M1T... A part I never quite understood..

[Fuego]

Lately I've been reading abit about M1-Test. And as always some people say it's the bomb and some say it's crap. But looking at the contents of Pacific Coast's M1T, it says: 17aa-1-testosterone (Methyl-1-Testosterone).

So basicly it is the same as 1-testosterone/dihydro-boldenone, only with the 17aa, hence methylated. Then I suppose the significant difference is that M1T is highly heptatoxic compared to 1-test. I've heard alot of people saying that M1T has got serious libido issues and causes shutdowns, but then how come 1-Test or 1-AD rarely or hardly ever has those issues? I mean, if that 17aa is the only difference?

This might be a dumb-ass question, but I guess it gives you educated people the chance to pass on some of that knowledge.. :think:

 

[ReaperX]

Lately I've been reading abit about M1-Test. And as always some people say it's the bomb and some say it's crap. But looking at the contents of Pacific Coast's M1T, it says: 17aa-1-testosterone (Methyl-1-Testosterone).

So basicly it is the same as 1-testosterone/dihydro-boldenone, only with the 17aa, hence methylated. Then I suppose the significant difference is that M1T is highly heptatoxic compared to 1-test. I've heard alot of people saying that M1T has got serious libido issues and causes shutdowns, but then how come 1-Test or 1-AD rarely or hardly ever has those issues? I mean, if that 17aa is the only difference?

This might be a dumb-ass question, but I guess it gives you educated people the chance to pass on some of that knowledge.. :think:

Who said that 1-test or 1-AD rarely caused shutdown ?

 

[Fuego]

People that've used 1-AD before. And a couple of other forums. Sounds like I've been fed wrong info here. I did try 1-AD sometime back at 300mg for 2-3 weeks and didn't experience anything wrong. Didn't go to the doctor to get checked though as I wasn't alarmed enough.

 

[ReaperX]

This is not just with M1T, but with methylated substances in general. With 17-alpha alkylated steroids, the conversion from a 17-hydroxy to a 17-keto steroid is prevented. The main difference between 17-aa's and regular steroids is that one retains a free 17 hydroxyl group and one does not, when going through the liver. The reason that 17-aa are toxic is because the free hydroxyl is able to be conjugated with glucuronic acid, forming a D ring 17-glucuronide. It is not the 17-aa steroid that is liver toxic but rather its 17-glucuronide metabolite. So it's not that these steroids are harder to metabolize, but rather the way they are metabolized causes them to be toxic.

 

[RBKing]

the methylation dramatically increases the potency and side effects of 1-test. Unmethylated drugs like epitiostanol and
THP stanazol are much less potent than Epistane and
Winstrol.

 

[RBKing]

This is not just with M1T, but with methylated substances in general. With 17-alpha alkylated steroids, the conversion from a 17-hydroxy to a 17-keto steroid is prevented. The main difference between 17-aa's and regular steroids is that one retains a free 17 hydroxyl group and one does not, when going through the liver. The reason that 17-aa are toxic is because the free hydroxyl is able to be conjugated with glucuronic acid, forming a D ring 17-glucuronide. It is not the 17-aa steroid that is liver toxic but rather its 17-glucuronide metabolite. So it's not that these steroids are harder to metabolize, but rather the way they are metabolized causes them to be toxic.

good post. The a/a potency of the metabolite in question also effects how toxic it is to the liver. M1T>Epi. PA is one
of the experts in this field.

 

[dice404]

I think a good example of how 17aa can effect a steroid would be to look at boldenone and dianabol. The only difference between these two steroids is that dianabol is 17-alpha alkylated, yet the effects of these two steroids are vastly different.

 

[ReaperX]

Well, yeah molecular structures can greatly change the properties and chemical itself.

I think he was after the toxicity effects.

 

[ReaperX]

17-glucuronides (metabolites) are to blame for liver toxicity.

Bile salt independent flow->glutathione+bicarbonates