FIGHTING CORTISOL: Phosphatidyl Serine
08-13-2008 11:44 PM
FIGHTING CORTISOL: Phosphatidyl Serine
I am not sure if this has been posted before and in how much detail, thought it would be of interest :
Phosphatidyl Serine (1,2-diacyl-sn-glycerol-(3)-L-phosphoserine, PS) is a phospholipid that's comprised of the amino acid L-serine and a lipid molecule. It is essential to the healthy functioning of virtually all cells in our bodies with highest concentrations in the human brain.
While its mechanisms of action are unknown, PS is thought to:
• Repair damaged nerve cells.
• Maintain nerve cell integrity.
• Enhance neurotransmitter signal efficiency.
• Enhance cognition.
• Elevate mood.
• Enhance memory.
• Increase the brains absorption of nutrients.
• Improve nerve cell signal transmission
For athletes and bodybuilders, PS has additional benefits: it works by lowering cortisol levels in response to weight and endurance training. Release of cortisol is stimulated by stress and low blood levels of glucocorticoids. The bad thing for us though is that cortisol increases the rate of protein breakdown as well as removing amino acids from cells and transporting them to the liver to be used for energy. On the positive side though, cortisol makes this energy available when stress levels are high and it also works as an anti inflammatory agent. After a workout, cortisol levels will rise. This excess cortisol is the real problem. The postworkout high cortisol levels break down muscle tissue and block the entry of amino acids into the muscle cells. Ideally, this is the time when you want to take in a high quality protein supplement and some good low GI carbs to speed healing and growth. The trouble is that regardless of the quality of protein you take, when cortisol is high, protein is more apt to be excreted in urine or processed by the liver into glucose. Cortisol also appears to inhibit carbohydrate use. You may have high blood glucose levels, but the glucose may not be transported into the muscle tissue particularly well.
Thus, by taking phosphatidylserine, you may be able to speed recovery times between workouts dramatically. Because cortisol can halt protein synthesis, PS may actually increase your postworkout absorption of amino acids.
Furthermore, unlike other cortisol blockers on the market (like DHEA metabolites, PS is a ‘non-hormonal’ cortisol blocker that can effectively lower cortisol levels. Also, unlike DHEA, rather than lowering testosterone production, PS can actually increase testosterone production.
PS is present in the cells of all plants and animals, and is derived from egg yolks, soybeans or lecithin (phosphatidylcholine). Because the amount of PS that reaches the bloodstream after surviving the intestinal tract is small, results are best observed over time with regular supplementation. The current dosing is around 400 - 800 mg per day, divided in individual doses (4x200mg per day).Do not take PS if you are using amphetamines (recreationally, to treat depression or to treat ADD/ADHD). Do not take PS if you are using adrenergic agonists like dopamine.
08-14-2008 12:36 AM
Primordial Performance Rep
This is a great PS product EndoAmp
08-15-2008 01:22 AM
Originally Posted by MaxGolf
Thanks, I will look into it !
08-15-2008 01:59 AM
I love Phosphatidyl Serine. I do notice a lift in mood and recovery after taking it for a while. Underrated supp imo. Primordial's EndoAamp is one of the best deals you can find on high grade PS. I'll probably take it as long as I can afford to, especially for any post cycle.
08-15-2008 05:30 AM
I was hoping someone would post feedback on EndAmp
Originally Posted by mattikus
How do you dose it and how long after taking it did you notice results ?
08-15-2008 06:03 AM
EndoAmp is still relatively new, so reviews may be sparse. However, you can count on quality when it comes from Primordial Performance. Truely a solid company over there, and I've been very impressed with their products. I'm going to be running EndoAmp for my first time in an upcoming PCT, and I have very high expectations of it.
08-15-2008 10:37 AM
On training days I take a dose before training and one after or before bed. I start to notice benefits within a week. The first time I took PS I didn't really notice much while taking it, but I did when I stopped. I missed the well being and recovery. I seem to notice EndoAmp more than other versions of PS that I have taken, which were of questionable quality.
Originally Posted by dragonfly
08-15-2008 10:45 AM
NutraPlanet NinjaMonkey Rep
The amount of PS in each serving of EndoAmp is quite large (0.8g, + other phospholipids )http://www.nutraplanet.com/product/p...oamp-48-g.html so the price may seem steep but you're getting alot.
08-15-2008 11:02 AM
Bragging here but I got lucky and got a one time sale I could not opass up and got 2 tubs 40% off, don't ask how cause it really was a one time thing when they moved storage facilities but I can't wait to try it for pct...
I think people need to realize that the hormonal nature of lean xtreme and x-lean ect make them things that should not be used in the first few weeks of pct. The companies clain they don't effect the hpta but with enough digging you can find things and studies that show they do. For this reason things like endo amp should be more popular for the first few weeks of pct (my pct's run the entire time I am off because my cycles are long).
08-15-2008 11:13 AM
haha same here man! I SHOULD have grabbed some Sustain Alpha and toco-8 for the kill, but I hesistated. Bad move in hindsight!
Originally Posted by justreading
I agree in how Lean Xtreme/X-Lean cortisol controllers may illicit some undesirable sides. The fact that you should taper to come off usually gives the red flag warning. Not too big of a deal IMO, but EndoAmp or PS for that madder does not need to be tapered. I questioned PP about the optimal tapering schedule, and I was pleased to hear that there is not a rebound upon cessation. Instead, PP informed me that you actually reap the benefits of PS for as many as several weeks after coming off.
08-15-2008 11:41 AM
personally I would run PS with a high grade relora (and for the love of god I can't find one, and no now's is not a high grade for these purposes, see below) because relora is supposed to increase dhea production as well and be cort suppressing.
To be honest i liked Now's at first but some things claim its overal extract is low. It did give me a light relaxed feeling which may have been placebo. The overall extract should be much higher to reall work I think but higher extracts are damn near impossible to find...
Sorry off subject but the nature of Ps lends itself to pct which brought me to relora for dhea stimulation
08-16-2008 06:21 PM
MST Reppin Hard!
I just ordered my first bottle, but by a different company that I trust a lot!
08-16-2008 07:03 PM
Anyone ever notice the size of their waist shrink while on PS? I'm thinking of trying but for the price I want to see/feel more than just subtle effects.
08-16-2008 09:14 PM
I'm still not convinced that currently available PS is all that effective. most of the early studies were on bovine PS, but all that is now available is soy/plant based. I'm not saying it ISNT effective, but that i'm still not sure.
08-16-2008 09:17 PM
Right..and at $50 a pop I don't feel like experimenting.
Originally Posted by EasyEJL
08-16-2008 11:29 PM
MST Reppin Hard!
I am getting the one I will be using for $34 for a month supply and anything i've ever used by the company was 100% quality product.
I will be sure to let you know how it goes for me.
08-17-2008 01:45 AM
True, PS was originally manufactured from the brains of cows, however, because animal brain cells can harbor pathogens (eg BSA, cause of the "mad cow disease"), that form is no longer available. Most PS today is made from soybeans or other plant sources. There are reasons to believe that plant-source PS should function similarly to PS made from cows' brains, and some animal studies suggest that it is indeed effective, mainly in terms of improving memory function (see ref 1-3).
Originally Posted by EasyEJL
There are a number of studies that support the benefits of animal-derived PS supplementation in terms of athletic performance. A double-blind, placebo-controlled study on 11 intensely trained athletes found that 800 mg of PS taken daily reduced the cortisol rise by 20% as compared with placebo (4) Another small study on 9 nonathletic males found that daily doses of 400 and 800 mg of PS reduced cortisol levels after exercise by 16% and 30%, respectively (5).
The effects of non-animal sources of PS in training individuals is controversial, however the nature of responses vary depending on the dosage. For example 750 mg of soy-derived PS improves exercise capacity during cycling (increased time to exhaustion at 85% VO2max), but has no effect on serum cortisol concentration (6). Similarly, administration of 750 mg soy-based PS does not blunt cortisol response and has no effect on markers of muscle damage in runners but it does increase running time to exhaustion (7). However, when given at 400 mg soy PS significantly blunted serum cortisol and ACTH, an effect which was not seen with larger doses of PS (600 and 800 mg respectively, 8).
In conclusion, whichever way you take it you got to experiment, individual biochemistry will dictate the nature of individual responses. In the end, isn’t tweaking with dosages what we do with all performance supplements ? There is no one-size-fits all, unfortunately…
1. Toffano G, Leon A, Benvegnu D. Effect of brain cortex phospholipids on catechol-amine content of mouse brain. Pharmacol Res Commun. 1976;8:581-590.
2. LaBrake CC, Fung LW. Phospholipid vesicles promote human hemoglobin oxidation. J Biol Chem. 1992;267:16703-16711.
3. Orlando P, Cerrito F, Zirili P. The fate of doubly-labelled brain phospholipids administered to mice. Farmaco. 1975;30:451-458.
4. Fahey TD, Pearl M. Hormonal effects of phosphatidylserine during 2 weeks of intense training. Abstract presented at: National Meeting of the American College of Sports Medicine;June, 1998;
5. Monteleone P, Maj M, Beinat L, et al. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamo-pituitary-adrenal axis in healthy men. Eur J Clin Pharmacol. 1992;42:385-388.
6. Kingsley MI, Miller M, Kilduff LP, McEneny J, Benton D. Effects of phosphatidylserine on exercise capacity during cycling in active males. Med Sci Sports Exerc. 2006; 38(1):64-71.
7. Kingsley MI, Wadsworth D, Kilduff LP, McEneny J, Benton D. Effects of phosphatidylserine on oxidative stress following intermittent running. Med Sci Sports Exerc. 2005;37(8):1300-6
8. Hellhammer J, Fries E, Buss C, Engert V, Tuch A, Rutenberg D, Hellhammer D. Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress. Stress. 2004;7(2):119-26.
08-17-2008 09:32 AM
its a pity there are no international sources for bovine based. there was some experimentation with porcine based, but i haven't heard more about it
08-17-2008 09:54 AM
We need primordial perf in here to comment...
08-21-2008 03:14 PM
Running with the Big Boys
Most all the studies that have been done in the last 10 years have been with soy derived PS, and they all show the same benefit as bovine derived PS. (except for one low dose PS study in stress management)
Bovine may be absorbed slightly better, but it’s simply not produced any longer. We can get the same athletic enhancing and cortisol blocking effects from soy derived PS.
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