NSAIDs - bad for bodybuilding?

[hl80]

I heard that taking NSAIDs (ibuprofin, naproxin, etc.) were bad for muscle development. Anybody know if there's any truth to this?

 

[Chops89]

They can apparently inhibit protein synthesis to an extent.

 

[ecosocialist]

They can apparently inhibit protein synthesis to an extent.

Exactly. Talk to any of the arachidonic acid people, the more muscle inflammation you have, the more your body will bump up protein synthesis.

 

[rubberring]

Strangely enough, there was a study out not too long ago that had the opposite results. Granted, the subjects were older men, but protein synthesis obviously wasn't an issue.

http://www.sciencedaily.com/releases/2008/04/080406153404.htm

"Taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the amount of quadriceps muscle mass and muscle strength gained during three months of regular weight lifting, in a study by physiologists at the Human Performance Laboratory, Ball State University."

Either way, the negative effects on the liver in long-term use would cancel out any positive anabolic response.

 

[Chops89]

Strangely enough, there was a study out not too long ago that had the opposite results. Granted, the subjects were older men, but protein synthesis obviously wasn't an issue.

http://www.sciencedaily.com/releases/2008/04/080406153404.htm

"Taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the amount of quadriceps muscle mass and muscle strength gained during three months of regular weight lifting, in a study by physiologists at the Human Performance Laboratory, Ball State University."

Either way, the negative effects on the liver in long-term use would cancel out any positive anabolic response.

Interesting. Regardless, I would say popping a few Advil/Aleve/Aspirin, etc. here and there isn't really going to make any difference.

 

[AABigRick]

So now we have studies saying that it inhibts protein synthesis, and other other studies saying that it does not. The world will never know. lol. I never had a problem when I was on motrin for a month at 2400mg a day. Just remember everyone responds differently.