[bbmg33]

Has anyone out there heard of this new drug or know anything about it? There isn't much info on the web about it. I saw an article in the LA Times about it and wanted some more info...Any assistance would be appreciated!

-Kristina

[JohnnieFreeze]

Ive read that same article....."Researchers experiment with a chemical compound that they say can produce the benefits of aerobic activity without the work."

Link to the article...sounds like at least a piece of that "magic pill"

http://www.latimes.com/features/heal...,4249687.story

[WilteredFire]

L-Carnitine Supplementation: A New Paradigm for its Role in Exercise

William J. Kraemer , Jeff S. Volek, Barry A. Spiering, and Jakob L. Vingren

Human Performance Laboratory, Department of Kinesiology, Department of Physiology
and Neurobiology, University of Connecticut, Storrs, CT USA 06269

Received October 20, 2004; accepted November 24, 2004
Published online June 10, 2005 Springer-Verlag 2005

Summary. Early research investigating the effects of L-carnitine supplementation has examined its role in substrate metabolism and in acute exercise performance. These studies have yielded equivocal findings, partially due to difficulties in increasing muscle carnitine concentrations. However, recent studies have proposed that L-carnitine may play a different role in exercise physiology, and preliminary results have been encouraging. Current investigations have theorized that L-carnitine supplementation facilitates exercise recovery. Proposed mechanism is as follows: 1) increased serum carnitine concen-tration enhances capillary endothelial function; 2) increased blood flow and reduced hypoxia mitigate the cascade of ensuing, destructive chemical events following exercise; 3) thus allowing reduced structural damage of skeletal muscle mediated by more intact receptors in muscle needed for improved protein signaling. This paradigm explains decreased markers of purine catabolism, free radical forma-tion, and muscle tissue disruption after resistance exercise and the increased repair of muscle proteins following long-term L-carnitine supplementation.

======

Try pull up some info and research on the new version of Alcar called PLCAR, this is where the Carnitine limelight is focused on right now i reckon, Alcar basically is used for more focus, energy in the gym, to enhance mood (yes you can generally feel a more happy feeling after a small dose of Alcar, i can feel it after 150-200mg's with water), the other area of interest in this substance seems to be fatloss, and its apparant abilitys in getting your body to use fat as fuel for enegy, and if i remember correctly, the PLCAR and Alcar seems to have the ability to refresh/create AR's, good for people who want to take steroids/ph's and get as good gains as they do with their first cycle.

Please somebody correct me if im wrong, this is just what I know about Alcar. People who have been injecting Alcar have been reporting promising results for fatloss. PLCAR looks more promising though

[sportsterdann]

Aicar not Alcar..

[mtlbob]

Originally Posted by bbmg33

Has anyone out there heard of this new drug or know anything about it? There isn't much info on the web about it. I saw an article in the LA Times about it and wanted some more info...Any assistance would be appreciated!

-Kristina

This is the original article about AICAR. Can't wait to get it!!!

CELL
Volume 134, Issue 3, 8 August 2008, Pages 405-415
doi:10.1016/j.cell.2008.06.051

AMPK and PPARδ Agonists Are Exercise Mimetics

Vihang A. Narkar1, Michael Downes1, Ruth T. Yu1, Emi Embler1, Yong-Xu Wang4, Ester Banayo3, Maria M. Mihaylova2, Michael C. Nelson1, Yuhua Zou1, Henry Juguilon1, Heonjoong Kang5, Reuben J. Shaw2 and Ronald M. Evans1, 3, ,

1Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA 2Molecular and Cell Biology Laboratory, Salk Institute, La Jolla, CA 92037, USA 3Howard Hughes Medical Institute, La Jolla, CA 92037, USA 4University of Massachusetts Medical School, Worcester, MA 01605, USA 5Marine Biotechnology Laboratory, School of Earth and Environmental Sciences, Seoul National University, Seoul 151-747, South Korea

Received 30 May 2007; revised 23 April 2008; accepted 20 June 2008. Published online: July 31, 2008. Available online 31 July 2008.

Can Exercise Mimetics Substitute for Exercise?

Cell Metabolism, Volume 8, Issue 2, 6 August 2008, Pages 96-98
Erik A. Richter, Bente Kiens, Jørgen F.P. Wojtaszewski
PDF (202 K)

Summary

The benefits of endurance exercise on general health make it desirable to identify orally active agents that would mimic or potentiate the effects of exercise to treat metabolic diseases. Although certain natural compounds, such as reseveratrol, have endurance-enhancing activities, their exact metabolic targets remain elusive. We therefore tested the effect of pathway-specific drugs on endurance capacities of mice in a treadmill running test.

We found that PPARβ/δ agonist and exercise training synergistically increase oxidative myofibers and running endurance in adult mice. Because training activates AMPK and PGC1α, we then tested whether the orally active AMPK agonist AICAR might be sufficient to overcome the exercise requirement. Unexpectedly, even in sedentary mice, 4 weeks of AICAR treatment alone induced metabolic genes and enhanced running endurance by 44%. These results demonstrate that AMPK-PPARδ pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise.

Author Keywords: SIGNALING