- 08-27-2011, 02:09 PM
- 09-10-2011, 12:51 PM
- 09-25-2011, 07:16 AM
09-28-2011, 04:32 AM
Preliminary Study of the Vasorelaxant Effects of (+)-Nantenine, an Alkaloid Isolated from Platycapnos spicata, in Rat Aorta
Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
In this work, the potential vasorelaxant activity of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, was studied for the first time in rat aorta. (+)-Nantenine (3 - 30 μM) totally relaxed, in a concentration-dependent manner and with almost equal effectiveness, the contractions induced by noradrenaline (NA) or by a high KCl concentration (60 mM) in intact rat aortic rings. Mechanical removal of endothelium and/or pretreatment of aorta rings with glibenclamide (10 μM) or tetraethylammonium (TEA, 2 mM) did not significantly modify the vasorelaxant effects of this aporphine alkaloid. In the experiments in Ca2+-free medium, (+)-nantenine (10 μM) had no effect on caffeine-induced contractions. Furthermore, in the studies with radiolabelled Ca2+, (+)-nantenine (3 - 30 μM) did not modify the basal uptake of 45Ca2+ but decreased, in a concentration-dependent fashion, the influx of 45Ca2+ induced by NA and KCl in endothelium-containing and endothelium-denuded rat aortic rings. In addition, (+)-nantenine (3 - 30 μM) was ineffective to scavenge superoxide anion (O2-) radicals generated by the hypoxanthine (HX)-xanthine oxidase (XO) system and/or to inhibit XO activity. These results indicate that: a) the vasorelaxant effects of (+)-nantenine in rat aorta are due, at least in part, to a blockage of Ca2+ influx through transmembrane calcium channels, b) the activation of ATP-sensitive K+ channels (KATP) and large conductance Ca2+-activated K+ channels (KCa) present in smooth muscle cells, the presence (integrity) of endothelial system, an inhibitory action on XO enzymatic activity and/or O2- radicals scavenging properties are not involved in the vascular effects of (+)-nantenine in rat aorta described above. Just an interesting article I came across Thought a show about this compound or similar compounds might make a good show
09-29-2011, 08:46 PM
10-11-2011, 08:00 PM
I've been training my girlfriend more and more, and I liked the show you had with Alicia Fong on womens training strategies.
I would love to hear more from pro bikini chicks, or pro fitness girls, and learn more about their training first-hand.
Also, you used to have Matt Cahill as the supplement guru a while back. Now he's with DS sports, and there was that independent study on activate xtreme:
Clin Chim Acta. 2011 Oct 9;412(21-22):1999-2001. Epub 2011 Jul 12.
A novel case of a raised testosterone and LH in a young man.
McDonald TJ, Perry MH, Jones AG, Donohoe M, Salzmann MB, O'Connor J.
Clinical Chemistry, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
A 19 year old male attended his GP with a history of "fluid retention", lack of libido and erectile dysfunction. He was found to have a high serum testosterone, and a raised luteinising hormone. After further investigations, the patient admitted to taking a supplement called ActivaTe Xtreme, obtained from an internet source, to address his low libido. ActivaTe Xtreme contains active ingredients which increase serum testosterone levels by several independent mechanisms that are not associated with luteinising hormone suppression. Urine analyses for synthetic anabolic steroids were negative, and urinary testosterone, epitestosterone and other androgens were normal. This biochemical pattern is not the same as that seen with anabolic steroids (i.e. raised testosterone, suppressed luteinising hormone and abnormal urine steroid profile). The issue of self medication with performance enhancing compounds needs to be carefully considered in order to avoid expensive and invasive investigations, missing an underlying pathology or misdiagnosing a patient. This case also raises the spectre of yet another "performance enhancing" product that may cause difficulty for those trying to ensure that sport remains on a "hormonally" equal basis.
Copyright © 2011. Published by Elsevier B.V.
[PubMed - in process]
Also they're finally getting around to releasing their new preworkout, which has been in the works for at least a year. I think it would be great to have him on.
I'd like to know more about the 'latest & greatest' supplements hitting the market (like ursolic acid from PA). Let's hear what's new and what's hot, that kinda stuff.
11-22-2011, 10:32 AM
Hey Carl, I mentioned it on your Facebook page, but I think eating Paleo and working out on a budget would be a great idea for a show. Also supplements on a budget
11-24-2011, 12:47 AM
12-16-2011, 08:07 AM
James Levine from the Mayo Clinic
Important researcher in the new field of inactivity studies. They can studied the effects of sitting and it ain't good.
12-30-2011, 08:21 AM
hello carl.. i would very very interested on a show about bodybuilders adn non alchocholic fatty liver...i was resently diagnosed with this condition
though i m far from fat ( prety lean actually) and leading the bodybuilding lifestyle with ntrition and exercise..i have used AAS fpor the past 3 years moderately though..my hypatologist doesnt give an extract answer for what might caused this..he gave e the green light to eat as much protein as i want but keep an eye on sugars and oo many carbs.keeping my healthy fats high..
so a show about this condition . nutrition whith this condition? what macros? and what about AAS? what compounds would be safe to use and how much? in what duration? what about ancilaries?
12-30-2011, 08:26 AM
also carl to continue the previous message...what OTC SUPS CAN i safely consume? what can i take to keep my liver healthy while on this condition? and is there something i can do to reverce this condition? as far as exercise nutrition supplement oe else?
01-24-2012, 07:48 AM
01-24-2012, 07:50 AM
01-26-2012, 04:27 AM
I know most people here are not fans of soy, and I am not either, with the exception of soy lecithin. There are gmo free soy lecithins available, for those who are interested.
02-13-2012, 03:35 AM
Hey Carl! I would like a show that covers the benefits and negatives of cooking food. Which foods must be cooked and which are better raw. Thanks!
02-13-2012, 03:37 AM
02-13-2012, 04:03 AM
Another with Matt LeLonde and Robb wolf on actual eating for different people and goals. Say 18-25 male and female etc and so forth as well as goals like body comp and performance.
People still Wonder how to fuel for fat loss also
...:::Olympus Labs Rep:::...Crossfit - DEMIGOD -
02-15-2012, 01:14 PM
Should you train when you've got a cold (or any other illness)? The idea came to me in the obvious way* found this Mike Mahler article on tnation titled sick_go_train (can't post URL, sorry), and went training with a head cold. So-so session, but I was glad it was not Legs day! what do you think?
* note to self: always carry some vit. C in the car! when used immediately on the first hint, it usually averts the cold.
02-16-2012, 01:34 PM
How's it going Carl, hope all is well! I listened for the first time back when you had Rick Green of Celldyne on and were discussing Folstaxan.(if I'm not mistaken) You have an excellent program, just wanted to offer my thanks for all the GREAT info! Keep up the good work!
02-22-2012, 02:03 PM
02-22-2012, 02:13 PM
An episode is replaying right now with Dr. John McCarty and I would love to hear an updated show about spirulina. There are a lot of green powder supplements with this stuff out there, and I wonder about their efficacy.
03-07-2012, 12:28 PM
04-02-2012, 04:18 AM
04-02-2012, 04:33 AM
Already been...check archives...#487Originally Posted by PrimiFit
...:::Olympus Labs Rep:::...Crossfit - DEMIGOD -
04-10-2012, 12:48 AM
06-01-2012, 07:48 AM
06-01-2012, 08:40 PM
08-29-2012, 12:38 PM
Carl has likely already plowed this ground- but a show spent on HRT for newbies (men entering their 40's- not necessarily new to anabolics/hgh). Carl has a lot of good insight to add on this topic.
09-01-2012, 08:52 PM
Not sure if you've heard of this from Stanford University News ..
Stanford researchers' cooling glove 'better than steroids' – and helps solve physiological mystery, too
The temperature-regulation research of Stanford biologists H. Craig Heller and Dennis Grahn has led to a device that rapidly cools body temperature, greatly improves exercise recovery, and could help explain why muscles get tired.
It's on the stanford.edu website under news. Cannot post link here because of having too few posts.
It'd be interesting if you could get the researcher(s) on the show to discuss this further.
09-18-2012, 09:11 AM
This article is infuriating. Paleo blogger censored. Maybe give him some air time...
beaufortcountynow.com/post/4728/paleo-diet-blogger-expects-to-lose-first-round-of-free-speech-lawsuit dot HTML
09-19-2012, 05:50 AM
10-08-2012, 05:40 AM
Does anyone else have trouble hearing Adel Moussa, at least sometimes? Carl, can you please consider summarizing his recent statements more frequently? I know this is difficult because his thoughts are complex.This would be especially helpful for me when he discusses multiple physiological compounds (like adiponectin).
Also, about melatonin (above post): I imagine there's some newer research you could discuss in a future podcast.
10-11-2012, 10:44 PM
Cogrick2 I can hear him in as much as the audio quality is not being bad but he does cover a lot of material quickly. I am certainly a little lost at times on following everything in its fullest detail. I also appreciate that it is not dumbed down as it forces me to step up my knowledge. I read Adel's material on Suppversity too. I tend to listed to that stuff more than once.
I know Carl is downloading articles and maybe as part of this an Adel Summary of sorts could be part of it...
Easy for me to create more work for someone else
10-19-2012, 03:21 PM
Perhaps a show about the importance of shoulder and hip health. Injury prevention, rehabilitation and exercise discussions
10-22-2012, 09:07 AM
There is one talking about shoulder health. I heard it the other day listening to older shows. Pretty good show but I am not sure the name. Maybe search shoulder to find it.
10-23-2012, 08:56 PM
I feel like Rob Regish and Wade Johnson have talked about shoulder health but I have no idea which episode.
11-14-2012, 06:09 AM
I think that a show about internet addiction, more specifically porn addiction, would make for a fascinating topic. I just watched a TED presentation and it has shed allot of light on my own behavior. Having been a consumer for the last decade I see many, if not all, of the issues associated with this addiction present in my own life. I believe more information would not only be enlightening for myself but many other listeners as well.
11-14-2012, 11:07 AM
It might be interesting to have a roundtable discussion on bulking/cutting cycles vs. "lean bulking" throughout a year, highlighting the differences in results (lets say "on-stage" results) between a relaxed or aggressive bulk compared to a "lean bulk," and how to decide which one to employ - more importantly, whether the bulk and cut phases is not appropriate for a natty bodybuilder OR whether it actually is not just appropriate but superior to lean bulking. May have already been done - just throwing this idea out there.
Check your form: http://anabolicminds.com/forum/exercise-science/190675-proper-techniques.html
11-15-2012, 02:01 PM
I'd like to hear a show about prehab exercises and how to implement them to a strength training program.
01-13-2013, 09:52 PM
I would like a show on statins (pros and cons). alternative treatments for cholesterol control, and COQ10 supplementation (w/ statins).
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