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Nitrogen retention in critically ill patients is proportional to the branched chain amino acid load

The nitrogen retention effect of branched chain enriched parenteral nutrition (BcAA) during surgical stress and polytrauma was evaluated in a prospective, randomized, double blind study in 32 patients. The doses of BcAA were 0.16, 0.3, 0.5, and 0.7 g/kg[middle dot]day with a total amino acid load of 1 or 1.3 g/kg[middle dot]day. It was provided in a setting of 30 glucose cal/kg[middle dot]day with 7 cal/kg[middle dot]day of iv fat also given to 16 patients. After the 7-day study was completed, analysis of the 4 treatment groups of 8 patients each demonstrated that there was an increased nitrogen retention effect of BcAA, that the effect was proportionate to BcAA load, that the effect started at 0.5 g of BcAA/kg[middle dot]day in a setting of balanced nutritional support, and that the effect was consistent with a BcAA influence on protein synthesis. There were no complications or side-effects from high dose BcAA. Metabolic support of the stress response in ICU patients has become a clinical reality.
 
eh honeslty i use almost 15g bcaa per day 4xday and its cheaper than what i usually do
 
I've been cutting bigtime with just extend, no whey protein at the moment. This is just something I'm trying,... all I'm saying is BCAA's have many benefits.
 
Future said:
Nitrogen retention in critically ill patients is proportional to the branched chain amino acid load

The nitrogen retention effect of branched chain enriched parenteral nutrition (BcAA) during surgical stress and polytrauma was evaluated in a prospective, randomized, double blind study in 32 patients. The doses of BcAA were 0.16, 0.3, 0.5, and 0.7 g/kg[middle dot]day with a total amino acid load of 1 or 1.3 g/kg[middle dot]day. It was provided in a setting of 30 glucose cal/kg[middle dot]day with 7 cal/kg[middle dot]day of iv fat also given to 16 patients. After the 7-day study was completed, analysis of the 4 treatment groups of 8 patients each demonstrated that there was an increased nitrogen retention effect of BcAA, that the effect was proportionate to BcAA load, that the effect started at 0.5 g of BcAA/kg[middle dot]day in a setting of balanced nutritional support, and that the effect was consistent with a BcAA influence on protein synthesis. There were no complications or side-effects from high dose BcAA. Metabolic support of the stress response in ICU patients has become a clinical reality.
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Good stuff brotha.
 
Future said:
Why would either really be relevant to the findings?
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Saturation point would be helpful as that would give a max dose, beyond which there is no further benefit. I.e. if 0.5g/kg is good, does that mean that the 1.3g/kg is almost 3x as good? Or is there a point of diminishing returns?

Publication date because I know Leucine by itself is becoming a hot topic and I just wondered where this fit in the timeline of BCAA goodness. :)
 
JN230 said:
eh honeslty i use almost 15g bcaa per day 4xday and its cheaper than what i usually do
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I've been toying around with the idea of taking 10 grams BCAA and 10 grams of liver tabs every three hours, for awhile now. Still, it'd cost over $100 a month, easy. Just being "frugal", I guess.
 
Resolve said:
Saturation point would be helpful as that would give a max dose, beyond which there is no further benefit. I.e. if 0.5g/kg is good, does that mean that the 1.3g/kg is almost 3x as good? Or is there a point of diminishing returns?

Publication date because I know Leucine by itself is becoming a hot topic and I just wondered where this fit in the timeline of BCAA goodness. :)
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I'd be really interseted in what you find out.
 
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