Lcarnosine reduces telomere damage and shortening rate in cultured normal fibroblasts

[1HP]

Biochem Biophys Res Commun. 2004 Nov 12;324(2):931-6.
L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts.
Shao L, Li QH, Tan Z.
Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, PR China.
Telomere is the repetitive DNA sequence at the end of chromosomes, which shortens progressively with cell division and limits the replicative potential of normal human somatic cells. L-carnosine, a naturally occurring dipeptide, has been reported to delay the replicative senescence, and extend the lifespan of cultured human diploid fibroblasts. In this work, we studied the effect of carnosine on the telomeric DNA of cultured human fetal lung fibroblast cells. Cells continuously grown in 20 mM carnosine exhibited a slower telomere shortening rate and extended lifespan in population doublings. When kept in a long-term nonproliferating state, they accumulated much less damages in the telomeric DNA when cultured in the presence of carnosine. We suggest that the reduction in telomere shortening rate and damages in telomeric DNA made an important contribution to the life-extension effect of carnosine.
PMID: 15474517

 

[eatingisfun]

Cool, another benefit of beta alanine!

 

[John Smeton]

for us with limited reading skills at this time what does this mean?

 

[eatingisfun]

for us with limited reading skills at this time what does this mean?

Pretty much that if you were able to saturate your body with higher l-carnosine levels(20 milli mol in the study), you could reduce chromosome damage due to cell division and your DNA would remain "young" longer. Then you could possibly increase your lifespan. Ingesting beta alanine increases intra-cellular levels of l-carnosine.

 

[John Smeton]

Pretty much that if you were able to saturate your body with higher l-carnosine levels(20 milli mol in the study), you could reduce chromosome damage due to cell division and your DNA would remain "young" longer. Then you could possibly increase your lifespan. Ingesting beta alanine increases intra-cellular levels of l-carnosine.

Thanks. I already knew this. It is good to be reminded.

I took alcar for two years

and take beta alanine (P.s. Peak beta is the best bar none)

so thats why I look so young. nice!