Medical Clinic V.
University of Rome,
Curr. Med Res. Opin., (1981), 7, 475.Received: 13th March 1981
A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors
following stimulation by oral amino acids. the results showed that oral administration of a combination
of two amino acids (1200 mg l-lysine plus 1200 mg l-arginine) provoked a release of pituitary
somatotrophin and insulin. This phenomenon was reproducible and the growth hormone secreted in
response to this stimulation had biological activity (as demonstrated by radio recepter assay and
somatomedin induction). The effect appeared to be specific to the combination of the two amino
acids; neither of the amino acids demonstrated appreciable stimulating activity when administered
alone, even at the same doses.