USPLabs PRIME -what is the final verdict with regards to supression?

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  1. Question USPLabs PRIME -what is the final verdict with regards to supression?


    Ok, the product has been out for a while now. Some people say it helps them build muscle some say not so much. That aspect has been discussed a great deal and I am not intending to restart that debate.

    My question is what the final verdict has been with regards to suppression. Does it lead to a decline in natural testosterone production if used alone?

    Thanks


  2. Never was an issue of suppression. The LH & T levels were unchanged from what I understand of the bloodwork done on the initial testers.
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  3. Are you serious?

  4. Quote Originally Posted by Steveoph View Post
    Never was an issue of suppression. The LH & T levels were unchanged from what I understand of the bloodwork done on the initial testers.
    Agreed.
    Zero suppression, zero PCT needed. You are all set.

    :bb3:
    \\ USPlabs Alpha Ginger //

  5. Quote Originally Posted by Sub7 View Post
    Ok, the product has been out for a while now. Some people say it helps them build muscle some say not so much. That aspect has been discussed a great deal and I am not intending to restart that debate.

    My question is what the final verdict has been with regards to suppression. Does it lead to a decline in natural testosterone production if used alone?

    Thanks
    it's not a hormonal product. ur final debate could have been answered before the product was even used by anybody
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  6. Quote Originally Posted by jsp0785 View Post
    it's not a hormonal product. ur final debate could have been answered before the product was even used by anybody
    So PRIME will activate the androgen receptors in muscle tissue, but the receptors in the hypothalamus will not recognize this molecule at all? This is quite revolutionary if true. Do any independent testers have blood results?

    Thanks

  7. Quote Originally Posted by Sub7 View Post
    So PRIME will activate the androgen receptors in muscle tissue, but the receptors in the hypothalamus will not recognize this molecule at all? This is quite revolutionary if true. Do any independent testers have blood results?

    Thanks
    This is why I have a very hard time beliving the bs about phytoandrogens or whatever.
  8. Guest
    Guest's Avatar

    Quote Originally Posted by Sub7 View Post
    So PRIME will activate the androgen receptors in muscle tissue, but the receptors in the hypothalamus will not recognize this molecule at all? This is quite revolutionary if true. Do any independent testers have blood results?

    Thanks

    It does not activate the androgen receptor...

  9. then hows it work....

  10. Quote Originally Posted by digitalducki View Post
    then hows it work....
    That's what theyre trying to figure out with a Penn state study

  11. Quote Originally Posted by USPLabs View Post
    It does not activate the androgen receptor...
    2 questions:

    1- Some anabolics that do not bind to androgen receptors still cause HTPA shutdown. It is puzzling to me how this happens; I even started a thread in mindandmuscle long time ago to ask specifically this question but got no explanation. My understanding is that nobody really knows how an anabolic drug that causes muscle growth without AR agonism causes shutdown. So do we know for sure that PRIME does not cause shutdown? Any blood tests?

    2- How did we determine that PRIME does not activate AR?


    I am asking those questions not because I dislike PRIME. To the contrary, I love it. I ordered 3 bottles from the initial sale and used 1 full bottle. The pumps were awesome and unlike any other substance I ever took. I was taking 9 pills a day and also put on some muscle. Unfortunately, I got injured right at the end of bottle 1, but I am good now. I will soon do a cycle with the two remaining bottles. However, I just want to make sure that PRIME does not cause shutdown before I proceed...
    Thanks

    Sub

  12. I can only give my experience without bloodwork. I've tried tren xtreme and epistane before and prime is not at all the same in regards to shutdown. Yes I did get shutdown a little bit with epistane and more with tren xtreme and had SERMs on hand for that. Doing 2nd run of prime right now and no shutdown at all. Had no problems keeping about 80% of the strength gained from prime. I wouldn't say it was as easy with the DS/PH at all.

  13. Quote Originally Posted by eatingisfun View Post
    I can only give my experience without bloodwork. I've tried tren xtreme and epistane before and prime is not at all the same in regards to shutdown. Yes I did get shutdown a little bit with epistane and more with tren xtreme and had SERMs on hand for that. Doing 2nd run of prime right now and no shutdown at all. Had no problems keeping about 80% of the strength gained from prime. I wouldn't say it was as easy with the DS/PH at all.
    it's a form of tribulus. u can't compare it to epistane and tren products.

  14. Quote Originally Posted by jsp0785 View Post
    it's a form of tribulus. u can't compare it to epistane and tren products.
    Obviously not but I'm comparing any amount of shut down not anabolic or androgenic effects.

  15. Quote Originally Posted by Sub7 View Post
    2 questions:

    1- Some anabolics that do not bind to androgen receptors still cause HTPA shutdown. It is puzzling to me how this happens; I even started a thread in mindandmuscle long time ago to ask specifically this question but got no explanation. My understanding is that nobody really knows how an anabolic drug that causes muscle growth without AR agonism causes shutdown. So do we know for sure that PRIME does not cause shutdown? Any blood tests?
    Yes, there are Class I and Class II steroids, based on their binding affinity to the AR. However, the operative term here is affinity! I say that as, in fact, all steroids bind to the AR on some level, but with a different affinity for inducing mRNA transcription. So, in simpler terms, Class I steroids merely bind harder to the AR, exerting a more direct transcriptional control over the cell; Class II still bind, but probably exert their predominant anabolic effect though transcription upregulation, coactivation factors and so forth. In regards to shutdown, any and all steroids cause shutdown, as they are chemically close enough to Endogenous Testosterone. Yes, we had FSH/LH blood tests done on our Alpha Testers and we will be releasing those.

    2- How did we determine that PRIME does not activate AR?
    We do not. However, we do know that it is not causing any hormonal suppression.

  16. Quote Originally Posted by eatingisfun View Post
    Obviously not but I'm comparing any amount of shut down not anabolic or androgenic effects.
    gotcha

  17. i don't wanna sound like an @ss but wouldn't u want to know exactly how a product worked before you release it to the public?

  18. Quote Originally Posted by jsp0785 View Post
    i don't wanna sound like an @ss but wouldn't u want to know exactly how a product worked before you release it to the public?
    The question is fair and does not make you an "@ss". There is a whole list of compounds in drug-development and production history that are known to be significantly bioactive, although their precise mechanisms of action (MoA) are not known. This does not stop them from being used as active ingredients in different matrices. As a matter of fact, such compounds are highly sought after, as they may lead to significant breakthroughs. We know PRIME works and this has been confirmed by many non-affiliated users. We are also investing resources aimed at understanding its MoA. We will release more details presently.

    Thank you for your interest.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
  19. Guest
    Guest's Avatar

    Quote Originally Posted by jsp0785 View Post
    i don't wanna sound like an @ss but wouldn't u want to know exactly how a product worked before you release it to the public?

    Most supplements are released based off theory not exact MOA. Most supplements are released by companies assuming MOA through a few studies and then releasing it as fact to the public which you can then accept or deny.

    You guys keep beating the wrong drum..

  20. Quote Originally Posted by jsp0785 View Post
    i don't wanna sound like an @ss but wouldn't u want to know exactly how a product worked before you release it to the public?
    go tell big pharm that.

  21. Quote Originally Posted by USPLabs View Post
    Most supplements are released based off theory not exact MOA. Most supplements are released by companies assuming MOA through a few studies and then releasing it as fact to the public which you can then accept or deny.

    You guys keep beating the wrong drum..
    beating the wrong drum? i'm just asking a simple question

  22. Quote Originally Posted by jsp0785 View Post
    beating the wrong drum? i'm just asking a simple question
    No offence meant. Your question has been answered, I suppose. Thank you.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.

  23. Quote Originally Posted by 07zx6r View Post
    go tell big pharm that.
    yes but aren't they required to test them for a few years or so in order to determine it's safe. and i know some bad results are covered up and not so safe products do get out.

  24. Lets say Prime does cause some kind of shut down, would stacking it with something like DTH counteract that?

  25. Quote Originally Posted by TheHunter516 View Post
    Lets say Prime does cause some kind of shut down, would stacking it with something like DTH counteract that?
    The question is hypothetical, as PRIME does not cause any HPTA suppression. Still, PRIME can be stacked with testosterone boosters such as Diesel Test Hardcore.
    Product Educator | USPowders
    Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders’ opinion as a whole.
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