Chocolate - an exercise mimetic?

  1. Pro Virili Parte
    Board Sponsor
    JudoJosh's Avatar
    Join Date
    Nov 2008
    Location
    NJ
    Age
    29
    Posts
    8,761
    Rep Power
    2088886

    Chocolate - an exercise mimetic?


    (-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle

    Non-technical summary

    During exercise, skeletal muscle performance depends in great part on the use of aerobic metabolism to supply the energetic demand of contractions. Endurance training increases the muscle aerobic capacity, which is not only associated with enhanced exercise performance, but also with a decreased risk of cardiovascular and metabolic diseases. Recently, it has been shown that regular use of small doses of dark chocolate may result in similar health benefits to exercise training. We show here that mice fed for 15 days with (-)-epicatechin (present in dark chocolate) had improved exercise performance accompanied by: (1) an increased number of capillaries in the hindlimb muscle; and (2) an increased amount of muscle mitochondria as well as signalling for mitochondrial biogenesis. These results suggest that (-)-epicatechin increases the capacity for muscle aerobic metabolism, thereby delaying the onset of fatigue. These findings may have potential application for clinical populations experiencing muscle fatigue.

    Abstract

    The flavanol (-)-epicatechin, a component of cacao (cocoa), has been shown to have multiple health benefits in humans. Using 1-year-old male mice, we examined the effects of 15 days of (-)-epicatechin treatment and regular exercise on: (1) exercise performance, (2) muscle fatigue, (3) capillarity, and (4) mitochondrial biogenesis in mouse hindlimb and heart muscles. Twenty-five male mice (C57BL/6N) were randomized into four groups: (1) water, (2) water-exercise (W-Ex), (3) (-)-epicatechin ((-)-Epi), and (4) (-)-epicatechin-exercise ((-)-Epi-Ex). Animals received 1 mg kg−1 of (-)-epicatechin or water (vehicle) via oral gavage (twice daily). Exercise groups underwent 15 days of treadmill exercise. Significant increases in treadmill performance (∼50%) and enhanced in situ muscle fatigue resistance (∼30%) were observed with (-)-epicatechin. Components of oxidative phosphorylation complexes, mitofilin, porin, nNOS, p-nNOS, and Tfam as well as mitochondrial volume and cristae abundance were significantly higher with (-)-epicatechin treatment for hindlimb and cardiac muscles than exercise alone. In addition, there were significant increases in skeletal muscle capillarity. The combination of (-)-epicatechin and exercise resulted in further increases in oxidative phosphorylation-complex proteins, mitofilin, porin and capillarity than (-)-epicatechin alone. These findings indicate that (-)-epicatechin alone or in combination with exercise induces an integrated response that includes structural and metabolic changes in skeletal and cardiac muscles resulting in greater endurance capacity. These results, therefore, warrant the further evaluation of the underlying mechanism of action of (-)-epicatechin and its potential clinical application as an exercise mimetic.
    FT - http://jp.physoc.org/content/589/18/4615.full#target-3
    "The only good is knowledge and the only evil is ignorance." - Socrates

  2. Registered User
    OrganicShadow's Avatar
    Stats
    5'7"  162 lbs.
    Join Date
    Jun 2010
    Location
    New York NY
    Posts
    2,973
    Rep Power
    251875

    Saw something like this not too long ago can't remember where.
    By believing passionately in something that still does not exist, we create it. The nonexistent is whatever we have not sufficiently desired.
    Franz Kafka

Similar Forum Threads

  1. An exercise for you to try
    By Steelwolf in forum Training Forum
    Replies: 2
    Last Post: 10-22-2010, 04:50 PM
  2. Squats on an exercise ball video
    By tattoopierced1 in forum General Chat
    Replies: 2
    Last Post: 06-03-2009, 02:08 PM
  3. Is there an exercise for the bicep tendons?
    By bombBoogie in forum Exercise Science
    Replies: 4
    Last Post: 06-04-2007, 10:51 AM
  4. 'Ab Vacume' as an exercise
    By Crotalus in forum Exercise Science
    Replies: 9
    Last Post: 03-08-2005, 12:58 PM
  5. Replies: 2
    Last Post: 12-14-2004, 12:29 AM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •  

Log in

Log in

Content Relevant URLs by vBSEO ©2011, Crawlability, Inc.