Hey guys! Wondering if anyone give some info about PEA, I have tried searching anabolicminds but nothing, except about the taste of it. I just wanna know anything and everything you care to share about it. Thanks!
PEA = Phenylethylamine
It's a monoamine/neurotransmitter that is naturally found within our CNS (with stimulant effects), but our body has a hissy fit when we try to increase PEA levels within the brain/CNS - sure PEA passes the blood brain barrier fairly easily, but it is extensively metabolized upon ingestion via monoamine oxidases (specifically mao-A and mao-B). In plain terms, before PEA can exert effects in the CNS (which it is completely capable of doing) - it is quickly and efficiently converted into phenylacetic acid via oxidation (adding oxygen) before reaching the CNS to exert effects.
And another link PEA has being the skeleton to known, potent CNS stimulants is that it's chemical cousins are amphetamine and methamphetamine.
PEA = Phenylethylamine
Amphetamine = Alpha-Methyl-Phenylethylamine
Methamphetamine = Methyl-Amphetamine (Methylated Alpha-Methyl-Phenylethylamine)
As best put by Shulgin in his PIHKAL book (p. 816 for those with it) -
"Phenethylamine is intrinsically a stimulant, although it doesn't last long enough to express this property. In other words, it is rapidly and completely destroyed in the human body. It is only when a number of substituent groups are placed here or there on the molecule that this metabolic fate is avoided and pharmacological activity becomes apparent.
Qualitative comments:
With: 200, 400, 800, & 1600mg - "No effects"
With: 25 & 50mg i.v. - "No effects"
You're not gonna get any effects from PEA unless you have an MAOI drug co-administered, or decide to modify PEA perhaps by adding a methyl group to the first available position on the carbon chain (alpha), this methylated-PEA is - yep you guessed it - Amphetamine!! :smlove2:
PEA -
Amphetamine -
Methamphetamine -