Rozman
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Would there be any advantages / disadvantages to taking 1-Carboxy and GABA together?
I personally do not like 1-Carboxy, since it is L-Dopa... only asking for parkisons.so u think it would be better to cycle between the two?
Only that you are playing with a **** ton of neuro transmitters.
Damn... I am at work or I would share the studies I have read. Yes it is a treatment to Parkinson, but the flood of dopamine of a normal healthy adult can destroy receptors in the brain, which can lead to neuro muscular disconnection.L-Dopa doesnt cause parkinsons...it is used in the treatment of PD patients b/c when injected directly into the Nucleus Accumbens it will restore motor activity.
The current theories on the causes of parkinsons are either toxins, genetics, or repeated head trauma leading in the death of dopaminergic cells in the pars compactia region of the Nucleus Accumbens. The only way for for the above supplements to cause Parkinson's is if the increase in L-Dopa caused by 1-carboxy leads to cell death. To my knowledge there is no evidence suggesting this is possible.
If anything research suggest this has neuro-protective qualities.
It's kinda like Adderall for ADD.Damn... I am at work or I would share the studies I have read. Yes it is a treatment to Parkinson, but the flood of dopamine of a normal healthy adult can destroy receptors in the brain, which can lead to neuro muscular disconnection.
Same with Ecstasy, but different hormone. The flood of serotonin causes damage to receptors which can lead to schizophrenia and depression... but funny thing is, X is being researched to treat... get this... schizophrenia and depression (Along with PTSD.)
Parkinsons is caused from a loss of dopaminergic neurons. Normally, these neurons function in the basal nuclei to give inhibitory signals to the thalamus and the brain stem neurons.Well when you get off of work i would love to read those studies.
While i was in school( oh three months ago) the most that i learned about flooding of L-Dopa may be a downregulation of the receptors, not cell death.
Think of it like this, drug chemistry doesnt destroy cells right off the bat..it downregulates the receptors which leads to tolerance. A flood of NT would only theoretically downregulate the receptors, not kill the cell. L-Dopa to my knowledge isnt membrane permeable so it couldnt destroy the cell.
The Dopamine isnt a hormone nor is L-Dopa, its a protein basaed messenger along with serotonin. Also Dopamine is used all over the brain so there is no reason why it would flood a specific area unless it was directly shot into that area.
Also shizophrenia i believe is also caused by defects within glutamte receptors, not dopamine.
Muscular disconnection...elaborate on that one
I wish i had more time to comment on this topic (maybe tomorrow night), but you're definitely on the right path here. There are plenty of studies out there that are concerning in this regard.Parkinsons is caused from a loss of dopaminergic neurons. Normally, these neurons function in the basal nuclei to give inhibitory signals to the thalamus and the brain stem neurons.
In parkinsons, with the loss of these neurons, the thalamus exhibits hyperexcitability on the cerebral cortex, and then on to the alpha motor neurons in the spinal cord. The brain stem neurons exhibit hyperexcitability onto alpha motor neurons in the spinal cord directly, which stimulate skeletal muscle contractions. Hyperexcitability of skeletal muscle contraction is why people with Parkinsons "shake".
So there is actually 2 pathways that Parkinsons is caused due to low dopamine. With the hyperexcitability, glutamate (excitatory), is overexpressed, which leads to neuronal death and causing the dementia symptoms seen in late Parkinson's.
Shizopherania is the OPPOSITE of all of this.
It is extremely stupid to use L-Dopa as a dietary supplement. When I was speaking to neurologist the other day I actually told her that L-Dopa was available as a dietary supplement and people used it for things like sleep. She looked at me like I was insane, and told me that it was a very bad idea to be taking it.
Even pharmaceutical Levodopa has a lot of known chronic side effects. Just google it. scholar.google.com
When you take Levodopa, your tolerance to it builds very quick. Taking L-Dopa now, just to sleep, since there is not much research done on how fast the tolerance resets, it could be never, is a bad idea.
Therefore if you were to get parkinsons down the road and they tried to put you on Levodopa, it would do jack for you.
There's a lot of more scientific reasons to not take it, but I think I've typed enough. Just don't take the L-Dopa.
Even GABA used as a supplement would be advised against by some. Loss of gabamanergic activity is what causes Huntington's.
You are right, Powerfull is not l-dopa, its a similar compound but not l-dopa which is SYNTHETIC.to bad powerfull is not L-Dopa but PureDOPA an extract of Mucuna Pruriens wich induces an increase in endogenous (natural) LevaDopa production that vastly outperforms synthetic LevaDopa
dose synthetic LevaDopa have more sides?
Parkinsons is caused from a loss of dopaminergic neurons. Normally, these neurons function in the basal nuclei to give inhibitory signals to the thalamus and the brain stem neurons.
Yep you are completely right, i stated that previously. You are wrong about where though. Parkinsons is caused by dopaminergic loss within the substantia nigra. Like trauma said it is these neurons that will project to the thalamus.
In parkinsons, with the loss of these neurons, the thalamus exhibits hyperexcitability on the cerebral cortex, and then on to the alpha motor neurons in the spinal cord. The brain stem neurons exhibit hyperexcitability onto alpha motor neurons in the spinal cord directly, which stimulate skeletal muscle contractions. Hyperexcitability of skeletal muscle contraction is why people with Parkinsons "shake".
So there is actually 2 pathways that Parkinsons is caused due to low dopamine. With the hyperexcitability, glutamate (excitatory), is overexpressed, which leads to neuronal death and causing the dementia symptoms seen in late Parkinson's.
Neither of these pathways have anything to do with increased NATURAL production of L-Dopa
Shizopherania is the OPPOSITE of all of this.
It is extremely stupid to use L-Dopa as a dietary supplement. When I was speaking to neurologist the other day I actually told her that L-Dopa was available as a dietary supplement and people used it for things like sleep. She looked at me like I was insane, and told me that it was a very bad idea to be taking it.
Not using L-Dopa, we are using a plant extract that increases your production of L-Dopa. We are not shooting up L-Dopa by any means
Even pharmaceutical Levodopa has a lot of known chronic side effects. Just google it. scholar.google.com
Again....not using that
When you take Levodopa, your tolerance to it builds very quick. Taking L-Dopa now, just to sleep, since there is not much research done on how fast the tolerance resets, it could be never, is a bad idea.
Therefore if you were to get parkinsons down the road and they tried to put you on Levodopa, it would do jack for you.
There's a lot of more scientific reasons to not take it, but I think I've typed enough. Just don't take the L-Dopa.
Even GABA used as a supplement would be advised against by some. Loss of gabamanergic activity is what causes Huntington's.
Please do not quote advertising. Mucuna contains L-DOPA.. there is no such thing as PureDOPA. PureDOPA is a name given by USP, just like thier other names in ReCreate (CellMend or whatever). 1-Carboxy is a 50% extract for L-Dopa I believe.to bad powerfull is not L-Dopa but PureDOPA an extract of Mucuna Pruriens wich induces an increase in endogenous (natural) LevaDopa production that vastly outperforms synthetic LevaDopa
dose synthetic LevaDopa have more sides?
Please tell me the difference between synthetic testosterone, and natural testosterone? This is an apples to apples comparison.
The major critique here is how bad L-Dopa is when supplemented in diet...we are doing this as i have stated previously. We are optimizing our natural output which like GABA research has suggested...is very good for you. If anyone has a study showing me how mucuna pruriens or 1-carboxy is bad for you then id love to see it. Ive already read studies abotu the inject of L-Dopa into the substantia nigra while i was taking out my B.S. in neuroscience. I cant argue with you there it would be stupid to take in dietary L-Dopa
To answer your question, cycling them.So getting back to my original question....
What would be better cycling them? Or taking them both?
I am starting to see a lot of research sayign GABA is amazing for you so taking it as a staple seems wise. 1-carboxy (powerfull) worked super well for me during a strength cycle.
Has anyone stacked both?
Yea i wasn't sure the details on huntington's. I just have "huntington's - gaba" in my notesI wish i had more time to comment on this topic (maybe tomorrow night), but you're definitely on the right path here. There are plenty of studies out there that are concerning in this regard.
The only thing i would add is that Huntington's Disease is actually a genetic-linked (hereditary) disease process that progressively causes degeneration of neurons. There is currently no effective treatment modality for it once it's been diagnosed.
Not trying to bash you, but you said that I was wrong about saying basal nuclei (same thing as basal ganglia).The major critique here is how bad L-Dopa is when supplemented in diet...we are doing this as i have stated previously. We are optimizing our natural output which like GABA research has suggested...is very good for you. If anyone has a study showing me how mucuna pruriens or 1-carboxy is bad for you then id love to see it. Ive already read studies abotu the inject of L-Dopa into the substantia nigra while i was taking out my B.S. in neuroscience. I cant argue with you there it would be stupid to take in dietary L-Dopa
hmmto bad powerfull is not L-Dopa but PureDOPA an extract of Mucuna Pruriens wich induces an increase in endogenous (natural) LevaDopa production that vastly outperforms synthetic LevaDopa
LOL, do not get scared, as long as you do not use for the rest of your life you are fine. Just use it on 4-6 week cycle till you run out. I would not recommend anyone to run anything continously EXCEPT adaptogens, PLCAR, and krill oil.... well, this is bad news for me. I bought a bunch of 100g tubs of USPowders 1-carboxy because of the supposed GH release benefits and sleep aid - I should have done more research because I definitely don't want Parkinsons
Who said they were lying? PureDOPA is just a name they made up for their ingredient. A lot of places do it, it's not illegal. But it is still L-Dopa.Another note, if USP is lying, what happens if someone decides to find out and test it. If this stands true, they can get sued. I do not think they will lie, since Mulletsoldier knows his law, there is a difference between puffery and not an INGREDIENT as labeled. This is why BSN got sued.
Why else would L-Dopa be a treatment for Parkinsons?Now if you increase total dopamine or L-Dopa in the brain...what makes you think it will concentrate itself to the substantia nigra?
There is not a single study done on showing that cycling it will allow your body to recover from tolerance, or showing any of this is true (that I could find at least). This is just brotelligence assumption commonly found on the boards. People think "well if its true for one thing it's true for all things". Tolerance is built up much faster than 10 years.Now if you take this stuff chronically for 10 years increased the dosage everytime you get tolerant...oh hell yeah PD is the least of your worries. But if you cycle this product responsibly the body shouldnt react negatively to it.
Right. There are studies on both delivery methods. My point is, there is proof that a strong tolerance is built up, and that the drug at first slows the progression of parkinson's, and then will no longer do anything for you.The studies i read is where they administered L-Dopa directed to the substantia nigra.
Also the side effects of L-Dopa supps is when administered in pill form, but this doesnt cause parkinsons seeing as the patient already had PD. If anything these studies showed that L-Dopa administration slowed down the progression of the disease.
I dont think i read any studies on the effects of L-Dopa on a healthy individual.
It would more decrease your chance of having successful/useful treatment from parkinsons than cause it. But I wouldnt be screwing with my dopamine levels on purpose if Parkinson's occured in my family...let alone building a tolerance to a drug that I could need to continue having a higher quality of life one day.I've been trying to look all over for a scholarly article that implies that L-Dopa will induce parkinsons disease, obviously my "search foo" still needs to be developed but if u can supply this research that would be greatly appreciated.
My grandfather had Parkinsons before he passed away so this is a very relevant topic for me. IF there are supps out there that will increase my risk my chances if getting the disease then i need not take them.
And especially since i have a great affinity to Powerfull from USP labs which contains 1-carboxy...well ur in essence telling me to take out one of my fave supps
How much are you really getting out of the product that you feel is worth the possible risk. Youre the only one who can answer that.And especially since i have a great affinity to Powerfull from USP labs which contains 1-carboxy...well ur in essence telling me to take out one of my fave supps
Honestly I cant answer that, but you and Natty both seem to be very bright and maybe you can do some reasearch that would benefit us all.This is the question im asking Bigmoe...is there a possible risk?
If this is all just theories based in fear and not fact then i wont stop it...now if there is any risk with the product then i wont take it.
I only take products i believe to be 100% safe...not 95% safe with a 5% chance of parkinsons.
Haha natty, i can see you are being very cautious not to step on toes. But in the end you are warning me that anything that if its converted/increases/mimics/etc L-Dopa should not be supplemented. This includes powerfull
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