This is a relatively new compound in our ever-changing world of supplements (old to the rest of the world), but it seems to hold alot of promise. So far, the only mainstream product that I know of that has evodiamine as one of its active ingredients is VPX'sand their product. As more research is conducted on it, I'm sure there will be more studies. I tried a one serving sample of Redline (available to anyone on the vpx web-site) and I definitely noticed a significant boost in energy and an increase in skin temperature. I will probably definitely pick a bottle of this stuff up when cutting season comes around.
Enough of my babbling, time for a little bit of information on the promising compound evodiamine.
General Description From Breastman @ Anabolic Review
This novel compound is a major alkaloidal principal of Evodia fruits (Evodia rutaecarpa, Rutaceae) that is often referred to in Chinese literature as a “hot nature”herb. Evodiamine shows the amazing ability to burn fat through a mechanism by which the skin of mammals can be thermogenically heated by up to five degrees with no change in core body temperature. If taken in the absence of food, however, evodiamine also has the potential to significantly increase core temperature. Because evodiamine is a vanilloid receptor agonist, this incredible substance has the unique ability to increase heat production and heat loss simultaneously, and dissipate food energy (FAT) as heat.
So it looks nice in a product description, but all of you science minded folks want research to back it up. However, there have been no studies yet focusing in on the effects of evodiamine and body composition. But I come with some preliminary research for us to draw our own conclusions on. Hopefully, some people on the board have used Redline or something else with evodiamine, and can comment on their results here.
Pharmacol Biochem Behav. 1995 Feb;50(2):293-8.
Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats.
Tsai TH, Lee TF, Chen CF, Wang LC.
Department and Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan.
Dehydroevodiamine (DeHE) and evodiamine (EVO), alkaloids isolated from a Chinese medicinal herb, Wu-chu-yu, exhibit calcium antagonistic activity. Intraperitoneal injections of DeHE (5-20 mg/kg) and EVO (2.5-10 mg/kg) caused a dose-related hypothermia in afebrile rats at an ambient temperature (Ta) of 20 degrees C. Because the heat production of alkaloid-injected rats did not differ from that of the controls, the hypothermic effect likely resulted from increased peripheral heat loss. This suggestion is supported by the finding that both DeHE and EVO did not affect the thermoregulatory response of rats exposed to a Ta of 35 degrees C, at which heat loss was maximized. Injection of the same doses of DeHE and EVO attenuated the febrile response in a dose-related manner, induced by intrahypothalamic injection of exogenous pyrogen. The attenuation of the febrile response was associated with a reduction in heat production. Because DeHE and EVO did not affect HP in afebrile rats at a Ta of either 20 or 35 degrees C, but suppressed the metabolic rate of febrile rats at 20 degrees C, the thermoregulatory effect of DeHE and EVO could involve both a calcium-dependent increase in heat loss and a suppression in heat production; the latter may only be manifested when the set point for thermoregulation is elevated.
More Thermoregulation..(less of an effect exhibited)
Chem Pharm Bull (Tokyo). 1991 Mar;39(3):690-2. Related Articles, Links
Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the Chinese traditional medicine, "goshuyu-to" and component crude drugs.
Kano Y, Zong QN, Komatsu K.
Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.
We orally administered Goshuyu-to or Evodia fruit extract and Ginger extract to untreated rats, and found a slight but not significant rise in their body temperature. In rats treated with chlorpromazine, the administration of Goshuyu-to prevented decrease in the body temperature. After administration of each extract of component crude drugs (Evodia fruit, Ginger, Ginseng: Jujube: such an effect was recognized only by Evodia fruit, and other component crude drugs exhibited no body temperature retaining effect in this experiment system. We further studied the effect of Evodia fruit alkaloid hydroxyevodiamine, evodiamine, rutaecarpine and evocarpine used individually and confirmed that the body temperature retaining effect occurred mainly with evodiamine.
Antianoxic Effects (hemoglobin becomes more oxygenated, which might theoretically lead to increased atheletic performance and faster recovery from training)
J Ethnopharmacol. 1989;27(1-2):185-92. Related Articles, Links
Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit.
Yamahara J, Yamada T, Kitani T, Naitoh Y, Fujimura H.
Kyoto Pharmaceutical University, Japan.
In order to determine the antianoxic potential of evodiamine, its effects were compared to those of vinpocetine (VPT), using a series of animal models of anoxia. In mice, evodiamine was equivalent to VPT in the KCN-induced anoxia model but was greater than VPT in the low-pressure-induced anoxia model. Its effectiveness was increased by combined treatment with physostigmine, suggesting the involvement of a cholinergic mechanism in the antianoxic action of evodiamine.
Please post any more PERTINENT studies you may find, both positive and negative.