Nettle Root increases DHT

USPLabs · 03-01-2008, 12:34 PM

Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

Planta Med. 1997 Dec;63(6):529-32.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

SupremeSE · 03-01-2008, 01:17 PM

Quote:

Originally Posted by USPLabs

Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

Planta Med. 1997 Dec;63(6):529-32.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

This suggests that Nettle possesses a greater ANDROGENIC effect than previously thought.

Nettle also increases FREE Testosterone, also increasing the conversion of testosterone to DHT via the 5a-Reductase enzyme.

Sldge · 03-01-2008, 02:35 PM

Bloodwork supports the science.

madEnuff · 03-01-2008, 02:36 PM

how come all the research ive seen says nettle root lowers dht converson from testosterone???

SupremeSE · 03-01-2008, 02:37 PM

Quote:

Originally Posted by Designer Supps

Bloodwork supports the science.

Agreed.

madEnuff · 03-01-2008, 02:49 PM

uhhh ok doesnt really explane anything but ok then maybe someone else will have the science behind this instead of quoting and just saying what the OTHER sponcer said hah

SupremeSE · 03-01-2008, 02:59 PM

Quote:

Originally Posted by madEnuff

uhhh ok doesnt really explane anything but ok then maybe someone else will have the science behind this instead of quoting and just saying what the OTHER sponcer said hah

He is saying that based on the bloodowork(that he has seen), nettle does indeed increase DHT.

Unless I misunderstood.

Sldge · 03-01-2008, 03:08 PM

Quote:

Originally Posted by SupremeSE

He is saying that based on the bloodowrk(that he has seen), nettle does indeed increase DHT.

Unless I misunderstood.

Thats exactly what I mean. Nettle blocks the binding of dht at the scalp and prostate. Maybe that is the studies you are thinking of when lowering DHT?

Overall DHT is increased but only where you want it increased, muscle tissue. This also explains why users report strength going up so much when using it.

Bloodwork that Ive had done and seen support all of the research on it. So not only does it work in the lab but it works in exercising males as well.

Rodja · 03-01-2008, 03:33 PM

Quote:

Originally Posted by Designer Supps

Thats exactly what I mean. Nettle blocks the binding of dht at the scalp and prostate. Maybe that is the studies you are thinking of when lowering DHT?

Overall DHT is increased but only where you want it increased, muscle tissue. This also explains why users report strength going up so much when using it.

Bloodwork that Ive had done and seen support all of the research on it. So not only does it work in the lab but it works in exercising males as well.

That explains the strength and vascularity aspects of it.

Sldge · 03-01-2008, 03:42 PM

Quote:

Originally Posted by Rodja

That explains the strength and vascularity aspects of it.

Exactly.

Rodja · 03-01-2008, 03:47 PM

Quote:

Originally Posted by Designer Supps

Exactly.

Cheers for an awesome and innovative product, DS.

SupremeSE · 03-01-2008, 03:50 PM

Quote:

Originally Posted by Rodja

Cheers for an awesome and innovative product, DS.

Big bump for Designer Supps!

WebDesigner · 03-01-2008, 04:29 PM

Quote:

Originally Posted by USPLabs

Secoisolariciresinol, a lignan in nettle root displayed a modest inhibitory effect on DHT binding to SHBG in vitro, theoretically resulting in greater concentrations of free DHT in serum and in local tissues. The lignan 3,4-divanillyltetrahydrofuran, also present in nettle root was able to completely inhibit DHT from binding to SHBG, yet another indication that it can result in increased free (active) DHT available to tissues such as that in the scalp.

Planta Med. 1997 Dec;63(6):529-32.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).

Al tho I didn't know this I completely believe it. I did loose hair when I used activate and it hasn't grown back. I completely agree that it does increase dht in the scalp. I wish I had known this before. I would have never used it cause the hair still hasn't grown back to how it was before.

But I am also prone mpb so that made it even worse but now I know to stay away from any product containing this, im barely over 21 and I dont wanna make it worse. Thanks for informing us on this, I really did loose hair on the top back of my head around the exact time I used this so I def aggravated my genetic mpb.

USPLabs · 03-01-2008, 04:36 PM

Quote:

Originally Posted by Designer Supps

Thats exactly what I mean. Nettle blocks the binding of dht at the scalp and prostate. Maybe that is the studies you are thinking of when lowering DHT?

Overall DHT is increased but only where you want it increased, muscle tissue. This also explains why users report strength going up so much when using it.

Bloodwork that Ive had done and seen support all of the research on it. So not only does it work in the lab but it works in exercising males as well.

Really?

the prostate and scalp are not the same tissues, just as they are not skeletal muscle. Nettle does not block the binding of DHT in the scalp. It's also not that DHT is actually being blocked in the prostate anyhow, rather, it's an inhibition of SHBG from binding to the prostatic membrane receptors. It has nothing to do with DHT actually being blocked itself.

haiz69 · 03-01-2008, 04:38 PM

Quote:

Originally Posted by WebDesigner

Al tho I didn't know this I completely believe it. I did loose hair when I used activate and it hasn't grown back. I completely agree that it does increase dht in the scalp. I wish I had known this before. I would have never used it cause the hair still hasn't grown back to how it was before.

But I am also prone mpb so that made it even worse but now I know to stay away from any product containing this, im barely over 21 and I dont wanna make it worse. Thanks for informing us on this, I really did loose hair on the top back of my head around the exact time I used this so I def aggravated my genetic mpb.

Interesting. As matt alluded to above, Nettle blocks DHT from binding at the scalp/prostate. Although I'm not discounting that you lost hair, it is far less common with Activate than other test boosters that do not have Divanil.

USPLabs · 03-01-2008, 04:38 PM

Quote:

Originally Posted by SupremeSE

This suggests that Nettle possesses a greater ANDROGENIC effect than previously thought.

Nettle also increases FREE Testosterone, also increasing the conversion of testosterone to DHT via the 5a-Reductase enzyme.

Muscle tissue? Muscle tissue has little to no 5 alpha-reductase activity so there is no conversion of T to DHT in that tissue.

SupremeSE · 03-01-2008, 04:40 PM

Quote:

Originally Posted by USPLabs

Muscle tissue? Muscle tissue has little to no 5 alpha-reductase activity so there is no conversion of T to DHT in that tissue.