search... there are many logs on AA... in the future please try to be more clear with ur questions...
search... there are many logs on AA... in the future please try to be more clear with ur questions...
I am a big supporter of AA products.
As for , it is being reformulated and shoud be re-released sometime soon.
If you have any questions about X Factor shoot me a PM. I'd be happy to help you out.
X Factor has some incredible reviews on this board and has shown some incredible recomp effects.
I don't like that AA is a major cause of cancer. Maybe a good trade?
Wherever that info. came from, was misinformed
CANCER YOU SAY?
Q. Will X Factor Cause Cancer
No the ingredient in x factor is not a carcinogen but like other non cancer causing growth promoting agents could be used by an existing tumor
In one study involving the prostate arachidonic acid was observed to cause growth through the PI3K mechanism (PI3K inhibitors blocked growth promoting effects) (18)
PI3K is also the mechanism by which works. So one of the ways acts as an anabolic is similar to .
Other studies have shown stimulation of protein synthesis by arachidonic acid through stimulation of the beta 2 receptor (19, 20) . But stimulation of beta 2 receptors doesn't cause cancer in non cancerous tissues.
Testosterone effects on cancer are analogous to the PI3K and beta 2 mechanisms I just mentioned. It doesn't cause cancer either, but cancer cells will make use of it as a growth promoting agent.
STUDIES ... YAY!
J Nutr. 2004 Dec;134(12 Suppl):3421S-3426S.
Dietary (n-6) PUFA and intestinal tumorigenesis. Whelan J, McEntee MF.
Cancer is the second leading cause of death in the United States, and mortality due to colorectal cancer is only surpassed by lung cancer. Epidemiological studies demonstrate that dietary polyunsaturated fats can have a profound effect on colorectal cancer risk. Experimental data indicate that modulation of cellular (n-6) PUFA metabolism can affect the progression of the disease. This paper discusses the role (n-6) PUFA play in promoting intestinal tumorigenesis and how dietary PUFA from different families interact to modify the neoplastic process. Dietary PUFA that attenuate arachidonic acid metabolism [such as (n-3) PUFA] have antineoplastic properties, whereas those that augment arachidonic acid metabolism, such as linoleic, gamma-linolenic, and arachidonic acids do not appear to enhance tumorigenesis when added to the Western diet but may diminish the beneficial effects of other dietary lipids. It is the relative contributions of the different dietary PUFA that may determine overall risk for and progression of the disease.Cancer. 1999 Sep 15;86(6):1019-27.
Association of energy and fat intake with prostate carcinoma risk: results from The Netherlands Cohort Study.
Schuurman AG, van den Brandt PA, Dorant E, Brants HA, Goldbohm RA.
Department of Epidemiology, Maastricht University, Maastricht, The Netherlands.
BACKGROUND: The roles of energy and fat intake as risk factors for prostate carcinoma are still questionable. Therefore, these factors were evaluated in the Netherlands Cohort Study described in this article. METHODS: The cohort study consisted of 58,279 men ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 642 incident prostate carcinoma cases were available for analysis. Intake of energy, fat, and separate fatty acids were measured by means of a self-administered questionnaire; fat intake was adjusted for energy by regression analysis. The case-cohort method was used to calculate rate ratios (RRs). Analyses were conducted for all prostate carcinoma cases together as well as for case subgroups (latent vs. nonlatent and localized vs. advanced). RESULTS: No associations were found in multivariate analyses between prostate carcinoma and intake of energy, total fat, total saturated fatty acids, or total trans unsaturated fatty acids (RR highest vs. lowest quintile: 0.99, 1.10, 1.19, and 0.99, respectively). Oleic acid intake showed a nonsignificant positive association (RR = 1.38, 95% CI: 0.88-2.19). Positive associations were also observed for intake of oleic acid in subgroup analyses. Linoleic (RR = 0.78, 95% CI: 0. 56-1.09) and linolenic (RR = 0.76, 95% CI: 0.66-1.04) acid intake were associated with nonsignificantly decreased risks; only for linolenic acid did these associations persist in subgroup analyses. No associations were found for intake of arachidonic acid, eicosapentaenoic acid, or docosahexaenoic acid. CONCLUSIONS: These data suggest that certain fatty acids might be involved in prostate carcinoma occurrence, although the possibility that these were chance findings cannot be ruled out. Copyright 1999 American Cancer Society.Bull Cancer. 2005 Jul;92(7):670-84. Related Articles, Links
[Dietary fatty acids and colorectal and prostate cancers: epidemiological studies]
Astorg P. UMR Inserm 557/INRA/CNAM Epidemiologie nutritionnelle, Institut scientifique et technique de l'Alimentation, Conservatoire national des Arts et Metiers, 5 rue du Vertbois, 75003 Paris. firstname.lastname@example.org
OBJECTIVE: This study reviews epidemiological works having studied the associations of dietary fatty acids, especially of n-6 or n-3 polyunsaturated fatty acids (PUFA), with the risks of colorectal and prostate cancers. METHODS: The epidemiological studies reviewed were those having tested the association of colorectal and prostate cancer risk with the dietary intake or the blood or adipose tissue levels of fatty acids, especially of n-6 and n-3 PUFA, and with the dietary intake of fish and seafood. RESULTS: Most studies based on a dietary questionnaire did not find any association of the risk of colorectal cancer with the consumption of either total fatty acids or any particular fatty acid, after adjustment for total energy intake had been made. A few studies suggest that trans fatty acid consumption could increase colorectal cancer risk. Most studies based either on a dietary questionnaire or on biomarkers, did not find any association of total, saturated or monounsaturated fatty acid, as well as of linoleic or arachidonic acids, with prostate cancer risk, after adjustment for total energy intake. Most studies failed to find an association of prostate cancer risk with fish or long-chain n-3 PUFA intake, but recent cohort studies did find an inverse association of fish consumption with the risk of the latest stages of prostate cancer. In contrast, alpha-linolenic acid intake was associated with an increase of prostate cancer risk in a majority of epidemiological studies, but other studies did not find this association. This latter point might be of concern, and needs to be clarified by other results, especially those of ongoing prospective studies.Am J Clin Nutr. 2004 Jul;80(1):204-16. Related Articles, Links
Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer.
Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC, Giovannucci EL.
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. email@example.com
BACKGROUND: Laboratory studies have shown that n-3 fatty acids inhibit and n-6 fatty acids stimulate prostate tumor growth, but whether the dietary intake of these fatty acids affects prostate cancer risk in humans remains unclear. OBJECTIVE: We prospectively evaluated the association between intakes of alpha-linolenic (ALA; 18:3n-3), eicosapentaenoic (EPA; 20:5n-3), docosahexaenoic (DHA; 22:6n-3), linoleic (LA; 18:2n-6), and arachidonic (AA; 20:4n-6) acids and prostate cancer risk. DESIGN: A cohort of 47866 US men aged 40-75 y with no cancer history in 1986 was followed for 14 y. RESULTS: During follow-up, 2965 new cases of total prostate cancer were ascertained, 448 of which were advanced prostate cancer. ALA intake was unrelated to the risk of total prostate cancer. In contrast, the multivariate relative risks (RRs) of advanced prostate cancer from comparisons of extreme quintiles of ALA from nonanimal sources and ALA from meat and dairy sources were 2.02 (95% CI: 1.35, 3.03) and 1.53 (0.88, 2.66), respectively. EPA and DHA intakes were related to lower prostate cancer risk. The multivariate RRs of total and advanced prostate cancer from comparisons of extreme quintiles of the combination of EPA and DHA were 0.89 (0.77, 1.04) and 0.74 (0.49, 1.08), respectively. LA and AA intakes were unrelated to the risk of prostate cancer. The multivariate RR of advanced prostate cancer from a comparison of extreme quintiles of the ratio of LA to ALA was 0.62 (0.45, 0.86). CONCLUSIONS: Increased dietary intakes of ALA may increase the risk of advanced prostate cancer. In contrast, EPA and DHA intakes may reduce the risk of total and advanced prostate cancer.
I'm not saying that X-Factor or any MN product leads to cancer in humans, but there exists a well established correlation between AA consumption and cancer in rodents. I was simply stating that was reason enough for me to avoid adding extra AA to my diet. I prefer the more mild eicosanoids like EPA, which tend to yeild less thromboxane. I apologize if my prior post came off as an accusation against your product. I've no doubt X-Factor is an effective anabolic.
Thanks for the support though.
Everyone has damaged cells but the body discards them easily. (P-53 I believe).
Ara at 1 gram for 50 days has been proven safe and effective. I can post a sleuth of more studies if you like, although I'm not sure you have read the studies I posted previously.
Much of the information you read on Ara through the media is based upon the average western diet which is high in fatty acids and sodium. Add to this the combination of unhealthy lifestyles - smoking, sedentary, alcohol, etc.... and you've got a combination for a lot of free radicals.
If you practice the above lifestyles please, by all means, do not waste your money on X Factor, in fact don't waste your money on any supplements. But if you have a good diet/training program and aren't a chain smoker and an alcoholic, then X Factor is a great supplement to be used.
AA is an inflammatory pathway- it's also naturally in some foods eaten..
I like the idea of increasing DOMS and what not to stimulate growth and the feedback has been decent, but inflammatory pathway stimulation if not done carefully can be detrimental to your health-- but in all honestly the same can be said for almost anything!
I understand completely what you're saying and the unknown is definitely a scary situation.
This is not meant against any in this thread, just a general statement, and I fall into this category, but many put otc hormones in their body that have very little data as to their health effects, long term or short term. Ara is not for everyone, but I think risk wise is not any higher than ph's and probably less. Its effectiveness is on par with or above almost any other otc product that claims to effect body composition, outside of hormones.
When does the bulk x factor come out?