Supp companies are putting quercetin and bergamotten and bioperine in just about every other supplement that I come across. While these black pepper and grapefruit juice extracts and metabolites do increase the effect of the supps to which they are added, they do so in an arguably stupid and dangerous way. Just inhbit the CYP450 enzymes-duh.
Except that lots of drugs are metabolized by this pathway, including oral anabolics (if you take dbol with grapefruit juice, you better cut back the dose-elitefitness substantiates this) and drugs like diazepam/valium (which I take for muscle spasms) are so affected that you cannot take a supplement containing any of the above safely with diazepam and similar drugs. I found a study yesterday that showed that bergamotten increased plasma levels of diazepam in beagle by a factor of -100- when coadministered (10mg dose of diazepam given (I take 45mg a day), and the control group of diazepam only had levels of 2.5ng/dl or something and the coadministration group had levels of ~250ng/dl).
Granted, this would not kill most people, but you would be somewhat comatose for a day or two after just a single occurrence. One patient given 500mg of diazepam didn't have any serious effects except that he was in the hospital and in a light coma state for 3 days. DTHC, Animal Stak Flex, hell even a lot of COQ10 has Bioperine now, and lots of other supps that I would like to try just have to throw these ingredients in, and then I cannot take them. That is what irritates me; if people like it that way, that's fine. But why not have some versions of the above without these crude mechanism additives that are too dangerous for me to even take? More dangerous than real anabolics, no question, cuz I take those. And they don't even come with anything except a generic consult your physican label just like Centrum Silver or some similar crap! Thank the FDA and the DSHEA for not allowing more specific stuff like "medicines that interact with grapefruit juice will interact with this product, possibly dangerously so".
In my mind, the only purpose these chemicals serve is to make an inefficient product efficient (crudely) or to make an efficient product (like dbol) more efficient so that less is needed. At least dbol doesn't come with 5mg of bioperine per 5mg tablet!
Except that lots of drugs are metabolized by this pathway, including oral anabolics (if you take dbol with grapefruit juice, you better cut back the dose-elitefitness substantiates this) and drugs like diazepam/valium (which I take for muscle spasms) are so affected that you cannot take a supplement containing any of the above safely with diazepam and similar drugs. I found a study yesterday that showed that bergamotten increased plasma levels of diazepam in beagle by a factor of -100- when coadministered (10mg dose of diazepam given (I take 45mg a day), and the control group of diazepam only had levels of 2.5ng/dl or something and the coadministration group had levels of ~250ng/dl).
Granted, this would not kill most people, but you would be somewhat comatose for a day or two after just a single occurrence. One patient given 500mg of diazepam didn't have any serious effects except that he was in the hospital and in a light coma state for 3 days. DTHC, Animal Stak Flex, hell even a lot of COQ10 has Bioperine now, and lots of other supps that I would like to try just have to throw these ingredients in, and then I cannot take them. That is what irritates me; if people like it that way, that's fine. But why not have some versions of the above without these crude mechanism additives that are too dangerous for me to even take? More dangerous than real anabolics, no question, cuz I take those. And they don't even come with anything except a generic consult your physican label just like Centrum Silver or some similar crap! Thank the FDA and the DSHEA for not allowing more specific stuff like "medicines that interact with grapefruit juice will interact with this product, possibly dangerously so".
In my mind, the only purpose these chemicals serve is to make an inefficient product efficient (crudely) or to make an efficient product (like dbol) more efficient so that less is needed. At least dbol doesn't come with 5mg of bioperine per 5mg tablet!