Evodiamine: Miracle Fat Burner or Over-Hyped Junk?

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    Evodiamine: Miracle Fat Burner or Over-Hyped Junk?


    This is a relatively new compound in our ever-changing world of supplements (old to the rest of the world), but it seems to hold alot of promise. So far, the only mainstream product that I know of that has evodiamine as one of its active ingredients is VPX's Meltdown and their Redline product. As more research is conducted on it, I'm sure there will be more studies. I tried a one serving sample of Redline (available to anyone on the vpx web-site) and I definitely noticed a significant boost in energy and an increase in skin temperature. I will probably definitely pick a bottle of this stuff up when cutting season comes around.

    Enough of my babbling, time for a little bit of information on the promising compound evodiamine.



    General Description From Breastman @ Anabolic Review

    Evodiamine

    This novel compound is a major alkaloidal principal of Evodia fruits (Evodia rutaecarpa, Rutaceae) that is often referred to in Chinese literature as a “hot nature”herb. Evodiamine shows the amazing ability to burn fat through a mechanism by which the skin of mammals can be thermogenically heated by up to five degrees with no change in core body temperature. If taken in the absence of food, however, evodiamine also has the potential to significantly increase core temperature. Because evodiamine is a vanilloid receptor agonist, this incredible substance has the unique ability to increase heat production and heat loss simultaneously, and dissipate food energy (FAT) as heat.

    So it looks nice in a product description, but all of you science minded folks want research to back it up. However, there have been no studies yet focusing in on the effects of evodiamine and body composition. But I come with some preliminary research for us to draw our own conclusions on. Hopefully, some people on the board have used Redline or something else with evodiamine, and can comment on their results here.


    Thermoregulation
    Pharmacol Biochem Behav. 1995 Feb;50(2):293-8.


    Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats.

    Tsai TH, Lee TF, Chen CF, Wang LC.

    Department and Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan.

    Dehydroevodiamine (DeHE) and evodiamine (EVO), alkaloids isolated from a Chinese medicinal herb, Wu-chu-yu, exhibit calcium antagonistic activity. Intraperitoneal injections of DeHE (5-20 mg/kg) and EVO (2.5-10 mg/kg) caused a dose-related hypothermia in afebrile rats at an ambient temperature (Ta) of 20 degrees C. Because the heat production of alkaloid-injected rats did not differ from that of the controls, the hypothermic effect likely resulted from increased peripheral heat loss. This suggestion is supported by the finding that both DeHE and EVO did not affect the thermoregulatory response of rats exposed to a Ta of 35 degrees C, at which heat loss was maximized. Injection of the same doses of DeHE and EVO attenuated the febrile response in a dose-related manner, induced by intrahypothalamic injection of exogenous pyrogen. The attenuation of the febrile response was associated with a reduction in heat production. Because DeHE and EVO did not affect HP in afebrile rats at a Ta of either 20 or 35 degrees C, but suppressed the metabolic rate of febrile rats at 20 degrees C, the thermoregulatory effect of DeHE and EVO could involve both a calcium-dependent increase in heat loss and a suppression in heat production; the latter may only be manifested when the set point for thermoregulation is elevated.

    More Thermoregulation..(less of an effect exhibited)
    Chem Pharm Bull (Tokyo). 1991 Mar;39(3):690-2. Related Articles, Links


    Pharmacological properties of galenical preparation. XIV. Body temperature retaining effect of the Chinese traditional medicine, "goshuyu-to" and component crude drugs.

    Kano Y, Zong QN, Komatsu K.

    Hokkaido Institute of Pharmaceutical Sciences, Otaru, Japan.

    We orally administered Goshuyu-to or Evodia fruit extract and Ginger extract to untreated rats, and found a slight but not significant rise in their body temperature. In rats treated with chlorpromazine, the administration of Goshuyu-to prevented decrease in the body temperature. After administration of each extract of component crude drugs (Evodia fruit, Ginger, Ginseng: Jujube: such an effect was recognized only by Evodia fruit, and other component crude drugs exhibited no body temperature retaining effect in this experiment system. We further studied the effect of Evodia fruit alkaloid hydroxyevodiamine, evodiamine, rutaecarpine and evocarpine used individually and confirmed that the body temperature retaining effect occurred mainly with evodiamine.

    Antianoxic Effects (hemoglobin becomes more oxygenated, which might theoretically lead to increased atheletic performance and faster recovery from training)
    J Ethnopharmacol. 1989 Nov;27(1-2):185-92. Related Articles, Links


    Antianoxic action of evodiamine, an alkaloid in Evodia rutaecarpa fruit.

    Yamahara J, Yamada T, Kitani T, Naitoh Y, Fujimura H.

    Kyoto Pharmaceutical University, Japan.

    In order to determine the antianoxic potential of evodiamine, its effects were compared to those of vinpocetine (VPT), using a series of animal models of anoxia. In mice, evodiamine was equivalent to VPT in the KCN-induced anoxia model but was greater than VPT in the low-pressure-induced anoxia model. Its effectiveness was increased by combined treatment with physostigmine, suggesting the involvement of a cholinergic mechanism in the antianoxic action of evodiamine.


    Please post any more PERTINENT studies you may find, both positive and negative.

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    Reduced Test secretion?:

    Metabolism. 1999 Dec;48(12):1532-5. Related Articles, Links


    Effects of evodiamine on the secretion of testosterone in rat testicular interstitial cells.

    Lin H, Tsai SC, Chen JJ, Chiao YC, Wang SW, Wang GJ, Chen CF, Wang PS.

    Department of Physiology, School of Life Science, and School of Medicine, National Yang-Ming University, Taipei, Taiwan, Republic of China.

    Evodiamine, a bioactive component isolated from the Chinese medicine Wu-chu-yu, exhibits vasodilative and antianoxic action. Although evodiamine indeed has many biological effects, its effects on the endocrine system are not clear. The present study explored the effects of evodiamine on testosterone secretion in vitro. Rat collagenase-dispersed testicular interstitial cells (TICs) were incubated with evodiamine (0 to 10(-4) mol/L) in the presence or absence of human chorionic gonadotropin (hCG), forskolin, 8-bromo-adenosine 3':5'-cyclic monophosphate (8-Br-cAMP), or steroidogenic precursors (including 25-hydroxycholesterol, pregnenolone, progesterone, 17alpha-hydroxyprogesterone, and androstenedione) at 34 degrees C for 1 hour. The testosterone concentration in the media samples was measured by radioimmunoassay. Evodiamine 10(-4) mol/L was effective to reduce both basal and hCG-stimulated testosterone secretion in rat TICs after 1, 2, or 4 hours of incubation. The stimulatory effect of forskolin on testosterone release in TICs was prevented by administration of evodiamine. Evodiamine 10(-4) mol/L also decreased 8-Br-cAMP- and androstenedione-stimulated testosterone secretion. These results suggest that evodiamine reduces testosterone secretion in rat TICs via a mechanism involving reduced activity of cAMP-related pathways and 17beta-hydroxysteroid dehydrogenase (17beta-HSD).

    evodiamine thread on bb.com
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    Cayenne has a similar effect on thermogenesis.
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    Effect of evodiamine on catecholamine secretion from bovine adrenal medulla.

    Yoshizumi M, Houchi H, Ishimura Y, Hirose M, Kitagawa T, Tsuchiya K, Minakuchi K, Tamaki T.

    Department of Pharmacology, University of Tokushima School of Medicine, Japan.

    The effect of evodiamine on catecholamine secretion from bovine adrenal medulla was investigated. Evodiamine, a bioactive component isolated from dry unripened fruit of Evodia rutaecarpa Bentham, was found to stimulate the secretion of catecholamine from perfused bovine adrenal medulla at a concentration of 10 microM and its effect persisted for at least 30 min. This stimulatory effect of evodiamine was abolished by omission of Ca2+ from the perfusion fluid. Evodiamine (0.1-10 microM) markedly enhanced the secretion of catecholamine from the adrenal medulla induced by acetylcholine (100 microM or high K+(56 mM). The secretion of catecholamine was promptly enhanced by acetylcholine or high K+, but returned to the control level on treatment for 20 min. However, when evodiamine was added to the perfusion fluid after acetylcholine or high K+ stimulation for 10 min, the secretion of catecholamine again increased greatly. These results indicate that evodiamine not only stimulated the secretion of catecholamine from bovine adrenal medulla but also reversed insensitivity of these cells to acetylcholine or high K+ stimulation.


    Comparative study of the vasodilatory effects of three quinazoline alkaloids isolated from Evodia rutaecarpa.

    Chiou WF, Liao JF, Chen CF.

    National Research Instituter of Chinese Medicine, Tapei Hsein, Taiwan.

    The vasoreactivity of dehydroevodiamine (1), evodiamine (2), and rutaecarpine (3), quinazoline alkaloids isolated from Evodia rutaecarpa, to aorta smooth muscle demonstrated that they produce a vasodilatory effect on endothelium-intact rat aorta with equal potency. Compound 3 produced a full (100%) nitric oxide-dependent vasodilatation, whereas 2 and 1 produced a partially endothelium-dependent effect, 50% and 10%, respectively. At the same time, I and 2 may also act by other mechanisms, including probably an alpha1-adrenoceptor blocking action and a 5-HT antagonizing action, respectively.


    Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats.

    Tsai TH, Lee TF, Chen CF, Wang LC.

    Department and Institute of Pharmacology, National Yang-Ming Medical College, Taipei, Taiwan.

    Dehydroevodiamine (DeHE) and evodiamine (EVO), alkaloids isolated from a Chinese medicinal herb, Wu-chu-yu, exhibit calcium antagonistic activity. Intraperitoneal injections of DeHE (5-20 mg/kg) and EVO (2.5-10 mg/kg) caused a dose-related hypothermia in afebrile rats at an ambient temperature (Ta) of 20 degrees C. Because the heat production of alkaloid-injected rats did not differ from that of the controls, the hypothermic effect likely resulted from increased peripheral heat loss. This suggestion is supported by the finding that both DeHE and EVO did not affect the thermoregulatory response of rats exposed to a Ta of 35 degrees C, at which heat loss was maximized. Injection of the same doses of DeHE and EVO attenuated the febrile response in a dose-related manner, induced by intrahypothalamic injection of exogenous pyrogen. The attenuation of the febrile response was associated with a reduction in heat production. Because DeHE and EVO did not affect HP in afebrile rats at a Ta of either 20 or 35 degrees C, but suppressed the metabolic rate of febrile rats at 20 degrees C, the thermoregulatory effect of DeHE and EVO could involve both a calcium-dependent increase in heat loss and a suppression in heat production; the latter may only be manifested when the set point for thermoregulation is elevated.
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    Alright YeahRight - what was the point of bumping this one?


    (Or whatever mod - I sure as hell don't make it a point to bump old-azz threads like this. )



    The studies in this thread suck - all are on freaking rats. Ugh.

    Carry on.
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