matthias7
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Okay I’ve made a list of several nootropic agents below. The idea is to give the forum a general understanding of these compounds outside of stacks. Generally the stacks poorly represent the broad range of available supplements.
I have not cross checked this list for accuracy ( time is my master), so double check relevant information. Some of the information will be inaccurate, but gives a rough guide. Basically it is an almost complete (few things omitted) download of my memory.
I usually check my supplement intake for contra-indication with my physcian. Would advise everyone to do likewise. It is not definitive by any means but all supplements are legally obtained in the US market and I’ve since found in the UK market resulting from health stores importing the US product range (yippee!).
Sulbutiamine – synthetic B1. Medical use is to relieve chronic fatigue syndrome. A powerful supplement, which is really a drug. Presumably this will give loads of energy. Found in Core Zap and the other big stack the name of which escapes me. Maximum dose per day is 600mg. Do not exceed. Core Zap is just within the recommended limit.
Picamilon – synthetic B3 bound to GABA. Medical use unknown. Function, enables B3 to cross into the brain where is gives strong vasodilation. It is a powerful supplementDeveloped originally by the Russians.
Pyritinol – synthetic B6. Medical use unknown. Function unknown. Never tried it.
Phenibut – derivative of the inhibitory neurotransmitter GABA (if my memory serves me correctly). Powerful anti-anxiety drug. Develops rapid tolerance. Occasional use only. Withdrawal leads to anxiety and insomnia. Developed by the Russians, where I presume it is an underused alternative to vodka.
GABA - anti-anxiety. Hits the GABA pathway.
PEA – phenylethylamine. It is a precursor to both serotonin, GABA and dopamine pathway. Uses – don’t bother. Making it bio-available through the alimentary canal route is dangerous because it involves inactivating enzymes in the liver (MAO). Used in fat-burners, along with hordenine to inactive MAO. Another more long lasting MAO inhibitor is used in conjunction with hordenine in at least one commercially available fat burner. I would have thought this was a dangerous supplement because if you get the delivery correct it will stimulate all 3 dopamine, serotonin and GABA pathways, which I suspect could lead to severe withdrawl symptoms. Low bio-availability is the only thing blocking this.
Tyrosine – amino acid. It is very probably effective at targeting the dopamine pathway. Tyrosine -> L-dope -> dopamine.
ALCAR – amino acid. No evidence that it is a nootropic agent to my knowledge.
PAS – phosphatylserine an amino acid. It is widely considered to have nootropic effects. Primarily used to cap the cortisol response. A great all round supplement but an expensive one, so buy it from Primordial unless you find a bulk supplier but then the quality will be in doubt.
Theanine – directly crosses the blood membrane barrier and seems to promote relaxation. Without question a nootropic agent, precisely what it does I dunno.
Taurine – is probably a nootropic agent with cholinergic functions.
Choline and inositol. Widely available supplements which just don’t seem to do anything. I personally don’t think that choline will cross the blood-brain barrier because many neurotransmitters can’t do this once they are no longer precursors. I think using a choline precursor, i.e. alpha GPC is a better idea.
DMAE – a great cholinergic agent and its cheap
Centrophenoxine is DMAE with a plant alkaloid. Considered more powerful than the above. Is used to for medical condition involving some sort of confusion.
Alpha GPC. Besides nicotine this is the strongest cholinergic agent, at least in the short term. It is a precursor of choline – the vital molecular of neurotranmission.
Nicotine. Rapid tolerance, highly addictive, could be legally used as a transdermal patch in excess, e.g. for competition and will promote alertness. Very occasional use only primarily to check out the effectiveness of cholinergic agents. If nicotine doesn’t ‘hit the button’ the rest of the cholinergic stuff here will have no effect. An expensive and dangerous addiction for many, including mum.
Caffeine – illegal in excess for atheletes. Dangerous nootropic agent due rapid tolerance, addiction and reduction in deep sleep. Mostly ineffective because most of us have a fair degree of tolerance to it already. Causes a cortisol spike. This isn’t a good idea pre-work out, but post work out that’s good. Then again just taken a high GI carb, post work out.
Geranium (1,3-Dimethylpentylamine). A drug Merck developed but didn’t know what to do with and eventually became a supplement. I dunno what it does and can’t be bothered to find out. Added to several stacks including Core Zap and the other big stack the name of which escapes me.
Piracetam, – the classic nootropic agent. Considered harmless in excess. Harmless all round. Sweets probably have a greater nootropic effect than piracetam and are probably much more harmful causing tooth decay and in the long run diabetes. So with piracetam you can't lose! Given its status it is 'untouchable'. Really it is used in combination with say cholinergenic compounds where it can enhance their effect.
Interlectol (vinpocetine) – cheap supplement included in Focus XT. It could have numerous side effects. Never heard that it was “great”, so it might not be. It could cause liver damage – I am not sure.
Huperzine A - plant alkaloid readily available. It could have a long term benefit, I found no short term benefit.
Psycho-stimulants are not considered to be nootropic agents in this definition, e.g. Adderall. These are dangerous, resulting in rapid tolerance, addiction, could cause severe cardio-vascular problems and would be illegal to obtain. They are very readily abused. In any case there is no need to use them because if the above list isn’t enough then get urgent professional attention from a variety of sources. There is one “psycho-stimulant” that is supposed to be a legal supplement in the US I have never come across it as a supplement though. Pity it’s one of the two good ones.
I have not cross checked this list for accuracy ( time is my master), so double check relevant information. Some of the information will be inaccurate, but gives a rough guide. Basically it is an almost complete (few things omitted) download of my memory.
I usually check my supplement intake for contra-indication with my physcian. Would advise everyone to do likewise. It is not definitive by any means but all supplements are legally obtained in the US market and I’ve since found in the UK market resulting from health stores importing the US product range (yippee!).
Sulbutiamine – synthetic B1. Medical use is to relieve chronic fatigue syndrome. A powerful supplement, which is really a drug. Presumably this will give loads of energy. Found in Core Zap and the other big stack the name of which escapes me. Maximum dose per day is 600mg. Do not exceed. Core Zap is just within the recommended limit.
Picamilon – synthetic B3 bound to GABA. Medical use unknown. Function, enables B3 to cross into the brain where is gives strong vasodilation. It is a powerful supplementDeveloped originally by the Russians.
Pyritinol – synthetic B6. Medical use unknown. Function unknown. Never tried it.
Phenibut – derivative of the inhibitory neurotransmitter GABA (if my memory serves me correctly). Powerful anti-anxiety drug. Develops rapid tolerance. Occasional use only. Withdrawal leads to anxiety and insomnia. Developed by the Russians, where I presume it is an underused alternative to vodka.
GABA - anti-anxiety. Hits the GABA pathway.
PEA – phenylethylamine. It is a precursor to both serotonin, GABA and dopamine pathway. Uses – don’t bother. Making it bio-available through the alimentary canal route is dangerous because it involves inactivating enzymes in the liver (MAO). Used in fat-burners, along with hordenine to inactive MAO. Another more long lasting MAO inhibitor is used in conjunction with hordenine in at least one commercially available fat burner. I would have thought this was a dangerous supplement because if you get the delivery correct it will stimulate all 3 dopamine, serotonin and GABA pathways, which I suspect could lead to severe withdrawl symptoms. Low bio-availability is the only thing blocking this.
Tyrosine – amino acid. It is very probably effective at targeting the dopamine pathway. Tyrosine -> L-dope -> dopamine.
ALCAR – amino acid. No evidence that it is a nootropic agent to my knowledge.
PAS – phosphatylserine an amino acid. It is widely considered to have nootropic effects. Primarily used to cap the cortisol response. A great all round supplement but an expensive one, so buy it from Primordial unless you find a bulk supplier but then the quality will be in doubt.
Theanine – directly crosses the blood membrane barrier and seems to promote relaxation. Without question a nootropic agent, precisely what it does I dunno.
Taurine – is probably a nootropic agent with cholinergic functions.
Choline and inositol. Widely available supplements which just don’t seem to do anything. I personally don’t think that choline will cross the blood-brain barrier because many neurotransmitters can’t do this once they are no longer precursors. I think using a choline precursor, i.e. alpha GPC is a better idea.
DMAE – a great cholinergic agent and its cheap
Centrophenoxine is DMAE with a plant alkaloid. Considered more powerful than the above. Is used to for medical condition involving some sort of confusion.
Alpha GPC. Besides nicotine this is the strongest cholinergic agent, at least in the short term. It is a precursor of choline – the vital molecular of neurotranmission.
Nicotine. Rapid tolerance, highly addictive, could be legally used as a transdermal patch in excess, e.g. for competition and will promote alertness. Very occasional use only primarily to check out the effectiveness of cholinergic agents. If nicotine doesn’t ‘hit the button’ the rest of the cholinergic stuff here will have no effect. An expensive and dangerous addiction for many, including mum.
Caffeine – illegal in excess for atheletes. Dangerous nootropic agent due rapid tolerance, addiction and reduction in deep sleep. Mostly ineffective because most of us have a fair degree of tolerance to it already. Causes a cortisol spike. This isn’t a good idea pre-work out, but post work out that’s good. Then again just taken a high GI carb, post work out.
Geranium (1,3-Dimethylpentylamine). A drug Merck developed but didn’t know what to do with and eventually became a supplement. I dunno what it does and can’t be bothered to find out. Added to several stacks including Core Zap and the other big stack the name of which escapes me.
Piracetam, – the classic nootropic agent. Considered harmless in excess. Harmless all round. Sweets probably have a greater nootropic effect than piracetam and are probably much more harmful causing tooth decay and in the long run diabetes. So with piracetam you can't lose! Given its status it is 'untouchable'. Really it is used in combination with say cholinergenic compounds where it can enhance their effect.
Interlectol (vinpocetine) – cheap supplement included in Focus XT. It could have numerous side effects. Never heard that it was “great”, so it might not be. It could cause liver damage – I am not sure.
Huperzine A - plant alkaloid readily available. It could have a long term benefit, I found no short term benefit.
Psycho-stimulants are not considered to be nootropic agents in this definition, e.g. Adderall. These are dangerous, resulting in rapid tolerance, addiction, could cause severe cardio-vascular problems and would be illegal to obtain. They are very readily abused. In any case there is no need to use them because if the above list isn’t enough then get urgent professional attention from a variety of sources. There is one “psycho-stimulant” that is supposed to be a legal supplement in the US I have never come across it as a supplement though. Pity it’s one of the two good ones.
