ALCAR in rats

[Moyer]

Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats.

J Nutr. 2002 Apr;132(4):636-42
Iossa S, Mollica MP, Lionetti L, Crescenzo R, Botta M, Barletta A, Liverini G.
Department of General and Environmental Physiology, University of Naples Federico II, Italy I-80134.

Variations in energy balance, body composition, and nutrient partitioning induced by acetyl-L-carnitine (ALCAR) supplementation were studied in young (2 mo) and old (24 mo) Wistar rats. Changes in skeletal muscle metabolism as well as in serum free triiodothyronine and leptin levels were also evaluated. Rats were administered 0 (control) or 15 g/L ALCAR in their drinking water for 1 mo. ALCAR treatment significantly decreased body lipid percentage in young rats and significantly increased body protein percentage in old rats. The percentage of metabolizable energy (ME) intake stored as lipid was lower in ALCAR-treated young rats, whereas the percentage of ME intake stored as protein was greater in ALCAR-treated old rats compared with their age-matched controls. In addition, ALCAR supplementation significantly decreased serum leptin levels in old rats. Elevated skeletal muscle respiration was found in old rats treated with ALCAR, due to an increase in mitochondrial protein mass. In conclusion, ALCAR supplementation decreases efficiency of lipid deposition in young rats and increases efficiency of protein deposition in old rats. In addition, ALCAR supplementation partly reduces the leptin resistance that occurs in old rats, and improves ATP production in skeletal muscle mitochondria through an increase in mitochondrial protein content.

PMID: 11925454

 

[3clipseGT]

Laymens terms please? :wtf: :lol:

Im takin a stab at it and hopin it means that it decreases fat and helps build muscle?

 

[John Smeton]

any other studies?

ive been taking alcar since Nov 05. 3 grams everyday . does that article say they put 15 grams in the rats water?

does that mean to really work really good i need to up my dose to 6-10 grams a day? cause ill do it if it works . ill do whatever it takes(on my terms) to get my sixpack!~

 

[TheCrownedOne]

The abstract doesn't note how much of the 15g/L water the rats drank. And, again, we're not rats, otherwise my sodium tungstate experiment would've put me at 3% bf. In the most convenient (and germane to our aim) terms, the abstract relays that the rats increased their body protein and decreased their body fat.