Ephedra-free Lipo-6x stacker causes heart attack

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    Ephedra-free Lipo-6x stacker causes heart attack


    Ephedra-free Lipo-6x stacker causes heart attack

    After the American government outlawed ephedra slimming supplements as a result of hundreds of fatalities, the supplements industry introduced ephedra-free stackers. Perhaps not as effective as the outlawed ephedrine-based stackers, these alternatives were safer. Unfortunately ‘safer’ doesn’t mean ‘completely safe’. Cardiologists at the American Walter Reed Army Medical Center have reported a case of an almost fatal heart attack, which was probably caused by the ephedra-free stacker Lipo-6x.

    Lipo-6x, manufactured by Nutrex Research, contains no ephedrine, the active ingredient in the forbidden Ephedra sinica extracts. According to the label, Lipo-6x contains substances related to ephedrine such as synephrine [structure on the right], beta-phenylethylamine, n-methyl-beta-phenylethylamine, tyramine and hordenine. These substances are found in extracts of the legal Citrus aurantium and Acacia rigidula, and they imitate the effect of adrenalin. In addition, Lipo-6x contains caffeine, a stimulatory compound that makes cells more sensitive to adrenalin. It also contains yohimbine and guggulsterones.


    The article that the cardiologists published in the Texas Heart Institute Journal describes a 24-year-old man who collapsed at work with chest pain and breathing difficulties. The man had done a 2-hour weight and cardio training session that morning.

    The man was a picture of health: not overweight, no diabetes, no high blood pressure, healthy blood values, non-smoker, did not use steroids, drugs or alcohol, had no family history of heart problems. And he was in peak condition: he trained five times a week.

    The only risk factor the doctors could find was that the guy took Lipo-6x just before training, twice a week. His dose was 1 capsule. And he’d a capsule the morning he had a heart attack. When the doctors examined pictures of the blood vessels in the man’s heart muscle, they saw that an important blood vessel was no longer working. The picture below shows a blood clot that was partially blocking the proximal left anterior descending coronary artery[*]. The distal left anterior descending coronary artery was completely blocked [#]

    The doctors did microsurgery to try and clear the blood vessels. They were partially successful, as the photo below shows. The blood clot in the proximal left anterior descending coronary artery disappeared[*], but the distal left anterior descending coronary artery remained blocked [#].

    The doctors put the man on aspirin, beta-blockers, statins and ACE-inhibitors. He recovered and was discharged from hospital.

    The researchers believe that it was the supplement that caused the man to have a heart attack. Lipo-6x doesn’t contain ephedrine, but ephedra-free stackers are not without health risks. "Our case highlights the potential health hazards associated with supplements that contain sympathomimetic compounds similar to ephedra", the cardiologists conclude. "In light of these facts, as well as the empiric risk of synergism in the above-mentioned agents, we believe that performance enhancement use was the precipitant of this patient’s cardiac event, and we believe that greater FDA involvement in the regulation of such supplements is warranted".

    Source:
    Tex Heart Inst J. 2009;36(6):586-90.

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    ...... it wouldnt have caused a blood clot... this is a bull**** case to stir up hysteria
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    the medical industry is falling all over themselves to knock out the supplement industry. There are no doctor kickbacks, free trips, etc in it for them.

    This should come as no surprise, and knowing the level of stupid corruption in this country, it will likely succeed.
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    ^^^ YUP, remember good bros, pharms GIVE docs money to support their meds, so when someone goes hey doc, can I use fish oil, they say well I suggest LOVAZA, its better. Its all about the green bill...
    doing my own thang!
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    i hate how docs and the fda go hand in hand with this sh**. really? a stimulant caused blood clots? i personally dont believe it unless you have some significant proof of this doc. and it is true, just as andrew732 said, "so when someone goes hey doc, can I use fish oil, they say well I suggest LOVAZA, its better. Its all about the green bill...". it is about money now-a-days. why cant the fda leave us alone? and doctors for that matter?

    i would be willing to bet anyone that if i asked my doctor to replace each supp i took, which he said to not take (due to his lack of knowledge on a particular ingredient), he would either prescribe me, or refer me to a different medication that's otc, and tell me to use it instead. hell, he even told me not to take my pre-wo powder, but allowed my post cycle tabs only because they had milk thistle in them... i wasn't surprised. i was just amazed that he was pretty naive about it all.

    i've had doctors research things for me in the past, lettign me know if it was ok to take, etc. but he just didnt seem to give a sh**. think i should talk to a sport med. specialist?
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    Quote Originally Posted by andrew732 View Post
    ^^^ YUP, remember good bros, pharms GIVE docs money to support their meds, so when someone goes hey doc, can I use fish oil, they say well I suggest LOVAZA, its better. Its all about the green bill...
    Ohh too true.
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    Quote Originally Posted by dsade View Post
    the medical industry is falling all over themselves to knock out the supplement industry. There are no doctor kickbacks, free trips, etc in it for them.

    This should come as no surprise, and knowing the level of stupid corruption in this country, it will likely succeed.
    Unfortunately there is some clueless people who fall for the scare tactics created by media, govt. etc. but there is also a growing number of people who are begginning to smarten up.
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    ok firstly the cath images blow. they couldn't do a selective injection for better clarity? too much overlap. they also dont show a RCA injection. If the patient is RCA dominant, this vessel supplies the left vent apex, not the LAD. So this "blocked" LAD could be its normal non-dominant course.
    also that's a huge freaking clot. but surprisingly there is pretty good flow beyond it. i'm not saying that clot is a photoshop, but the flow beyond the clot is too good. also, if you take out the LAD and D1 on a 27 year old with no collaterals, he should be dead.
    So although this "clot" looks real, it doesnt add up at all. Could be a shop, could be flow artifact, could be real but it wouldnt be from the Lipo6. I sure hope they tested him for paradoxical emboli and clotting disorders. In fact he could have been so dehydrated after the workout that that alone caused the thrombus.
    so yeah, busted. total hysteria.
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    The only risk factor the doctors could find was that the guy took Lipo-6x just before training, twice a week. His dose was 1 capsule.
    Wow..1 cap twice a week??

    I doubt the product did anything for him, if the article said 6 caps 5 days a week we could have a case of maybe overdosing...but come on...1 cap would cause a blood clot, kinda hard to believe..
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    But the again...it comes from a credible source...
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    I call bull**** on this. No way that would cause a blood clot. He already had a problem that was not previously discovered and they are just trying to blame it on a supplement. My brother started having tachycardia and heart pain a year or so ago and at first they tried telling him its cause he drank energy drinks or too much soda. Then after some extensive testing they said it was all due to an abnormality with his AV node. I do not see how a stimulant will cause blood to clot.
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    Quote Originally Posted by Mjolnir View Post
    I call bull**** on this. No way that would cause a blood clot. He already had a problem that was not previously discovered and they are just trying to blame it on a supplement. My brother started having tachycardia and heart pain a year or so ago and at first they tried telling him its cause he drank energy drinks or too much soda. Then after some extensive testing they said it was all due to an abnormality with his AV node. I do not see how a stimulant will cause blood to clot.
    stimulants shouldn't cause a blood clot, unless they have something in them to make the blood clot easier... which isn't the case any any stims/fat burners i know of. this just seems to me like the fda and another doctor trying to keep people away from our industry... oh well, what can we do other than talk about it on our little forums?

    i know AM isn't little, but you get my point haha
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    I just saw on TV the other day 77,000 people a year are hospitalized in the US due to aspirin. Another 7,600 die.

    Where's the outrage?

    It's actually considered a safe drug!
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    I could see a yohimbine containing product causine a problem in someone who was already pushing themselves to the limit. Not the average person limit, but a real limit. having said that, it wouldn't cause a blood clot.
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    Quote Originally Posted by bigrobbierob View Post
    I just saw on TV the other day 77,000 people a year are hospitalized in the US due to aspirin. Another 7,600 die.

    Where's the outrage?

    It's actually considered a safe drug!
    Most pharmacists will admit that aspirin wouldn't pass the safety regulations if it were introduced today.

    I agree with what you said urbanski, would love more images. But perhaps it's just a weird non-occlusive thrombus since there's good flow as you pointed out, otherwise a LAD block w/out collaterals def would have killed him. I have faith the interventionist checked R vs L dominance, it's pretty standard.

    Kingdon the symptoms came on 30mins PostWO, so it wasn't about pushing himself to the limit.
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    Quote Originally Posted by Steveoph View Post
    Most pharmacists will admit that aspirin wouldn't pass the safety regulations if it were introduced today.

    I agree with what you said urbanski, would love more images. But perhaps it's just a weird non-occlusive thrombus since there's good flow as you pointed out, otherwise a LAD block w/out collaterals def would have killed him. I have faith the interventionist checked R vs L dominance, it's pretty standard.

    Kingdon the symptoms came on 30mins PostWO, so it wasn't about pushing himself to the limit.
    Fair enough. And I did say that it wouldn't cause a blood clot anyway.
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    Amazin discussion , seems that we have experts on the board...
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    Quote Originally Posted by nynone View Post
    i hate how docs and the fda go hand in hand with this sh**. really? a stimulant caused blood clots?
    Stimulants can certainly cause blood clotting, especially those with high affinity for alpha receptors (i.e. synephrine).

    Agonising alpha-2 receptors on platelets cause platelet-activation and subsequent clotting. They also increase BP (alpha1-receptor agonism), especially during exercise, which can result in apical akinesis. The presence of yohimbine will exacerbate this condition.
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