All the write ups I've read say that TTA is a PPAR Antagonist, that doesn't make since at all, especially when it says PPAR Alpha (the co-factor PGC-1Alpha i assume?), that transcription factor is a gene promoter for mitochondria function, it doesn't make since to antagonize the PPAR receptor and increase metabolism. Hopefully the write up was wrong and they meant agonist, or maybe i totally don't understand that pathway, but in the research we do at school, we have been looking at PGC1Alpha and it's effects on mitochondria function, so I do know a thing or two about this stuff .
i checked pubmed.. i found a handful of articles stating its a PPAR agonist not antagonist >< that scares me.. who wrote that writeup and how could you knowing write the other stuff without knowing what a agonist/antagonist is? typo i hope.