It's hard to say.I'm not a fan of the ph combos myself.If you get sides you don't know which one is causing them.I like the idea of starting one compound low and increasing if needed.If you get sides you put up with them and don't increase any more or if the sides are to harsh,you bump it back down.Have you ran these compounds before?Liver wise the combos are much worse,they have 2 or 3 methyls in them,in this case 3.It seems to be how the new companies are going,but i'm not a follower.CEL and havoc and epistane all the way.One compound,one time.