Myostatin Inhibition - again!
10-31-2009 02:38 AM
Follistatin does more than just lower myostatin. I saw a study where they administered follistatin to mice that already had the myostatin gene knocked out so they weren't producing myostatin(so they were already big to begin with). After recieving the follistatin their muscles grew even larger; and since you can't block myostatin in a subject that can't produce it, it suggests that myostatin inhibition is only part of follistatin's muscle building equation.
Originally Posted by CDB
10-31-2009 06:26 PM
Myostatin gene knockout = double muscled mice.
Myostatin gene knockout + increased follistatin secretion = quadruple muscled mice!
11-01-2009 05:36 AM
"NO and cGMP induce expression of follistatin, and this secreted protein mediates their action in myogenesis."
Maybe NO supplements aren't as useless as most people(me) thought?
[take out the space, can't post links yet]
11-01-2009 04:06 PM
There are a lot of useful substances which have a positive effect on myostatin and follistatin levels. Even CLA suppresses myostatin.
11-02-2009 08:56 AM
And to be blunt, mice ain't humans and studies ain't the real world. Not to knock down your studies, I haven't read them yet, but there's every reason to be skeptical of this crap and no reason to think it would do anything to help build muscle.
Originally Posted by Vengeance187
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