Nettle Root increases DHT

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    Nettle Root increases DHT


    Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

    Planta Med. 1997 Dec;63(6):529-32.
    Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).


  2. Quote Originally Posted by USPLabs View Post
    Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

    Planta Med. 1997 Dec;63(6):529-32.
    Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
    This suggests that Nettle possesses a greater ANDROGENIC effect than previously thought.

    Nettle also increases FREE Testosterone, also increasing the conversion of testosterone to DHT via the 5a-Reductase enzyme.

  3. Bloodwork supports the science.
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  4. how come all the research ive seen says nettle root lowers dht converson from testosterone???

  5. Quote Originally Posted by Designer Supps View Post
    Bloodwork supports the science.
    Agreed.

  6. uhhh ok doesnt really explane anything but ok then maybe someone else will have the science behind this instead of quoting and just saying what the OTHER sponcer said hah

  7. Quote Originally Posted by madEnuff View Post
    uhhh ok doesnt really explane anything but ok then maybe someone else will have the science behind this instead of quoting and just saying what the OTHER sponcer said hah
    He is saying that based on the bloodowork(that he has seen), nettle does indeed increase DHT.

    Unless I misunderstood.

  8. Quote Originally Posted by SupremeSE View Post
    He is saying that based on the bloodowrk(that he has seen), nettle does indeed increase DHT.

    Unless I misunderstood.
    Thats exactly what I mean. Nettle blocks the binding of dht at the scalp and prostate. Maybe that is the studies you are thinking of when lowering DHT?

    Overall DHT is increased but only where you want it increased, muscle tissue. This also explains why users report strength going up so much when using it.

    Bloodwork that Ive had done and seen support all of the research on it. So not only does it work in the lab but it works in exercising males as well.

  9. Quote Originally Posted by Designer Supps View Post
    Thats exactly what I mean. Nettle blocks the binding of dht at the scalp and prostate. Maybe that is the studies you are thinking of when lowering DHT?

    Overall DHT is increased but only where you want it increased, muscle tissue. This also explains why users report strength going up so much when using it.

    Bloodwork that Ive had done and seen support all of the research on it. So not only does it work in the lab but it works in exercising males as well.
    That explains the strength and vascularity aspects of it.
    M.Ed. Ex Phys


  10. Quote Originally Posted by Rodja View Post
    That explains the strength and vascularity aspects of it.
    Exactly.

  11. Quote Originally Posted by Designer Supps View Post
    Exactly.
    Cheers for an awesome and innovative product, DS.
    M.Ed. Ex Phys


  12. Quote Originally Posted by Rodja View Post
    Cheers for an awesome and innovative product, DS.
    Big bump for Designer Supps!

  13. Quote Originally Posted by USPLabs View Post
    Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

    Planta Med. 1997 Dec;63(6):529-32.
    Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

    Al tho I didn't know this I completely believe it. I did loose hair when I used activate and it hasn't grown back. I completely agree that it does increase dht in the scalp. I wish I had known this before. I would have never used it cause the hair still hasn't grown back to how it was before.

    But I am also prone mpb so that made it even worse but now I know to stay away from any product containing this, im barely over 21 and I dont wanna make it worse. Thanks for informing us on this, I really did loose hair on the top back of my head around the exact time I used this so I def aggravated my genetic mpb.
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    Quote Originally Posted by Designer Supps View Post
    Thats exactly what I mean. Nettle blocks the binding of dht at the scalp and prostate. Maybe that is the studies you are thinking of when lowering DHT?

    Overall DHT is increased but only where you want it increased, muscle tissue. This also explains why users report strength going up so much when using it.

    Bloodwork that Ive had done and seen support all of the research on it. So not only does it work in the lab but it works in exercising males as well.
    Really?

    the prostate and scalp are not the same tissues, just as they are not skeletal muscle. Nettle does not block the binding of DHT in the scalp. It's also not that DHT is actually being blocked in the prostate anyhow, rather, it's an inhibition of SHBG from binding to the prostatic membrane receptors. It has nothing to do with DHT actually being blocked itself.

  15. Quote Originally Posted by WebDesigner View Post
    Al tho I didn't know this I completely believe it. I did loose hair when I used activate and it hasn't grown back. I completely agree that it does increase dht in the scalp. I wish I had known this before. I would have never used it cause the hair still hasn't grown back to how it was before.

    But I am also prone mpb so that made it even worse but now I know to stay away from any product containing this, im barely over 21 and I dont wanna make it worse. Thanks for informing us on this, I really did loose hair on the top back of my head around the exact time I used this so I def aggravated my genetic mpb.
    Interesting. As matt alluded to above, Nettle blocks DHT from binding at the scalp/prostate. Although I'm not discounting that you lost hair, it is far less common with Activate than other test boosters that do not have Divanil.
    NSCA-CSCS and CPT - Pursuing DPT Degree
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    Quote Originally Posted by SupremeSE View Post
    This suggests that Nettle possesses a greater ANDROGENIC effect than previously thought.

    Nettle also increases FREE Testosterone, also increasing the conversion of testosterone to DHT via the 5a-Reductase enzyme.
    Muscle tissue? Muscle tissue has little to no 5 alpha-reductase activity so there is no conversion of T to DHT in that tissue.

  17. Quote Originally Posted by USPLabs View Post
    Muscle tissue? Muscle tissue has little to no 5 alpha-reductase activity so there is no conversion of T to DHT in that tissue.
    Who said anything about muscle-tissue?

    Increased circulatory levels of DHT lead to increased Andorgenic effect.

  18. Quote Originally Posted by SupremeSE View Post
    This suggests that Nettle possesses a greater ANDROGENIC effect than previously thought.

    Nettle also increases FREE Testosterone, also increasing the conversion of testosterone to DHT via the 5a-Reductase enzyme.
    I think he was alluding to this statement, which seemed to corroborate with your first sentence.

    (in a muscular context)
  19. Guest
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    Quote Originally Posted by SupremeSE View Post
    Who said anything about muscle-tissue?

    Increased circulatory levels of DHT lead to increased Andorgenic effect.

    Lord....nevermind, you are full of Gibberish.

  20. Quote Originally Posted by USPLabs View Post
    Lord....nevermind, you are full of Gibberish.
    is it safe to say you don't like me?

    Was it the original Vicodene thread?

    I was an ass...I am sorry.

    Our approach was wrong. VERY wrong.
  21. Guest
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    Quote Originally Posted by SupremeSE View Post
    is it safe to say you don't like me?

    Was it the original Vicodene thread?

    I was an ass...I am sorry.

    Our approach was wrong. VERY wrong.
    You may be a great human, but your marketing approach is terrible.

    I extended my advice and experience to you initially. You just decided against taking it.

    I rather see you succeed than fail.

  22. No wonder nettle killed my hairline.

  23. I'm confused. Will stinging nettle actually increase DHT or not?

    Do users experience increased beard growth for example?

  24. Quote Originally Posted by haiz69 View Post
    Interesting. As matt alluded to above, Nettle blocks DHT from binding at the scalp/prostate. Although I'm not discounting that you lost hair, it is far less common with Activate than other test boosters that do not have Divanil.
    What other test boosters would cause hair loss and for what reason?

  25. Quote Originally Posted by SupremeSE View Post
    Agreed.
    ...always and forever

  26. This is an interesting little conversation. It's a little confusing, though, as the study seems to indicate more potential bonding at the scalp, where as Matt seems insistant that is is less likely. NOrmally I go straight with the study, but Matt is the diavinil guy. Of course, he also has a vested interest in it. I'll just keep an open mind.

  27. I believe it. When I was taking Activate, one of the main effects that I saw was increased beard growth. I was sportin' a biker gottee for a few months.

  28. Quote Originally Posted by Dr. Lats View Post
    I believe it. When I was taking Activate, one of the main effects that I saw was increased beard growth. I was sportin' a biker gottee for a few months.
    Haha, I noticed this too.
    NSCA-CSCS and CPT - Pursuing DPT Degree

  29. Clean shaven to santa clause in T-minus 2 days...

  30. Divanil....mmmmm.

    Hair is for women, unless its on a chest/arm pits/back, then stay the **** away from that woman.

  31. Quote Originally Posted by USPLabs View Post
    Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

    Planta Med. 1997 Dec;63(6):529-32.
    Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
    This is cool. I always stayed away from Nettle because I thought it lowered DHT and I like DHT. I might give it another shot. Maybe this is the reason so many people report a libido increase while using it. So, If DHT is raised then the body
    would have less active Estrodiol and Progesterone? Maybe a new marketing avenue?

  32. Quote Originally Posted by Dr. Lats View Post
    I believe it. When I was taking Activate, one of the main effects that I saw was increased beard growth. I was sportin' a biker gottee for a few months.

    Jungle Warfare has the same extract and I got the same sides, more and thicker body/facial hair and lots of shedding which is still continuing like 2 months after a 3 week run with JW

  33. Quote Originally Posted by Hyde12 View Post
    This is cool. I always stayed away from Nettle because I thought it lowered DHT and I like DHT. I might give it another shot. Maybe this is the reason so many people report a libido increase while using it. So, If DHT is raised then the body
    would have less active Estrodiol and Progesterone? Maybe a new marketing avenue?
    I'm was in the same boat with you HYDE. I thought Nettle lowered DHT and quit using it long ago. I know that my strength went up as well as libido while using it. I just attributed it to other products I was taking at the time like Icariin and LongJack. I'll have to give bulk Divanil another try it seems. Great thread!! THE THUNDERGOD

  34. So much for using this in PCT.

  35. Quote Originally Posted by Al Shades View Post
    So much for using this in PCT.
    Why not? It lowers DHT in the prostate, but increases free DHT and therefore libido.

  36. I got some Divanil for my upcoming cycle's PCT but I don't plan to use it until about day 15. I figure since it helps free up test, and at beginning there not much test to free up day 15 should be good.

  37. Quote Originally Posted by Ziquor View Post
    I got some Divanil for my upcoming cycle's PCT but I don't plan to use it until about day 15. I figure since it helps free up test, and at beginning there not much test to free up day 15 should be good.
    I feel that divanil actually takes 7 to 10 days to start building up in my system. It's after this that I start to feel its effects. I would start taking it the very first day of PCT if it were me. Then after the first week of PCT, you'll be feeling it! Just my little $.02 !! THE THUNDERGOD

  38. Quote Originally Posted by thundergod View Post
    I feel that divanil actually takes 7 to 10 days to start building up in my system. It's after this that I start to feel its effects. I would start taking it the very first day of PCT if it were me. Then after the first week of PCT, you'll be feeling it! Just my little $.02 !! THE THUNDERGOD
    Interesting, thanks Thunder. How about maybe running it at about half dosed at the start of PCT, then after a week kickin it up a notch?

  39. Quote Originally Posted by Ziquor View Post
    Interesting, thanks Thunder. How about maybe running it at about half dosed at the start of PCT, then after a week kickin it up a notch?
    I would just run it full strength. It builds up in your system it seems. If you like the fact that it increases DHT (and I love DHT!), you might want to run some 6-oxo in your PCT as well. After 6 weeks of 600 mg. of 6-oxo per day, the blood work showed a doubling of free testosterone, and a TRIPLING of DHT!! I run mine in a transdermal, so I only have to use 150 mg. of it per day. Much cheaper than oral. And works better too!! THE THUNDERGOD

  40. Quote Originally Posted by thundergod View Post
    I would just run it full strength. It builds up in your system it seems. If you like the fact that it increases DHT (and I love DHT!), you might want to run some 6-oxo in your PCT as well. After 6 weeks of 600 mg. of 6-oxo per day, the blood work showed a doubling of free testosterone, and a TRIPLING of DHT!! I run mine in a transdermal, so I only have to use 150 mg. of it per day. Much cheaper than oral. And works better too!! THE THUNDERGOD
    Holy ****, those are some nice #'s. I don't mind DHT as long as I'm not running straight Mestanolone. This was a good thread I'm glad it got bumped after all that time or I never would've seen it.
  

  
 

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