FEATURE ARTICLE
-GHRP-6 and Hexarelin
By Anthony Roberts
Earlier this year, I was interviewed by a major online bodybuilding site (the
interview was titled “Chemically Insane”), and in that interview, I
predicted that various peptides would become the newest trend in performance
enhancing drugs. For the most part, I was correct, and now they’re very
popular and widely available, although still relatively new.
So, several months ago, I began my experimentation with various peptides, mostly
with the goal of figuring out the best way to use them. My last major article
examined my experiences with the two most popular peptides (IGF and MGF)
currently on the market. This time around, I’m going to tell you about my
experience with Hexarelin and GHRP-6, two lesser known peptides. With Lr3IGF-1,
the use and goals of use is pretty straightforward…you pretty much use it to
gain muscle and lose fat; on rare occasions, people use it to rehab an injury (I
actually provided a full rehab protocol using IGF-1 in my first e-book). With
MGF, it’s even simpler…you use it to increase muscle size, period.
Using the other peptides is a bit more complicated, and there are a couple of
other reasons you might want to consider using them…but I’m getting a bit
ahead of myself. The first thing I do when I’m researching a new anabolic is
to jump on the internet and do some research in all of the available medical
databases, and exhaust every search engine imaginable with keywords related to
the new compound. The next thing I do is typically to get a couple of vials and
try it for myself. I’m in a very unique position with regards to trying new
compounds; in the case of several compounds (Esterless Boldenone, Masteron
Enanthate, Stealth Injectables, etc…) I was actually able to try the products
before they were released to the general public. In the case of Hexarelin and
GHRP-6, I have had the opportunity to experiment with them for the past few
months.
When I first received my vials of GHRP-6 and Hexarelin, I did what most people
probably do…I reconstituted them, shot first, and asked questions later. I
thought it would be a great idea to fire up 600mcs of GHRP-6 just before a heavy
max effort deadlift session. Bad idea. I have a 45 minute drive to my gym (I
happen to workout at a military academy, where I coach), and halfway there, I
started to get a bit hungry. No problem, right? We’ve all worked out a bit
hungry…well, that’s what I thought at first. Then when I hit about 400lbs
into my deadlifts, I started getting dizzy…I broke into a cold sweat, and I
had to sit down. I rushed to get some simple carbs into my body as quickly as
possible, thinking that I was going hypoglycemic. Ok…I wasn’t going
hypoglycemic, but it was pretty bad. That workout was shot. Still, I was
wondering if I could actually slip into some kind of severe hypoglycemia from a
shot of GHRP-6…it certainly felt like I could.
So, naturally, I was interested, and did some experimenting. I waited a day and
invited a friend over to my place…then I did another shot of 600mcg (split
bilaterally, 300mcg into each leg, as a subcutaneous shot). Then we sat around
and waited, with a bunch of simple carbs ready. I got hungry, I was
uncomfortable, and it wasn’t too much fun, but we sat there for a good couple
of hours, and I didn’t pass out (in case you’re wondering, the friend was
there to drive me to the hospital, in case I actually did pass out). Ok…so
that settles that. Originally, I thought that maybe GHRP-6 operated by inducing
some kind of mild hypoglycemia (hypoglycemia increases GH output). But that’s
not how it actually works…
Growth Hormone Releasing Peptide- 6 (GHRP-6) is a synthetic hexapeptide which
stimulates the release of Growth Hormone. It accomplishes this by two totally
separate mechanisms. On the one hand, it amplifies your body’s natural Growth
Hormone Releasing Hormone (GHRH) signal transduction pathway, and on the other
hand, acts as a functional antagonist of the hormone which causes inhibition of
GH secretion (somatostatin) (1-3).
GHRP-6 also has the benefit of being able to directly stimulate the anterior
pituitary gland, resulting in increased GH release. So although my initial
thoughts on the mechanism of action for this stuff was wrong, I was enthused
when my research revealed that GHRP-6 induced GH secretion occurs by several
mechanisms. Most importantly, those mechanisms are the induction of GHRH release
from the hypothalamus, stimulation of GH release from somatotrophs, joint
actions of GHRH and antagonism of somatostatin, and finally by pronounced
antagonism of somatostatin action on somatotrophs (1-4). However, it bears
clarification that GHRP-6 is not dependant on the GHRH pathway…it can boost
your growth hormone levels without necessarily needing to elevate GHRH. This is
important because if that pathway has been inhibited by long term GH use, GHRP-6
can still get your body producing and releasing GH.
Additionally, this peptide can also act on the central nervous system, which can
provide added benefits in neuroprotection as well as muscular strength increases
for the user. Much of the strength increases we see with Anabolic Steroids in
the Dihydrotestosterone family are suspected to be through a similar stimulation
of the Central Nervous System. In my experience with GHRP-6 use, strength levels
typically go up within the first week of starting out.
Increases in Growth Hormone levels in the body are typically accompanied by
strength increases, muscle hypertrophy (growth), and lipolysis (fat loss). Other
results experienced with increased GH levels are recuperative effects on joints
and injuries; connective tissue strengthening and bone mineral density
improvements are commonplace. Enhanced GH secretion also leads to the liver
secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the
primary anabolic mechanism of action for Growth Hormone. In the case of GHRP-6,
I gained quite a bit of weight when I was running it at the 600mcg/day level. I
think that this was probably due to overfeeding that almost always accompanied
my shot contributed to this weight gain. I gained about 12lbs in 2 weeks. I
think that the same way people often throw EQ into bulking cycles to increase
appetite stimulation, I would suggest using GHRP-6 instead. It’s not anywhere
near as anabolic, but the appetite increase is far a!
bove anything I’ve ever experienced with any anabolics.
The women I know who have used GHRP-6 all had to discontinue its use because it
was making them gain weight too quickly. But then again, most of the women who I
know are national level (or professional) physique competitors, and at most need
an additional 5-10lbs of muscle at most. GHRP-6 just put too much weight on them
too quickly.
After experimenting with GHRP-6 for weight gain, I lowered the dose
substantially and used it to help rehab a knee injury that had been bothering me
for a couple of years. In this case, I lowered it to 100mcg/day, shot sub-q into
the knee (ouch!). At this dose you won’t find the extreme hunger that a high
dose of it usually causes, and a 5mg bottle of GHRP-6 is going to last for
months, and I’m confidant that it’s going to be enough to rehab virtually
any injury (in my case, I had done extensive damage to my knee over the years,
culminating in a traumatic injury playing on turf…which resulted in my
semi-retirement from competitive athletics). Anyway, I combined GHRP-6 with a
knee rehab protocol designed by Eric Cressey, M.A. C.S.C.S., and advice from one
of my research assistants, who has a degree in Sports Medicine. Taken this way,
I used GHRP-6, and rehabbed my knee to almost where it was prior to my beginning
my career in athletics. If you have an injury, find you!
rself a good rehab protocol, and try a low dose of GHRP-6. I bet you’ll be
surprised.
Oh…and this brings me to another point. I’m sure most people subscribe to
the theory that peptides only last for a couple of weeks in their reconstituted
form. Well, after I had my GHRP-6 reconstituted for well over a month, I tried a
shot at my old 600mcg dose, and guess what happened? Yeah, I got a huge increase
in appetite within the hour. This tells me that we’re really underestimating
the amount of time that a reconstituted peptide can retain its potency. I’m
betting we have months, not weeks.
Since GHRP-6 acts directly on the feedback loop which signals the inhibition of
GH release, it has been used immediately following either GH or IGF-1 cycles, to
recover natural GH production by inhibiting somatostatin action. It has also
been used concurrently with those compounds to negate some of the effects of
those compounds on natural GH production. Most people who use IGF never actually
realize that as IGF is part of the hormonal cascade that GH initiates, it is
also part of the Negative feedback loop for it.
Typical doses of GHRP-6 range from 100mcg/day injected subcutaneously (for
connective tissue strengthening) to 500mcg/day (for an anabolic effect). After
experimentation with a wide variety of doses, and input from several people who
have also used the product, I think that 500mcg/day is the upper limit of
effective dosing for GHRP-6.
The most rapid side effect experienced with GHRP-6 is extreme hunger, which
typically occurs within an hour of injection. This could be due to a possible
effect on blood sugar lowering, or more likely (I suspect) due to its influence
on Ghrelin (5), stimulated by the peptide influenced release of GH. Ghrelin, by
the way, increases appetite and speeds gastric emptying. This means…even if
you weren’t hungry a second ago, and your Ghrelin levels go up too
much…you’ll be starving soon.
If I were looking to figure out the best way to use GHRP-6 in a bulking cycle, I
would simply take my favorite bulking cycle, and run GHRP-6 with it at a daily
dose of 600mcg/day, shot post-workout. The reason for the post-workout dosing is
to take advantage of the appetite stimulating properties, at the same time as
taking maximum advantage of the anabolic properties of the GH release that it
will cause. And I’d probably consider using some insulin as well, because
insulin is highly anabolic on its own, but also because the GH response to
GHRP-6 is elevated with concurrent use of insulin (6). Again, this is only how
I’d do it personally, and I’m sure people will experiment with things and
find the optimal way to get the results they want on an individual basis. GHRP-6
and this is no exaggeration, will put as much weight on you as nearly any
steroid. If you’re not careful, you’ll gain too much fat…my recommendation
is to use this stuff on your off season bulking !
cycles.
Overall, I was pretty impressed with GHRP-6, in my experience with it. Its
ability to put weight on me was actually too potent, although the strength gains
were nice. Now, I’ll mostly use GHRP-6 for post cycle therapy from IGF use, or
when I need to get rid of an injury.
-GHRP-6 and Hexarelin
By Anthony Roberts
Earlier this year, I was interviewed by a major online bodybuilding site (the
interview was titled “Chemically Insane”), and in that interview, I
predicted that various peptides would become the newest trend in performance
enhancing drugs. For the most part, I was correct, and now they’re very
popular and widely available, although still relatively new.
So, several months ago, I began my experimentation with various peptides, mostly
with the goal of figuring out the best way to use them. My last major article
examined my experiences with the two most popular peptides (IGF and MGF)
currently on the market. This time around, I’m going to tell you about my
experience with Hexarelin and GHRP-6, two lesser known peptides. With Lr3IGF-1,
the use and goals of use is pretty straightforward…you pretty much use it to
gain muscle and lose fat; on rare occasions, people use it to rehab an injury (I
actually provided a full rehab protocol using IGF-1 in my first e-book). With
MGF, it’s even simpler…you use it to increase muscle size, period.
Using the other peptides is a bit more complicated, and there are a couple of
other reasons you might want to consider using them…but I’m getting a bit
ahead of myself. The first thing I do when I’m researching a new anabolic is
to jump on the internet and do some research in all of the available medical
databases, and exhaust every search engine imaginable with keywords related to
the new compound. The next thing I do is typically to get a couple of vials and
try it for myself. I’m in a very unique position with regards to trying new
compounds; in the case of several compounds (Esterless Boldenone, Masteron
Enanthate, Stealth Injectables, etc…) I was actually able to try the products
before they were released to the general public. In the case of Hexarelin and
GHRP-6, I have had the opportunity to experiment with them for the past few
months.
When I first received my vials of GHRP-6 and Hexarelin, I did what most people
probably do…I reconstituted them, shot first, and asked questions later. I
thought it would be a great idea to fire up 600mcs of GHRP-6 just before a heavy
max effort deadlift session. Bad idea. I have a 45 minute drive to my gym (I
happen to workout at a military academy, where I coach), and halfway there, I
started to get a bit hungry. No problem, right? We’ve all worked out a bit
hungry…well, that’s what I thought at first. Then when I hit about 400lbs
into my deadlifts, I started getting dizzy…I broke into a cold sweat, and I
had to sit down. I rushed to get some simple carbs into my body as quickly as
possible, thinking that I was going hypoglycemic. Ok…I wasn’t going
hypoglycemic, but it was pretty bad. That workout was shot. Still, I was
wondering if I could actually slip into some kind of severe hypoglycemia from a
shot of GHRP-6…it certainly felt like I could.
So, naturally, I was interested, and did some experimenting. I waited a day and
invited a friend over to my place…then I did another shot of 600mcg (split
bilaterally, 300mcg into each leg, as a subcutaneous shot). Then we sat around
and waited, with a bunch of simple carbs ready. I got hungry, I was
uncomfortable, and it wasn’t too much fun, but we sat there for a good couple
of hours, and I didn’t pass out (in case you’re wondering, the friend was
there to drive me to the hospital, in case I actually did pass out). Ok…so
that settles that. Originally, I thought that maybe GHRP-6 operated by inducing
some kind of mild hypoglycemia (hypoglycemia increases GH output). But that’s
not how it actually works…
Growth Hormone Releasing Peptide- 6 (GHRP-6) is a synthetic hexapeptide which
stimulates the release of Growth Hormone. It accomplishes this by two totally
separate mechanisms. On the one hand, it amplifies your body’s natural Growth
Hormone Releasing Hormone (GHRH) signal transduction pathway, and on the other
hand, acts as a functional antagonist of the hormone which causes inhibition of
GH secretion (somatostatin) (1-3).
GHRP-6 also has the benefit of being able to directly stimulate the anterior
pituitary gland, resulting in increased GH release. So although my initial
thoughts on the mechanism of action for this stuff was wrong, I was enthused
when my research revealed that GHRP-6 induced GH secretion occurs by several
mechanisms. Most importantly, those mechanisms are the induction of GHRH release
from the hypothalamus, stimulation of GH release from somatotrophs, joint
actions of GHRH and antagonism of somatostatin, and finally by pronounced
antagonism of somatostatin action on somatotrophs (1-4). However, it bears
clarification that GHRP-6 is not dependant on the GHRH pathway…it can boost
your growth hormone levels without necessarily needing to elevate GHRH. This is
important because if that pathway has been inhibited by long term GH use, GHRP-6
can still get your body producing and releasing GH.
Additionally, this peptide can also act on the central nervous system, which can
provide added benefits in neuroprotection as well as muscular strength increases
for the user. Much of the strength increases we see with Anabolic Steroids in
the Dihydrotestosterone family are suspected to be through a similar stimulation
of the Central Nervous System. In my experience with GHRP-6 use, strength levels
typically go up within the first week of starting out.
Increases in Growth Hormone levels in the body are typically accompanied by
strength increases, muscle hypertrophy (growth), and lipolysis (fat loss). Other
results experienced with increased GH levels are recuperative effects on joints
and injuries; connective tissue strengthening and bone mineral density
improvements are commonplace. Enhanced GH secretion also leads to the liver
secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the
primary anabolic mechanism of action for Growth Hormone. In the case of GHRP-6,
I gained quite a bit of weight when I was running it at the 600mcg/day level. I
think that this was probably due to overfeeding that almost always accompanied
my shot contributed to this weight gain. I gained about 12lbs in 2 weeks. I
think that the same way people often throw EQ into bulking cycles to increase
appetite stimulation, I would suggest using GHRP-6 instead. It’s not anywhere
near as anabolic, but the appetite increase is far a!
bove anything I’ve ever experienced with any anabolics.
The women I know who have used GHRP-6 all had to discontinue its use because it
was making them gain weight too quickly. But then again, most of the women who I
know are national level (or professional) physique competitors, and at most need
an additional 5-10lbs of muscle at most. GHRP-6 just put too much weight on them
too quickly.
After experimenting with GHRP-6 for weight gain, I lowered the dose
substantially and used it to help rehab a knee injury that had been bothering me
for a couple of years. In this case, I lowered it to 100mcg/day, shot sub-q into
the knee (ouch!). At this dose you won’t find the extreme hunger that a high
dose of it usually causes, and a 5mg bottle of GHRP-6 is going to last for
months, and I’m confidant that it’s going to be enough to rehab virtually
any injury (in my case, I had done extensive damage to my knee over the years,
culminating in a traumatic injury playing on turf…which resulted in my
semi-retirement from competitive athletics). Anyway, I combined GHRP-6 with a
knee rehab protocol designed by Eric Cressey, M.A. C.S.C.S., and advice from one
of my research assistants, who has a degree in Sports Medicine. Taken this way,
I used GHRP-6, and rehabbed my knee to almost where it was prior to my beginning
my career in athletics. If you have an injury, find you!
rself a good rehab protocol, and try a low dose of GHRP-6. I bet you’ll be
surprised.
Oh…and this brings me to another point. I’m sure most people subscribe to
the theory that peptides only last for a couple of weeks in their reconstituted
form. Well, after I had my GHRP-6 reconstituted for well over a month, I tried a
shot at my old 600mcg dose, and guess what happened? Yeah, I got a huge increase
in appetite within the hour. This tells me that we’re really underestimating
the amount of time that a reconstituted peptide can retain its potency. I’m
betting we have months, not weeks.
Since GHRP-6 acts directly on the feedback loop which signals the inhibition of
GH release, it has been used immediately following either GH or IGF-1 cycles, to
recover natural GH production by inhibiting somatostatin action. It has also
been used concurrently with those compounds to negate some of the effects of
those compounds on natural GH production. Most people who use IGF never actually
realize that as IGF is part of the hormonal cascade that GH initiates, it is
also part of the Negative feedback loop for it.
Typical doses of GHRP-6 range from 100mcg/day injected subcutaneously (for
connective tissue strengthening) to 500mcg/day (for an anabolic effect). After
experimentation with a wide variety of doses, and input from several people who
have also used the product, I think that 500mcg/day is the upper limit of
effective dosing for GHRP-6.
The most rapid side effect experienced with GHRP-6 is extreme hunger, which
typically occurs within an hour of injection. This could be due to a possible
effect on blood sugar lowering, or more likely (I suspect) due to its influence
on Ghrelin (5), stimulated by the peptide influenced release of GH. Ghrelin, by
the way, increases appetite and speeds gastric emptying. This means…even if
you weren’t hungry a second ago, and your Ghrelin levels go up too
much…you’ll be starving soon.
If I were looking to figure out the best way to use GHRP-6 in a bulking cycle, I
would simply take my favorite bulking cycle, and run GHRP-6 with it at a daily
dose of 600mcg/day, shot post-workout. The reason for the post-workout dosing is
to take advantage of the appetite stimulating properties, at the same time as
taking maximum advantage of the anabolic properties of the GH release that it
will cause. And I’d probably consider using some insulin as well, because
insulin is highly anabolic on its own, but also because the GH response to
GHRP-6 is elevated with concurrent use of insulin (6). Again, this is only how
I’d do it personally, and I’m sure people will experiment with things and
find the optimal way to get the results they want on an individual basis. GHRP-6
and this is no exaggeration, will put as much weight on you as nearly any
steroid. If you’re not careful, you’ll gain too much fat…my recommendation
is to use this stuff on your off season bulking !
cycles.
Overall, I was pretty impressed with GHRP-6, in my experience with it. Its
ability to put weight on me was actually too potent, although the strength gains
were nice. Now, I’ll mostly use GHRP-6 for post cycle therapy from IGF use, or
when I need to get rid of an injury.