Sleep Aid??

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    Sleep Aid??


    So, I'm having touble sleeping, if I don't take OTC sleep aids. But I would rather take something a little more healthy than Diphenhydramine HCl! What is reccomended for a quality product, that doesn't kill the pocket?? Thanks,


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    Melatonin for me.

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    Gaba is my favourite, relaxes me alot before bed. Alot of people swear by phenibut, but i don't feel it. BIG is another good one before bed. It has melatonin in it.

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    Quote Originally Posted by Bum Mahoney View Post
    Melatonin for me.

    I was looking at that, it works pretty good? Cheap as hell

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    I take 3g of Melatonin about an hour before bed on nights when I don't think I'll fall asleep right away. Makes me fall asleep quickly and sleep really well. If I take more then 3g of it, it seems to keep me awake.. odd..

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    Quote Originally Posted by aquanutz View Post
    I take 3g of Melatonin about an hour before bed on nights when I don't think I'll fall asleep right away. Makes me fall asleep quickly and sleep really well. If I take more then 3g of it, it seems to keep me awake.. odd..

    What is better; the liquid, pill, or chewable?

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    Melatonin works well, so does Somnidren-GH™.

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    A bottle of jager will do it everytime.

    Just kidding . I really have had very good success with Somnidren-GH, Nocturnabol, The Abyss, and Lean Dreams.

    However, sometimes i'm reduced to diphenhydramine also. It's not something i would do everyday, but it's very effective for me anyway when i need it. The worst part however is the dreaded antihistamine hangover the next day.

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    Quote Originally Posted by mathis50262 View Post
    What is better; the liquid, pill, or chewable?
    I've only ever used a pill.

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    I used valerian to get me through the sleepless nights law school finals induce. It smells like feet but it really works for me and leaves me pretty clear-headed in the morning.

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    Quote Originally Posted by Trauma1 View Post
    A bottle of jager will do it everytime.

    Just kidding . I really have had very good success with Somnidren-GH, Nocturnabol, The Abyss, and Lean Dreams.

    However, sometimes i'm reduced to diphenhydramine also. It's not something i would do everyday, but it's very effective for me anyway when i need it. The worst part however is the dreaded antihistamine hangover the next day.
    I hear you there, it's really bad for me cuz I lift at 5:30 in the morning take two shots of No Xplode, and a Spike to get going

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    Go with somnadren gh, the abyss, PowerFULL, melatonin works pretty good to but gives me nightmares, which I like cause I'm a psycho. but I also have insomnia real bad so I think somnadren gh works the best. Also somatomax which is basicly the same thing as somnadren but a lot more expensive. Good luck Insomnia sux a*&

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    Quote Originally Posted by aquanutz View Post
    I take 3g of Melatonin about an hour before bed on nights when I don't think I'll fall asleep right away. Makes me fall asleep quickly and sleep really well. If I take more then 3g of it, it seems to keep me awake.. odd..
    That is the dose I take as well. I have only used the pills. I found some brand at the drug store that was buy one get one free. Think I spent $12 for over a year's worth. It seems to get me back on a regular sleeping schedule. My doc had prescibed Ambien, which knocked me out, but I would wake in four hours and be wired. I didn't really want a px anyway. Suggested I try this and it has been great. Over a year now.

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    SLEEP AIDS (written by dinoiii):

    Catnip

    BASIC MOA: Nepetalactone isomers are the actives here, somewhat like (BUT NOT EXACTLY) the active ingredients in valerian and mild sedatives.

    EVIDENCE-BASED EFFICACY: A few poorly-controlled studies suggest multiple administrations throughout the day to be an effective dosing pattern which does have the potential to decrease compliance.

    FORMS & DOSAGES: 2-4 grams taken in a titrated up matter to assess tolerance and avoid the potential for groggy "morning-after" feeling.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: None reported to date.


    ______________________________ ________________

    Kava

    BASIC MAO/Chemistry: Extracts of Kava root contain both lipophilic and hydrophilic components. The active components are referred to as kavalactones or kavapyrones. The active enolides + dienolides are thought to be kawain (kavain), methysticin (+ its dihydro active metabolite), and to a lesser extent, yangonin. These active byproducts are hypothesized to do a number of things in the central nervous system (CNS). While it is generally argued to have a MOA unknown, theories have emerged and gained support around this substance. In vitro, kavalactones have been shown to readily bind GABA-A receptors located in the hypothalamus and amygdala, areas thought to be largely responsible for emotion and memory rather than cognition and movement. KAVA may also increase the number of GABA-binding sites. Other suggested mechanisms include reduced excitatory neurotransmission by decreasing the release of glutamate, inhibition of norepinephrine uptake, reversible MAO-B inhibition, or dopamine antagonism. KAVA has also been shown to have mild anticonvulsant properties in animals, possibly involving voltage-dependent sodium channels. There have been reported analgesic effects in humans with animal data suggesting opioid receptors NOT be involved - therefore the jury is still out as to how this effect is seen.

    EVEIDENCE-BASED EFFICACY: This substance has undergone several true well-conducted placebo-controlled trials in Europe and the United States for the treatment of anxiety. Most show significant improvements in anxiety symptoms in patients with moderate to severe anxiety within 8 weeks after starting treatment.

    One study in particular put the supp head-to-head with a leading drug of an equivalent class:
    KAVA vs. Oxazepam (a benzodiazepine) yielded similar reductions in anxiolytic effects BUT fewer adverse effects were seen in the KAVA group.

    FORMS & DOASGES: Unfortunately, KAVA appears to have a slow onset of action for treatment of anxiety (which can extend to similar efficacious results in sedative-promoting effects, at which time many users may give up on the supp attributing their stoppage to its not "working"), most patients only responding after 4-8 weeks of therapy.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: Dinoiii's EXTREME CAUTIONARY WARNING: One of the kavalactones, kavain, has in-vitro COX-inhibitory activity and the potential for antiplatelet and anti-inflammatory effects needs further study.

    ______________________________ ________________

    Chamomile

    BASIC MOA: For purposes of sleep, you may desire to opt for the German/Hungarian variety (there is a Roman variety almost indistinguishable, but alas falls in a different genus and species.).They have tried to isolate the single most active substance in chamomile, with apigenin and other flavones, chamazulene, and a-bisabolol often identified. But most studies have concluded that a whole herb extract is better than any individual phytochemicals. Outside of its insomnia therapy use, chamomile finds use as an anti-inflammatory as well - VERY comparable, if not better than hydrocortsione!

    EVIDENCE-BASED EFFICACY: One study shows induction of a deep sleep in 10 out of 12 cardiac catheterization patients, but otherwise data on a larger scale remains unfortunately deficient.

    FORMS & DOSAGES: Two or three 250mg caps three times per day is what were used in the studies which makes for an exhaustive dosing protocol to follow. If you can keep up with it, however, then by all means.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: None reported, however, cross-reactions may be seen in anyone allergic to ragweed, celery, or aster-family herbs. Again, this is yet another one that should be avoided with NSAIDs, fish oil, vitamin E and other blood thinners due to a coumadin-like property. Minor allergic reactions have been discussed alongside nausea but dosing to induce these symptoms is highly unlikely in most people.

    ______________________________ ________________


    Valerian

    BASIC MOA: The Greeks, beginning with Hippocrates, used valerian roots (translated as phu based on its pugnant smell beneath the surface - i.e. - the root which held the medicinal properties) to help them fall asleep, an application that still holds up under scientific scrutiny. We know conclusively that valerian sedates, quiets the CNS, and minimizes muscle spasms - just like pharmaceutical tranquilizers. After a few thousand years of study, though, we still don't know why. At first, researchers referred to just two phytochemical classes - valeoptriates and the bornyl esters as contributing to 100% of the active properties, now we know there are at least several more - valeranone and the kessyl esters. Another example of the whole herb being better than the sum of its parts.

    EVIDENCE-BASED EFFICACY: Combined with St. John's Wort, Valerian bested diazepam (Valium) in a 2-week trial involving 100 people being treated for anxiety. A different double-blind coupled Valerian with hops (see above) showing superiority to triazolam (Halcion), another benzodiazepine, for relieving sleep disorders. When I mention superiority here, the results on efficacy were not what contributed to that dubbing - as efficacy was NOT statistically significant in its difference. However, the safety (i.e. - less side effects associated with the non-habit-forming supplements) profile is what allows for superior rating.

    FORMS & DOSAGES: About 300-500 mg of standardized extract before bedtime. 1, 425-2,780 mg of non-standardized supplement for insomnia relief before bed.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: Hepatotoxicity (liver toxicity) has been reported in a few multi-herb preparation formulas. It remains unclear as to whether this side effect is evident with Valerian alone. A compound called scullcap is usually the culprit I think - because the more hepatotoxic herb germander is often mistakenly harvested as scullcap. Furthermore, reports on 50 cases of overdose with a combination preparation containing hyoscine, cyproheptadine, and valerian indicated the expected symptoms of cyproheptadine and hyoscine toxicity, but no signs of hepatotoxicity developed in the short or long term.

    Mild, transient stomach upset as well as nausea and vomiting have been reported anecdotally. Large doses may be associated with decreased intestinal motility - perhaps offsetting some of the appetite stimulating effects of hops when used in combo.

    Valerian has also been reported to cause headache, excitability, insomnia, uneasiness, ataxia, and hypothermia, although the level of adverse effects reported in clinical trials has not been greater than for a placebo. Short-term mild impairments in vigilance, concentration, and processing time for complex thoughts, as well as mild fatigue, have been reported in trials (lasting for several hours), although residual sedative effects appear to be less pronounced than those for benzos (i.e. - no hangover drowsiness). The problem is that preliminary evidence suggests that valerian is non-sedating in recommended doses. With higher dosing protocols, the evolution of this "hangover" effect cannot be excluded. Chronic high-dose actually leads to a similar "Valerian withdrawl" similar to that seen with benzos. Delirium, ameliorated by benzos, was reported in a single patient undergoing withdrawl from high-dose valerian. Dizziness and headache have been reported rarely in human studies. Anecdotally, some people may develop a "paradoxical reaction" leading to nervousness or excitability.



    Sleep Aids
    Melatonin: ++ (long-term use)
    Catnip: +
    Kava: +++ , – (w/ NSAIDs, fish oil, Vit E)
    Chamomile: ++ , – (w/ NSAIDs, fish oil, Vit E)
    Valerian: +++ (high dose, short-term, proper taper), + (low dose, short term, proper taper), – (high dose, long-term, proper taper), – (high dose, short-term, abrupt cessation), – (w/ various interacting agents listed above)

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    Quote Originally Posted by rabican View Post
    SLEEP AIDS (written by dinoiii):

    Catnip

    BASIC MOA: Nepetalactone isomers are the actives here, somewhat like (BUT NOT EXACTLY) the active ingredients in valerian and mild sedatives.

    EVIDENCE-BASED EFFICACY: A few poorly-controlled studies suggest multiple administrations throughout the day to be an effective dosing pattern which does have the potential to decrease compliance.

    FORMS & DOSAGES: 2-4 grams taken in a titrated up matter to assess tolerance and avoid the potential for groggy "morning-after" feeling.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: None reported to date.


    ______________________________ ________________

    Kava

    BASIC MAO/Chemistry: Extracts of Kava root contain both lipophilic and hydrophilic components. The active components are referred to as kavalactones or kavapyrones. The active enolides + dienolides are thought to be kawain (kavain), methysticin (+ its dihydro active metabolite), and to a lesser extent, yangonin. These active byproducts are hypothesized to do a number of things in the central nervous system (CNS). While it is generally argued to have a MOA unknown, theories have emerged and gained support around this substance. In vitro, kavalactones have been shown to readily bind GABA-A receptors located in the hypothalamus and amygdala, areas thought to be largely responsible for emotion and memory rather than cognition and movement. KAVA may also increase the number of GABA-binding sites. Other suggested mechanisms include reduced excitatory neurotransmission by decreasing the release of glutamate, inhibition of norepinephrine uptake, reversible MAO-B inhibition, or dopamine antagonism. KAVA has also been shown to have mild anticonvulsant properties in animals, possibly involving voltage-dependent sodium channels. There have been reported analgesic effects in humans with animal data suggesting opioid receptors NOT be involved - therefore the jury is still out as to how this effect is seen.

    EVEIDENCE-BASED EFFICACY: This substance has undergone several true well-conducted placebo-controlled trials in Europe and the United States for the treatment of anxiety. Most show significant improvements in anxiety symptoms in patients with moderate to severe anxiety within 8 weeks after starting treatment.

    One study in particular put the supp head-to-head with a leading drug of an equivalent class:
    KAVA vs. Oxazepam (a benzodiazepine) yielded similar reductions in anxiolytic effects BUT fewer adverse effects were seen in the KAVA group.

    FORMS & DOASGES: Unfortunately, KAVA appears to have a slow onset of action for treatment of anxiety (which can extend to similar efficacious results in sedative-promoting effects, at which time many users may give up on the supp attributing their stoppage to its not "working"), most patients only responding after 4-8 weeks of therapy.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: Dinoiii's EXTREME CAUTIONARY WARNING: One of the kavalactones, kavain, has in-vitro COX-inhibitory activity and the potential for antiplatelet and anti-inflammatory effects needs further study.

    ______________________________ ________________

    Chamomile

    BASIC MOA: For purposes of sleep, you may desire to opt for the German/Hungarian variety (there is a Roman variety almost indistinguishable, but alas falls in a different genus and species.).They have tried to isolate the single most active substance in chamomile, with apigenin and other flavones, chamazulene, and a-bisabolol often identified. But most studies have concluded that a whole herb extract is better than any individual phytochemicals. Outside of its insomnia therapy use, chamomile finds use as an anti-inflammatory as well - VERY comparable, if not better than hydrocortsione!

    EVIDENCE-BASED EFFICACY: One study shows induction of a deep sleep in 10 out of 12 cardiac catheterization patients, but otherwise data on a larger scale remains unfortunately deficient.

    FORMS & DOSAGES: Two or three 250mg caps three times per day is what were used in the studies which makes for an exhaustive dosing protocol to follow. If you can keep up with it, however, then by all means.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: None reported, however, cross-reactions may be seen in anyone allergic to ragweed, celery, or aster-family herbs. Again, this is yet another one that should be avoided with NSAIDs, fish oil, vitamin E and other blood thinners due to a coumadin-like property. Minor allergic reactions have been discussed alongside nausea but dosing to induce these symptoms is highly unlikely in most people.

    ______________________________ ________________


    Valerian

    BASIC MOA: The Greeks, beginning with Hippocrates, used valerian roots (translated as phu based on its pugnant smell beneath the surface - i.e. - the root which held the medicinal properties) to help them fall asleep, an application that still holds up under scientific scrutiny. We know conclusively that valerian sedates, quiets the CNS, and minimizes muscle spasms - just like pharmaceutical tranquilizers. After a few thousand years of study, though, we still don't know why. At first, researchers referred to just two phytochemical classes - valeoptriates and the bornyl esters as contributing to 100% of the active properties, now we know there are at least several more - valeranone and the kessyl esters. Another example of the whole herb being better than the sum of its parts.

    EVIDENCE-BASED EFFICACY: Combined with St. John's Wort, Valerian bested diazepam (Valium) in a 2-week trial involving 100 people being treated for anxiety. A different double-blind coupled Valerian with hops (see above) showing superiority to triazolam (Halcion), another benzodiazepine, for relieving sleep disorders. When I mention superiority here, the results on efficacy were not what contributed to that dubbing - as efficacy was NOT statistically significant in its difference. However, the safety (i.e. - less side effects associated with the non-habit-forming supplements) profile is what allows for superior rating.

    FORMS & DOSAGES: About 300-500 mg of standardized extract before bedtime. 1, 425-2,780 mg of non-standardized supplement for insomnia relief before bed.

    POTENTIAL SIDE EFFECTS/INTERACTIONS: Hepatotoxicity (liver toxicity) has been reported in a few multi-herb preparation formulas. It remains unclear as to whether this side effect is evident with Valerian alone. A compound called scullcap is usually the culprit I think - because the more hepatotoxic herb germander is often mistakenly harvested as scullcap. Furthermore, reports on 50 cases of overdose with a combination preparation containing hyoscine, cyproheptadine, and valerian indicated the expected symptoms of cyproheptadine and hyoscine toxicity, but no signs of hepatotoxicity developed in the short or long term.

    Mild, transient stomach upset as well as nausea and vomiting have been reported anecdotally. Large doses may be associated with decreased intestinal motility - perhaps offsetting some of the appetite stimulating effects of hops when used in combo.

    Valerian has also been reported to cause headache, excitability, insomnia, uneasiness, ataxia, and hypothermia, although the level of adverse effects reported in clinical trials has not been greater than for a placebo. Short-term mild impairments in vigilance, concentration, and processing time for complex thoughts, as well as mild fatigue, have been reported in trials (lasting for several hours), although residual sedative effects appear to be less pronounced than those for benzos (i.e. - no hangover drowsiness). The problem is that preliminary evidence suggests that valerian is non-sedating in recommended doses. With higher dosing protocols, the evolution of this "hangover" effect cannot be excluded. Chronic high-dose actually leads to a similar "Valerian withdrawl" similar to that seen with benzos. Delirium, ameliorated by benzos, was reported in a single patient undergoing withdrawl from high-dose valerian. Dizziness and headache have been reported rarely in human studies. Anecdotally, some people may develop a "paradoxical reaction" leading to nervousness or excitability.



    Sleep Aids
    Melatonin: ++ (long-term use)
    Catnip: +
    Kava: +++ , (w/ NSAIDs, fish oil, Vit E)
    Chamomile: ++ , (w/ NSAIDs, fish oil, Vit E)
    Valerian: +++ (high dose, short-term, proper taper), + (low dose, short term, proper taper), (high dose, long-term, proper taper), (high dose, short-term, abrupt cessation), (w/ various interacting agents listed above)

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    Quote Originally Posted by Kirkatis View Post
    Go with somnadren gh, the abyss, PowerFULL, melatonin works pretty good to but gives me nightmares, which I like cause I'm a psycho. but I also have insomnia real bad so I think somnadren gh works the best. Also somatomax which is basicly the same thing as somnadren but a lot more expensive. Good luck Insomnia sux a*&
    Powerfull is definitely good stuff for sleep as well.

    Evolutionary Muse - Inspire to Evolve
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    I just ordered melatonin, damn that stuff is cheap! Hope it works, if not I'll just work my way up in price.

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    Good luck. Give it 1/2 hour to an hour before you want to crash....

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    I have had trouble with sleep in the past and tried melatonin, GABA, and OTC's with very little success. Then I tried ZMA from NOW and it works great! Puts me to sleep quick and keeps me there at least seven hours, wake up with no hangover. Only about ten bucks a month..

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    So do you get really good sleep if you stack melatonin with ZMA?

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    Melatonin didn't do much for me besides give me a hungover feeling for most of the next day but everyone reacts differently. If the Melatonin works for you thats great but if not then the ZMA is another low cost option that works well. You could take both BUT you may feel a little out of sorts the next day.

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    So, I'm kinda new to the whole "Bodybuilding". I have lifted for several years, but not on the strict diet and lifting hardcore like I am now. Ran a cycle of C-50 thats when the sleeplessness kicked in, is this something that all bodybuilders deal with? Does anyone else just lay in bed and think about lifting??

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    you can also try ZMT

    ...melatonin ALWAYS works for me.
    Kava also helps...i want to try GABA next...

    i have this tea called sleepy time tea, it has hops, catnip, and camomeal i believe, it also helps...

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    My mom is a herbal doctor so she is whipping me up something with valerian in it, along with some other herbs, I'm going to give that a shot! Also she is going to make me a pre workout formula, mental focus, alertness, and drive?? Just have to see!

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    Sounds cool. You'll have to tell us what herbs and the effects you get from it.

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    The budget choice is Nocturnabol. The baller choice is Somnidren-GH.

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    Quote Originally Posted by Kirkatis View Post
    Sounds cool. You'll have to tell us what herbs and the effects you get from it.
    Hey kirkitas I will defanitly do that, she will be making it up this weekend so when it arrives I let you know whats in it and what it does!

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    300mg Relora, 3mg Melatonin

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    I use Power to Sleep by Irwin Nutrition. It has been working good so far.

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    Quote Originally Posted by mathis50262 View Post
    Hey kirkitas I will defanitly do that, she will be making it up this weekend so when it arrives I let you know whats in it and what it does!
    Right on keep me informed sounds interesting. This is my new stack I am planning on logging
    HemodrauliX (180 Liquid Softgels)
    By: Axis Labs
    In Stock ! $39.99 $39.99

    Acetyl L-Carnitine (500 grams)
    By: NutraPlanet
    In Stock ! $24.95 $24.95

    1,3-dimethylamylamine Caps
    By: NutraPlanet
    In Stock ! $25.00 $25.00

    Tricreatine Malate (100 grams)
    By: NutraPlanet
    In Stock ! $2.95 $2.95

    CLA Supreme Caps (100 softgels)
    By: NutraPlanet
    In Stock ! $6.99 $6.99

    RPM (110 capsules)
    By: Applied Nutriceuticals
    In Stock ! $29.95 $29.95
    and applied was generous enough to add in a free bottle of Drive so it is gonna be war at the gym. I can't wait

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    Quote Originally Posted by Kirkatis View Post
    Right on keep me informed sounds interesting. This is my new stack I am planning on logging
    HemodrauliX (180 Liquid Softgels)
    By: Axis Labs
    In Stock ! $39.99 $39.99

    Acetyl L-Carnitine (500 grams)
    By: NutraPlanet
    In Stock ! $24.95 $24.95

    1,3-dimethylamylamine Caps
    By: NutraPlanet
    In Stock ! $25.00 $25.00

    Tricreatine Malate (100 grams)



    CLA Supreme Caps (100 softgels)
    By: NutraPlanet
    In Stock ! $6.99 $6.99

    RPM (110 capsules)
    By: Applied Nutriceuticals
    In Stock ! $29.95 $29.95
    and applied was generous enough to add in a free bottle of Drive so it is gonna be war at the gym. I can't wait

    Nice bro, will you post you link to your log on this page when you start so I can follow!

  32. New Member
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    Quote Originally Posted by Bum Mahoney View Post
    Melatonin for me.
    Goooooooooooooo Pens!!!!!!!!! **** the red wings!!!!!!!

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    you could try knockout.

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    igf2 from AN and melatonin at 1.5mg...If i take 3mg, I will not fall asleep until 45mins later, but with 3 ifg2 and 1.5mg(half a pill), I normally fall asleep in 20mins or less.

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    Quote Originally Posted by mathis50262 View Post
    Nice bro, will you post you link to your log on this page when you start so I can follow!
    got you if nutra would hurry up and send it.

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    I'm in the same boat!


    I have a hard time getting to sleep too and I also take Diphenhydramine HCl - night. I can't wake up the next day and, like you, take no-xplode or caffeine pills to wake up. Not a good cycle. I ordered ZMT from Nutraplanet and it should be here tomorrow. I'll let you know if it works for me.
    How's the melatonin working for you?

  37. Advanced Member
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    Melitonan works great along with a little valerian!

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