement in question therefore contains unknown substances that not only have an effect on the androgen receptor, but also stimulate cancer cells in some other way too. The substances make the cancer cells less susceptible to the medicines that doctors use to fight prostate cancer.
The supplement is called Teston-6, according to Ergo-log contacts in the supplements world. Immediately after they had uncovered a relationship between prostate cancer and the supplement, the researchers informed the FDA. Teston-6 was removed from the market soon after. The American senator John Breaux tried to get a motion passed to regulate products like Teston-6, but the terrorist attacks of 9/11 intervened. [quackwatch.com September 10, 2001]
Clinical Cancer Research 14, 607-611, January 15, 2008.
thats a bunch of bs anyhow. No "proof" the androgens caused it, just (gasp) evidence that the cancer cells grew faster when exposed to it. Well gee, same thing if they were exposed to testosterone or growth hormone or any of a number of things. One out of 4 men end up with prostate cancer, and more in the case of black men. So the odds of 2 men with prostate cancer having used the same supplement isn't much of a stretch.
And it coming from ergo-log is less of a stretch, they are an entertainment site, not a factual site. They search for the most extreme stories they can find, and stretch them as much as they can to make them sound even more interesting.
regardless if it's true or not... it's still bad publicity for the supplement industry, which plays right into the hands of the lobbyists for FDA regulating supps.
but on the other hand i googled teston-6 and nothing came up besides this article and the supposed research. no where to buy, what it is, no company name-nothing. now tell me another supplement you can google and NO information about the product comes up. i call horsesheit!
andOf course, the work does not necessarily establish causality between the HHDS and prostate cancer development or growth promotion. We also don't know if the concentrations of the supplement used in cell culture are even achievable in patients taking the supplement.
Which was my exact pointHowever, the title of the Reuters report misrepresents the study: "Natural" supplements caused cancer in 2 men: study. In no way did the authors claim causation. The Consumerist is also guilty of misrepresentation: Hormone-Filled Dietary Supplement Caused Cancer In Two Men, Say Doctors. No, the doctors did not say that.
In contrast, the original press release for the story from UT-Southwestern (shown here from EurekAlert!) responsibly promotes the significance of the work by their researchers, Hormonal dietary supplements might promote prostate cancer progression. Hence, the overinterpretation of the study was not driven by the sensationalism of the press release; rather, these two aforementioned media outlets sensationalized the press releases and the authors,
"Testosterone supplement destroys aggressive prostate cancer"
Would have been better...
Im sad they had that ph ban, luckily i stalked up
so 'teston-6' anyone even heard of it?
no i didn't think so.
i call bullsheit.
"100 mg red deer velvet antler"- theres your problem right there, I took this stuff once and gained like 20 lbs of muscle in 2 weeks, I new it had to be bad. I'm really supprised they didn't find large amounts ofin those supps.
they are in there 50's and 60's............
Being one was white and one was black is not convincing enough as black males are 60% more likely to have prostate cancer.
Testosterone has been proven to give older males more energy which will allow more availability to gain more muscle mass which the article contridicts this and is trying to say something else was in the product to cause the issue, which if this is the case a PH should not have been the cause and tells me this story is BS
"The most recent and reliable studies have shown that testosterone does not cause or produce deleterious effects on prostate cancer. In people who have undergone testosterone deprivation therapy, testosterone increases beyond the castrate level have been shown to increase the rate of spread of an existing prostate cancer."
Most likely they already had a pre-existing issue but people are so quick to blame a product for their issues. Some stuff just happens but as people become more money hungry, more and more people start sueing which pisses me off. More and more stories of stupidity / companies being sued are becoming a daily event from neglect in many cases, assume your responsibilities and do some research before doing ANYTHING. Some times it is ok but MANY times it is just someone being stupid and not taking responsibilities.
Consume at your own risk, if you are not sure on a product research it first! Think of how many people have used PH's and now think of how many have had such an issue from it..................
i think its sad that if the coroner did an autopsy of men aged 51-67 you would find that more than half of them had prostate cancer. to say it increased in almost a years time is something that could very well have happened naturally, but they didn't state that since it would be considered "a waste of funding for a stupid study".
call it my opinion, but that's the way i see it. as easy already pointed out, cancer grows much more rampantly when exposed to GH, and that's completely legal, and no federal guidelines on who is a candidate for GH therapy (so long as they can afford it).
For me, the message was/is the increasing lack of trust and confidence stemming directly from these type of stories. When I pop a supp these days, I wonder WTF is actually in it! SAD!
This mindset has been developed over time from the repeated stories coming from certain nefarious supp companies spiking OR falsifying ingredients of their products
One recent example for me: Axis Labs JUST DID this with Furazadrol YET they still Sponsor the board. I just dont get it. I'll digress out of respect for AM, but I have a right to be LIVID.
Why is there so much "forgiveness" ????
These type of companies are jacking with someone's health!!!
IMO: ONE STRIKE = death of the company should occur! Afterall, they are playing russian roullette with our health and being deceitful along the way! Screw that.
It's THIS sort of crap that enables the FDA to substantiate the stripping of our rights of banning supplements, in effort to protect OR AT LEAST use that as a facade in their argument to "protect us" from A-holes like the pricks that pull this crap.
They ruin it for everyone!
Nonetheless, the people involved were of such a group that their having prostate cancer isn't surprising. Plus I still can't get over the 10-11 months thing...it's obvious that no one knew what they were doing/talking about.
I guess us meat-head bodybuilder's are capable of more logic, reason, and common sense than suit and tie guys.
I do agree we need truth in labeling though...if it's in the bottle it needs to be on the label. Period.
I also think that if a product is mislabeled or bunk that it should be up to the consumer not to buy the product for those reasons. I don't need anyone from the government saying what is good for me or not and if I should buy it.
One more thing, two words: spell check.
Contains 6 Prohormones?
51yrs old & 67yrs old??
11 month cycle & 6 month cycle??
Chrysin, is BAD, horrible for your Thyroid. just an FYI.
The Scientist until no linked cancer with steroids not have enough evidence...
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