Well, it is a nutrient and not a supplement so I personally don't cycle off. Besides, it doesn't lower your cortisol into the abyss, it just softens the huge spikes I used to get from lifting.
Subjectively, it stops working after some time, meaning that you stop feeling good from it although it still improves recovery as it did from the very beginning. But once loaded, you can go off for a period of time without losing the benefits, which I found out when I ran out once. However, I am still taking my 350mg dose before workout every time. It is quite inexpensive and feasible that way.