Vitamin D....

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    Quote Originally Posted by Torobestia View Post
    coop, there's something I'd like to point out about that graph which you may have momentarily forgotten. In statistics, if you have error bars like that that intersect each other at any point between different bars/data points, it means there's no statistical significance. So what one is supposed to get out of that graph is that there is no significant change in either lean mass or fat mass during the experiment.
    I am aware. However, one of my gripes with literature is that statistical significance does not always accurately equate to biological significance. Trending towards an endpoint cannot be ignored if consistently expressed
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    Quote Originally Posted by mr.cooper69 View Post
    statistical significance does not always accurately equate to biological significance.
    I agree. I think it's important to point out, though, that averages like this involve reducing scattered data into simplified bars that don't quite capture the range of the data. That's why the error bars are included. So what those bars are saying is that it's very likely any differences in lean or fat mass gains *are* due to statistical artifacts, not treatments.

    Can real causal relationships be hiding under that? Sure. But it would be inappropriate to draw such conclusions from this kind of data that shows there is no difference between the two groups in changes in these parameters.
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    Quote Originally Posted by Torobestia View Post
    I agree. I think it's important to point out, though, that averages like this involve reducing scattered data into simplified bars that don't quite capture the range of the data. That's why the error bars are included. So what those bars are saying is that it's very likely any differences in lean or fat mass gains *are* due to statistical artifacts, not treatments.

    Can real causal relationships be hiding under that? Sure. But it would be inappropriate to draw such conclusions from this kind of data that shows there is no difference between the two groups in changes in these parameters.
    I don't disagree. Look at it in the context of the present vitamin D data and you'll see where I'm coming from, particularly with respect to fat mass correlations.
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    I get out in the sun a ton already and vit d is so cheap that mothballing my $11 bottle of 400 ct 10000 IU vit d capsules is no big economic loss. You convinced me Coop
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    and the plot thickens...

    Turns out the relationship between supplementing with vitD and getting the cold turns out to be just a correlation and not causative.

    Effect of vitamin D3 supplementation on upper respiratory tract infections in healthy adults: the VIDARIS randomized controlled trial.

    Abstract

    CONTEXT:
    Observational studies have reported an inverse association between serum 25-hydroxyvitamin D (25-OHD) levels and incidence of upper respiratory tract infections (URTIs). However, results of clinical trials of vitamin D supplementation have been inconclusive.

    OBJECTIVE:
    To determine the effect of vitamin D supplementation on incidence and severity of URTIs in healthy adults.

    DESIGN, SETTING, AND PARTICIPANTS:
    Randomized, double-blind, placebo-controlled trial conducted among 322 healthy adults between February 2010 and November 2011 in Christchurch, New Zealand.

    INTERVENTION:
    Participants were randomly assigned to receive an initial dose of 200,000 IU oral vitamin D3, then 200,000 IU 1 month later, then 100,000 IU monthly (n = 161), or placebo administered in an identical dosing regimen (n = 161), for a total of 18 months.

    MAIN OUTCOME MEASURES:
    The primary end point was number of URTI episodes. Secondary end points were duration of URTI episodes, severity of URTI episodes, and number of days of missed work due to URTI episodes.

    RESULTS:
    The mean baseline 25-OHD level of participants was 29 (SD, 9) ng/mL. Vitamin D supplementation resulted in an increase in serum 25-OHD levels that was maintained at greater than 48 ng/mL throughout the study. There were 593 URTI episodes in the vitamin D group and 611 in the placebo group, with no statistically significant differences in the number of URTIs per participant (mean, 3.7 per person in the vitamin D group and 3.8 per person in the placebo group; risk ratio, 0.97; 95% CI, 0.85-1.11), number of days of missed work as a result of URTIs (mean, 0.76 days in each group; risk ratio, 1.03; 95% CI, 0.81-1.30), duration of symptoms per episode (mean, 12 days in each group; risk ratio, 0.96; 95% CI, 0.73-1.25), or severity of URTI episodes. These findings remained unchanged when the analysis was repeated by season and by baseline 25-OHD levels.

    CONCLUSION:
    In this trial, monthly administration of 100,000 IU of vitamin D did not reduce the incidence or severity of URTIs in healthy adults.
    A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections.



    Abstract

    Vitamin D has been shown to be an important immune system regulator. Vitamin D insufficiency during winter may cause increased susceptibility to upper respiratory tract infections (URIs). To determine whether vitamin D supplementation during the winter season prevents or decreases URI symptoms, 162 adults were randomized to receive 50 microg vitamin D3 (2000 IU) daily or matching placebo for 12 weeks. A bi-weekly questionnaire was used to record the incidence and severity of URI symptoms. There was no difference in the incidence of URIs between the vitamin D and placebo groups (48 URIs vs. 50 URIs, respectively, P=0.57). There was no difference in the duration or severity of URI symptoms between the vitamin D and placebo groups [5.4+/-4.8 days vs. 5.3+/-3.1 days, respectively, P=0.86 (95% CI for the difference in duration -1.8 to 2.1)]. The mean 25-hydroxyvitamin D level at baseline was similar in both groups (64.3+/-25.4 nmol/l in the vitamin D group; 63.0+/-25.8 nmol/l in the placebo group; n.s.). After 12 weeks, 25-hydroxyvitamin D levels increased significantly to 88.5+/-23.2 nmol/l in the vitamin D group, whereas there was no change in vitamin D levels in the placebo group. There was no benefit of vitamin D3 supplementation in decreasing the incidence or severity of symptomatic URIs during winter. Further studies are needed to determine the role of vitamin D in infection.
    "The only good is knowledge and the only evil is ignorance." - Socrates
  

  
 

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