GHenerate - The Reveal - Why the world needs a good GH sup
- 10-25-2009, 06:34 PM
GHenerate - The Reveal - Why the world needs a good GH sup
You guys asked for it, after logs reporting 8lbs, great sleep and good recovery...here it is
Why the world needs a GREAT GH supplement!
My parents are getting a little on in years and growth hormone replacement therapy is all the rage right now. I wanted to help get my parents a great GH product that worked. Sadly, I didn't see my mom injecting herself every day in order to look younger. I had read about GHRP-2 and GHRP-6 and I was intrigued. They show great promise in the literature! Unfortunately, these two peptide hormones are sold as injectables. I thought that maybe I could try them under the tongue to get penetration and to my pleasant surprise, there was some serious potential there. I was certainly not going to give her some homeopathic "GH" or deer velvet which I knew didn't work and quite frankly pissed me off.
I started looking heavily into growth hormone release and I saw that there are two main pathways. The first I've discussed, which is the GHRP pathway or the Growth Hormone Secretagogue receptor. This is stimulated by Ghrelin and GHRP-6/GHRP-2. This pathway is very potent at releasing GH and is a good route, yet there are more potent routes of growth hormone release which is why we needed a two phase technology to get the job done.
Unfortunately, GHRP-2 and GHRP-6 are illegal to sell in the US, since they are drugs and 100% synthetic. So, I started looking in the literature for NATURAL versions of GHRP to use. Luckily, I found a peptide in the fruit of Marus Alba that mimic's the effect of GHRP and it's natural analog Ghrelin (2). This was an amazing find, I could now legally sell a supplement that had the same effect as GHRP-2 without being illegal! Understand, that this peptide is not Ghrelin, but does exactly what synthetic peptides like GHRP-6 and GHRP-2 do, stimulate the GHSR receptor! Amazing find but I couldn't stop there.
GHRH is the other receptor that allows for LARGE increases in growth hormone (up to 12 times baseline). By stimulating this receptor you cause massive spikes in circulating GH. Luckily, we found an amazing GHRH stimulating supplement that I included in to boost growth hormone levels even higher. This pathway is totally new to the sports supplement world and the next paragraph will detail what GHRH agonist I found!
Puerariae Radix is a plant that has one particular constituent that is set to be the next superstar. It is called puerarin! Puerarin is an amazing nutrient that shows a 520% increase in growth hormone release (1) by stimulating the GHRH receptor. This ingredient was an amazing find but the key is the liquid "under the tongue" bioavailability which makes it biologically active. 520% increase in circulating GH is a HUGE increase and shows that this second pathway is very potent at releasing GH. We use only 98% pure puerarin complexed with cyclodextrin in our formula so it is ultra potent. Puerarin has also been shown to be an anti-aromatase, and a natural SERM, but this is not the main effect, compared to the GHRH stimulation, just a side benefit (3, 4). Finally, this wonder ingredient is a natural phosphoinositol 3 kinase (PI3K) stimulator which is the same anabolic pathway stimulated by and insulin to load the muscle with glycogen. I have to say, even I am impressed by this amazing material. GHRH stimulation, Aromatase Inhibition, natural SERM activity AND PI3K activity! Jackpot!
These two ultra potent pathways are what give GHenerate the amazing body recomp, appetite increasing effects that were experienced by our testers and make it the most potent GH secreting agent ever produced. One tester gained 8lbs on GHenerate alone, which is unheard of for a GH product. There is nothing on the market like GHenerate!
What about IGH-1? Luckily IGH-1, our GH secretagogue works in a totally different manner, which is to reduce somatostatin, meaning it will enhance and increase the potential of GHenerate. Somatostatin is the natural hormone your body produces to reduce GH production, so blocking this is a very good thing to do with GHenerate, so stacking the two is going to give exponential results.
While these studies are not conclusive, we just couldn't wait for years of clinical data on these ingredients to bring the product to market. We are looking into dong studies on all aspects of GH release with this product. We felt compelled to offer this product to people who like the science, wish to be early adopters to this new experience, see the value in the preliminary data and anecdotal experiences of our testers.
1) Horm Metab Res. 2004 Feb;36(2):86-91. Induction of growth hormone release by Pueraria thunbergiana BENTH. Jung DY, Ha H, Kim C. Drug Research and Development Team, Korea Institute of Oriental Medicine, 129-11 Chungdam-dong, Kangnam-ku, Seoul 135-100, Korea.
Puerariae Radix (PR), Puerariae Flos (PF), and Puerariae Surculus (PS) as well as their constituents were tested for induction of rat growth hormone (rGH) release by both rat pituitary cell culture and in vivo experimentation in order to develop them to novel drugs. Through a calibration curve of the rGH released by addition of rat growth hormone-releasing hormone (rGHRH) to rat pituitary cells, the 70 % ethanol extracts of PR and PS increased rGH release by about 1.6 and 1.7 times as high, respectively, as the control group (264.6 +/- 13.6 pM). However, each puerarin type as a representative constituent of PR in Korea Pharmacopeia (KP) and tectorigenin and an important ingredient of PF were twice as effective as in the control group. The acid hydrolysate of Puerariae Surculus (HPS) increased rGH release concentration-dependently, and its EC (50) was approximately 10.4 microg/ml. The T (max) value for rGH after injection of 20 microg/kg of rGHRH was 10 - 30 min, while the C (max) value was increased by approximately 12-fold compared to the control group (198.2 +/- 25.0 pM) and the AUC (0 - 45) was increased to 10 times the level of the control group (10,840.9 +/- 845.5 min. pM). On the other hand, T (max) for the HPS was 60 min, while C (max) was increased approximately to 5.8 fold compared to control (244.1 +/- 36.4 pM). C (max) for puerarin was 1,028.6 +/- 502.7 pM, that is, approximately 5.2 times as high as the control level. However, tectorigenin (20 microg/kg) was of no statistical significance. Therefore, we suggest that the HPS and puerarin act either on GH secretagogue receptors or on GHRH receptor of somatotrophin as possible agonists or an inhibitor on somatostatin receptor to release rGH, respectively.
2) Peptides. 2006 Jul;27(7):1597-602. Epub 2006 Feb 17. Ghrelin in plants: what is the function of an appetite hormone in plants? Aydin S Department of Biochemistry and Clinical Biochemistry, School of Medicine, Firat University, Firat Medical Center, 23119 Elazig, Turkey.
In the present work, we provide compelling evidence for the expression of a ghrelin-like peptide hormone that has only been associated with animals, in various plant tissues. Ghrelin, the appetite stimulating hormone, has been identified from a number of different species including humans, rat, pig, mouse, gerbil, eel, goldfish, bullfrog and chicken. The study here was conducted using an immunohistochemistry assay to screen whether plants have any ghrelin immunoreactivity. In this respect, Prunus x domestica L. and Marus alba were examined. Immunohistochemistry results showed that there is a strong human ghrelin immunoreactivity substance in the parenchyma cells of these plants. This was entirely unexpected since this hormone was considered to be present solely in animals. Thus, this study is the first to report the presence of a peptide with ghrelin-like activity in plants, a finding that has only been observed in the animal kingdom. RIA analysis confirmed that these plants contain significant amounts of this substance. Furthermore, -phase HPLC analyses of plant extracts showed an elution characteristic of the peptide identical to that of human ghrelin. In general, fruit from both plants had higher levels of the peptide than the vegetative parts.
3) Food Chem Toxicol. 2008 Dec;46(12):3671-6. Epub 2008 Sep 23. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Li Y, Chen H, Yang S, Xie G. Cancer Hospital of Tianjin, Tianjin Medical University, Ti-Yuan-Bei, Tianjin 330060, China. [email protected]
4) Toxicol Appl Pharmacol. 2008 Dec 15;233(3):371-81. Epub 2008 Sep 19. Mechanism of phytoestrogen puerarin-mediated cytoprotection following oxidative injury: estrogen receptor-dependent up-regulation of PI3K/Akt and HO-1. Hwang YP, Jeong HG.
- 10-25-2009, 08:30 PM
Ok that was a wealth of information, thanks for making that available, is the ai effect strong, and is ok to run this right after the use of an ai, or during pxt?
10-25-2009, 08:34 PM
10-25-2009, 09:01 PM
Interesting information. After reading some of the logs on here I was wanting to try it. When do you anticipate it hitting the market?
10-25-2009, 09:06 PM
10-25-2009, 10:07 PM
E-Pharm Rep... PM me with any questions or concerns
10-25-2009, 10:26 PM
10-25-2009, 11:05 PM
Body Performance Solutions
Home: http://bpsnutrition.net/Facebook: @Body Performance Solutions
10-26-2009, 12:38 AM
10-26-2009, 12:43 AM
10-26-2009, 01:49 AM
Nice, its awesome you found truly found two novel compounds to induce the GH release.
Do they in any way affect dopamine levels, and what are the recommended dosing times?
10-26-2009, 01:53 AM
How long should this be run before a break, or is this something that can be run indefinitely?
Is this something that can be run every day/night, or should it be 5 on, 2 off, or 3/1, etc.
10-26-2009, 05:00 AM
10-26-2009, 06:51 AM
10-26-2009, 08:13 AM
I personally think anyone wanting to take it longer than 60 days should take a week off then a 5 and 2 schedule indefinitely. Seems like with GHRP style peptides this is optimal dosing. Still, we know that most lifters don't do well with this protocol, so taking a week off in between cycles will suffice.
Also, it doesn't seem to effect dopamine levels at all (nothing I've read) so it shouldn't be an issue. Additionally, it stacks well with IGH-1.
We will be putting up a pre-order IGH-1 / GHenerate combo for $29.99 today!
10-26-2009, 08:16 AM
10-26-2009, 09:55 AM
10-26-2009, 11:10 AM
10-26-2009, 12:25 PM
10-26-2009, 01:51 PM
10-26-2009, 01:59 PM
10-26-2009, 02:08 PM
i saw 120 servings in a diffrent thread but it didnt say how many servings a day? want to know how much i need to buy to get a effective run at it.
10-26-2009, 02:16 PM
10-26-2009, 02:17 PM
the logs people were running were saying 4 sprays is a serving size and it seems like 2 times a day was what they were running.so assuming 4 sprays is a single serving that would be 60 days per bottle at 2 x's a day dosing.if so this is really a deal a 29.99 and i will be placing an order.
10-26-2009, 02:40 PM
I am looking for some different things to run while taking a year off anabolics.....hmmmmm ha
Head Purus Labs Rep
10-26-2009, 02:51 PM
I dont know if I should take the I-GH-1 with it or save it for a cycle of somthing. will it help alot if i take it with the HGenerate?
10-26-2009, 02:58 PM
10-26-2009, 03:35 PM
10-26-2009, 06:03 PM
The logs were using 6 sprays 2X per day...so that would be the serving size.
I would try the IGH-1 with it...
10-26-2009, 06:16 PM
Earlier someone suggested after 8 weeks of an AI is is ok to take ghenerate, if the AI is coupled with a test booster, are we ok to take the IGH-1 as well with the generate...the deal is so good i just want to buy some!!!
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