Resveratrol not ready for prime time yet
- 11-10-2009, 03:34 PM
Resveratrol not ready for prime time yet
ScienceDaily (Dec. 19, 1997) — CHICAGO --- Researchers at Northwestern University Medical School have found that a chemical in red wine believed to help reduce risk for heart disease is a form of estrogen. The substance, resveratrol, is highly concentrated in the skin of grapes and is abundant in red wine.
Health & Medicine
Plants & Animals
Beer and Wine
Hormone replacement therapy
Moderate consumption of red wine has been widely reported to reduce risk for cardiovascular disease. Some researchers have attributed this cardioprotective quality to the significant amounts of resveratrol naturally present in grape skin.
Resveratrol protects grapes and some other plants against fungal infections. It has been shown previously to have a number of potentially beneficial properties, including antioxidant, anticoagulant, anti-inflammatory and anti-cancer effects.
Resveratrol has a molecular structure similar to that of diethylstilbestrol, a synthetic estrogen. This prompted Barry D. Gehm, J. Larry Jameson, M.D., and colleagues at Northwestern to investigate whether resveratrol might have pharmacologic properties similar to those of estradiol, the major natural human estrogen.
As reported in the Dec. 9 issue of the Proceedings of the National Academy of Sciences, the group's laboratory studies showed that resveratrol is estrogenic. (Specifically, it is a phytoestrogen, from the Greek word for "plant.") At concentrations similar to those required for its other biological effects, resveratrol activated expression of both artificially introduced "reporter" genes and naturally occurring estrogen-regulated genes in cultured human cells.
The researchers also found that resveratrol could replace estradiol in supporting the proliferation of certain breast cancer cells that require estrogen for growth.
"Estrogen" is not a specific compound but a category of substances defined by their biological effect. Originally named for their ability to induce estrus ("going into heat") in animals, estrogens act on cells by binding to a protein called estrogen receptor, which then causes certain genes to be expressed, or "turned on." In addition to the body's sex hormones, a number of other natural and artificial estrogens are known.
In studying gene expression, many laboratories use artificial reporter genes. The reporter gene used in these studies is the gene for the enzyme luciferase, which makes fireflies light up. It was connected to a piece of DNA that the estrogen receptor "recognizes." When this reporter gene was put into cells, luciferase production increased in those treated with estrogen. Then, when mixed with certain chemicals, the enzyme was measured easily by the light it gave off.
In some cells, resveratrol caused more expression of the reporter gene than estradiol. This was surprising, Gehm said, since estradiol has always been thought to produce maximal activation of the estrogen receptor. The group found that the most effective dose of resveratrol produced two to four times more light as the most effective dose of estradiol. However, estradiol is effective at much lower doses.
"The estrogenic properties of resveratrol may play a role in the beneficial cardiovascular effects of red wine and the so-called 'French paradox,'" Gehm said.
Estrogen is known to provide some protection against heart disease, and red wine also appears to. Their specific effects are similar, most notably, increasing high-density lipoprotein (HDL), the "good cholesterol." This effect of red wine may be mediated by resveratrol.
But Gehm cautioned that it is not yet known if the body absorbs enough resveratrol from wine to make this plausible. The same can be said of resveratrol's other effects, described earlier.
Some researchers have previously suggested that it would be beneficial to supplement people's diets with resveratrol because of its anticarcinogenic and anti-arteriosclerotic properties.
"The discovery that resveratrol is estrogenic means that such supplementation might have undesirable side effects," Gehm said.
Nevertheless, the observation that reseveratrol produces greater expression of some estrogen-regulated genes than estradiol may ultimately lead to the development of new, more selective estrogenic drugs. Selective estrogens currently available are used in the treatment of breast cancer (tamoxifen) and postmenopausal osteoporosis (raloxifene).
Barry D. Gehm is a research assistant professor of medicine; J. Larry Jameson, M.D., is the C. F. Kettering Professor of Medicine and chief of endocrinology at Northwestern University Medical School. Also collaborating on this study were Joanne M. McAndrews and Pei-Yu Chien
- 11-10-2009, 03:42 PM
11-11-2009, 11:43 AM
11-11-2009, 12:51 PM
I think the point still stands that there more we don't know about rez. The unknowns outnumber the knowns...like just about everything else on the supplement market.
11-11-2009, 12:55 PM
11-12-2009, 10:58 AM
11-12-2009, 11:18 AM
11-12-2009, 11:18 AM
Here's a decent one:
Resveratrol, a naturally occurring diphenolic compound, affects lipogenesis, lipolysis and the antilipolytic action of insulin in isolated rat adipocytes.
The Journal Of Steroid Biochemistry And Molecular Biology [J Steroid Biochem Mol Biol] 2009 Jan; Vol. 113 (1-2), pp. 17-24. Date of Electronic Publication: 2008 Nov 12.
Resveratrol is a naturally occurring diphenolic compound exerting numerous beneficial effects in the organism. The present study demonstrated its short-term, direct influence on lipogenesis, lipolysis and the antilipolytic action of insulin in freshly isolated rat adipocytes. In fat cells incubated for 90 min with 125 and 250 microM resveratrol (but not with 62.5 microM resveratrol), basal and insulin-induced lipogenesis from glucose was significantly reduced. The antilipogenic effect was accompanied by a significant diminution of CO(2) release and enhanced production of lactate. The inhibition of glucose conversion to lipids found in the presence of resveratrol was not attenuated by activator of protein kinase C. However, acetate conversion to lipids appeared to be insensitive to resveratrol. In adipocytes incubated for 90 min with epinephrine, 10 and 100 microM resveratrol significantly enhanced lipolysis, especially at lower concentrations of the hormone. However, the lipolytic response to dibutyryl-cAMP, a direct activator of protein kinase A, was unchanged. Further studies demonstrated that, in cells stimulated with epinephrine, 1, 10 and 100 microM resveratrol significantly enhanced glycerol release despite the presence of insulin or H-89, an inhibitor of protein kinase A. The influence of resveratrol on epinephrine-induced lipolysis and on the antilipolytic action of insulin was not abated by the blocking of estrogen receptor and was accompanied by a significant (with the exception of 1 microM resveratrol in experiment with insulin) increase in cAMP in adipocytes. It was also revealed that resveratrol did not change the proportion between glycerol and fatty acids released from adipocytes exposed to epinephrine. Results of the present study revealed that resveratrol reduced glucose conversion to lipids in adipocytes, probably due to disturbed mitochondrial metabolism of the sugar. Moreover, resveratrol increased epinephrine-induced lipolysis. This effect was found also in the presence of insulin and resulted from the synergistic action of resveratrol and epinephrine. The obtained results provided evidence that resveratrol affects lipogenesis and lipolysis in adipocytes contributing to reduced lipid accumulation in these cells.
M.Ed. Ex Phys
11-12-2009, 12:37 PM
So does anyone taking this product feel that they began reaching their fitness goals a little more quickly when they started?
11-12-2009, 12:48 PM
Res is being marketed for immediete benefits, and to say the least, that is about as false advertising as it gets. I see lots of wild claims made, but nothing backing them up.
I want to see some real third party blood tests showing that Res lowers E and raises T.
Anecdotally... I didn't get cancer today.
And where did this better sleep idea come from? Andecdotally people are suggesting shallower sleep and disturbances.
Honestly I think the industry wanted a holy grail and slapped it on Res since Red Wine has great benefits.
The Historic PES Legend
11-12-2009, 12:54 PM
11-12-2009, 12:58 PM
11-12-2009, 01:00 PM
11-12-2009, 01:04 PM
11-12-2009, 04:44 PM
11-12-2009, 04:49 PM
11-12-2009, 07:10 PM
Many people report immediate health benefits but not on the Richter scale, (on the anti-aging scale). Almost everyone feels better after SA.
Focusing on PP a bit, who are really one of the two big sellers of resveratrol products for sports. My main question is whether its a natural SERM, Gingko in some senses has SERM like behaviour but not quite what we think of as a SERM.
Certainly EndoAmp Max does exactly what it says on the can, I dunno how because it suggests there is a feedback loop between norephinephrine and dopamine, which is not possible (?), but dunno how else test can be boosted by crushing cortisol. Its as if they are linked. Anyway EndoAmp works, the more cortisol the stronger you feel it kick in and it feels like a dopamine boost. I could entirely wrong, but the data (even though sample size low) looks good, experience is good. PAS is a strong product.
11-12-2009, 11:32 PM
Well, not to bash rezveratrol yet(I am ordering it in my next supplement order), but th other active ingredient in Sustain Alpha is a test booster, so this raises the question of how much the resV is actually responsible for.
11-13-2009, 08:32 AM
Well as far as trans-resv goes, I have been taking stoked for 2 weeks now, and I feel a little dried out and I have sore joints, I have never had sore joints, so I am assuming my e levels are lower...it is not a placebo effect either, when I work out all my joints are sore, knees too. I warm up, proper diet, drink tons of water, all the good stuff. So I think i am getting a side effect from the trans-resv. Also have some acbe clearing up too if that means anything
11-13-2009, 08:35 AM
7,8 benzo is a fantastic compound and contributes 99.9% of the effects of sustain.
As for people having this immediate benfits of Res, how is this even acknowledged since the science does not support it? Critical thinking bring you to the point of a study. If you feel 100 people sugar pills and tell them they are sugar pills, they wont gain muscle. But tell those same 100 people that you are feeding them the strongest anabolic compound in the world, and only give them sugar pills again, and amazingly they gain 12 pounds in 3 weeks. The power of the mind is an amazing thing.
The Historic PES Legend
11-13-2009, 10:38 AM
11-15-2009, 11:49 PM
Fo-Ti (Chinese knotweed) has been the ancient part of Chinese medicine for hundreds of years at least. Its used for longevity. Resv. (Japanese knotweed extract) causes funky anti-aging responses in flies, worms that sort of thing. Anti-aging it looks good.
SERM / anti-estrogen effects are thought to occur. Yeah it needs real test boost effects to be sure. Alot of guys here are using resveratrol PCT - too many for it to be ineffective. IMO PP tend to get their science right. Whether their new product will out perform the most expensive preps of resveratrol out there is a big claim. Good if its true.
11-16-2009, 08:57 AM
The Historic PES Legend
11-16-2009, 09:12 AM
11-16-2009, 09:16 AM
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