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grapefruit and absorption?

LiftnIron00

New member
ive heard about people taking their pro-hormone/pro-steroids with grapefruit juice, i think it was, and i wanted to know is it supposed to increase absorption?
 
yes tons of info out there on this, look up on google, grapefruit, enzyme

its the p450 enzym that typically will oxidate most supps and this (grapefruit juice) is a powerfull anti oxident, basically it will not only increase the amount that will make it through on first pass but it will increase its longevity in the body if you drink alot.... plus it just tastes good.
 
poopypants said:
yes tons of info out there on this, look up on google, grapefruit, enzyme

its the p450 enzym that typically will oxidate most supps and this (grapefruit juice) is a powerfull anti oxident, basically it will not only increase the amount that will make it through on first pass but it will increase its longevity in the body if you drink alot.... plus it just tastes good.
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does it just work for methylated compounds or others like creatine?
 
creatine i belive is methylated..... dont quote me on it though.

either way it will basically increase absorbtion of most anything thats easily oxidized in the liver. methylation has nothin to do with it.
 
it doesn't affect the absorption rather the break down of the compound in the liver as you said in your first post, it breaks down the cytochrome p-450 enzyme so the original compound is in your body for longer and not broken down by the liver...
or did you mean that creatine will increase absorption by the body
 
also what about blood work? my dad used to eat grapefruits all the time and when he had his blood work done it would be messed up and he thinks its from the grapefuit. can it do this?
 
The interaction is not in the liver but the intestines. What happens is that the grapefruit juice inhibits cyp-450 which would normally metabolize the chemical in the intestines subsequently increasing bioavailability.
 
is it true that the narigen in rpm will have the same effect? furazadrol is expensive and anything i can do to decrease dosage i will do. got rpm on the way, should get it tomorrow. at 4-5 pills ed, cost of furazadrol is eating up my supps allowance.
 
Haltera said:
Ok, grapefruit juice increases absortion, but what about toxicity of methylated steroids???
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there would be no reason for you to take GFJ with a 17aa steroid--the idea is to take it with non 17aa to stop the liver from breaking it down---and if are doing 17aa and GFJ your just doing extra damage to your liver---------------------Does anyone know how much GFJ your supposed to take and that DHB product still around-- its the nargin concentrate right?
 
skull said:
there would be no reason for you to take GFJ with a 17aa steroid--the idea is to take it with non 17aa to stop the liver from breaking it down---and if are doing 17aa and GFJ your just doing extra damage to your liver---------------------Does anyone know how much GFJ your supposed to take and that DHB product still around-- its the nargin concentrate right?
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I'll repeat, it is not about the liver. It's about the intestinal wall. It will increase the absorption by decreasing metabolism of drugs that are metabolized by cyp-450 3a4 isoenzymes in intestinal wall. Only small amounts are needed and the effect can last up to 72 hours.
 
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jonny21 said:
I'll repeat, it is not about the liver. It's about the intestinal wall. It will increase the absorption by decreasing metabolism of drugs that are metabolized by cyp-450 3a4 isoenzymes in intestinal wall. Only small amounts are needed and the effect can last up to 72 hours.
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So are you saying it's not about the liver but the intestinal wall?? I don't get it, is that what you are saying multiple times in this thread? Am I right? So A) not about liver B) All about intestines? Is that right?? :thumbsup:

Invalid Link Removed
 
thebigt said:
is it true that the narigen in rpm will have the same effect? furazadrol is expensive and anything i can do to decrease dosage i will do. got rpm on the way, should get it tomorrow. at 4-5 pills ed, cost of furazadrol is eating up my supps allowance.
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its been said that narigen is the active in grapefruit juice, is this true? will taking rpm positively effect dosing of furazadrol, which is a non methl?
 
thebigt said:
its been said that narigen is the active in grapefruit juice, is this true? will taking rpm positively effect dosing of furazadrol, which is a non methl?
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Naringine is one of the flavinoids in grapefruit juice thought to inhibit cyp-450 3A4. Depends on what enzymes metabolize furazadrol. If one of them is cyp-450 then it will increase bioavailability.
 
X2 great post Jonny21! Reps when I can give em!:D
 
jonny21 said:
Well slick, it seems that most that have posted do not understand how grapefruit juice actually works to increase absorption/bioavailability. Do you have some kind of problem with someone explaining how something actually works?

Actually, after reading a couple of your posts/threads nevermind I understand. http://anabolicminds.com/forum/supplements/62200-help-fellow-amr.html
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But, but, but I wuz trying to be fun-E. I guess my British sarcasm is lost on you Yanks sometimes. I apologize if you got all riled up. Sorry. :(

Much love,

<3 Neoborn <3
 
neoborn said:
But, but, but I wuz trying to be fun-E. I guess my British sarcasm is lost on you Yanks sometimes. I apologize if you got all riled up. Sorry. :(

Much love,

<3 Neoborn <3
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dont worry neo, you gotta be you. it turns out your post helped me learn some things.:hammer:
 
neoborn said:
But, but, but I wuz trying to be fun-E. I guess my British sarcasm is lost on you Yanks sometimes. I apologize if you got all riled up. Sorry. :(

Much love,

<3 Neoborn <3
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I am sorry also. When I read your post I was at work and the "sarcasm" image was blocked out so it just read as though it was just a random act of rudeness. Please accept my sincerest apologies for retaliation. J
 
jonny21 said:
I am sorry also. When I read your post I was at work and the "sarcasm" image was blocked out so it just read as though it was just a random act of rudeness. Please accept my sincerest apologies for retaliation. J
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:cheers: S'all good bro, much love. You came with the pwnage and gave out good quality information. You helped BigT and I both learn something. Thank you for being a true contributor here.:cheers:

Much Love,

<3 Neoborn <3
 
lets not get all mushy on eachother here fellas!!! this thread is about grapefruiits, in other words my testicles, wich are the size of grapfruits and neo if i ever see some non crazy ass mushy shiii like that from you agian your gonna get teabagged by these grapefruits in a grocery bag..... i love you :D
 
poopypants said:
lets not get all mushy on eachother here fellas!!! this thread is about grapefruiits, in other words my testicles, wich are the size of grapfruits and neo if i ever see some non crazy ass mushy shiii like that from you agian your gonna get teabagged by these grapefruits in a grocery bag..... i love you :D
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LOL you iz a funny guy there Mr.Poopyhead. I am aiming at grapefruits and hoping this Diesel Test Hardcore is going to do something for me :) If not I'm sure my epi pulse will.

Much Love,

<3 Neoborn <3
 
niiiice epi mmmm good luck bro, let me know how it works for you... n if you really are aiming for grapefruits then grab some toremifene, that stuff is tits at getting the balls big :thumbsup:
 
Hahahah. Nah I try to do as little chems as possible. I'm not for the kitchen sink / synthesized approach....much. :thumbsup: I am definitely going to log everything worthy of logging from here on in.
 
neoborn said:
:cheers: S'all good bro, much love. You came with the pwnage and gave out good quality information. You helped BigT and I both learn something. Thank you for being a true contributor here.:cheers:

Much Love,

<3 Neoborn <3
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As someone recently told me, stop trying to take this thread off-topic LOL. Stick to the message, save the man-love for a PMs.

While you'r at it, stash the Diesel Test for later and just pulse the Epi and do daily Form and you will be more than happy.
 
Dutchman said:
As someone recently told me, stop trying to take this thread off-topic LOL. Stick to the message, save the man-love for a PMs.

While you'r at it, stash the Diesel Test for later and just pulse the Epi and do daily Form and you will be more than happy.
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Well whoever told you, pff, you should definitely tell em to :FUfinger: and ave some of dis!:nutkick:

:thumbsup:
 
poopypants said:
creatine i belive is methylated..... dont quote me on it though.

either way it will basically increase absorbtion of most anything thats easily oxidized in the liver. methylation has nothin to do with it.
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No one addressed this that I can tell, so I wanted to ask. Creatine is methylated? Since when?!?!?!
 
Jmuls said:
No one addressed this that I can tell, so I wanted to ask. Creatine is methylated? Since when?!?!?!
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It's not. The rest of the post was false also. Grapefruit juice has little effect on liver hepatocytes. It will only increase absorption of chemicals that are metabolized by cytochrome P450 3A4 isoenzyme in the intestinal wall. I think it also down regulates other isoenzymes so it would increase absorption of those also.
 
jonny, you have definately done your research. could i get you to make a short list of generalized things that might positively be effected by gf juice. thanks.:thumbsup:
 
i might be a total ding dong. but is there grapefruit supplements? i know grapefruit stuff appears to be inside many supplements but is there a bulk powder or just grapefruit pills. i know i bought grapeseed which i realized isnt grapefruit hehe i forgot they are 2 diff things. no ones perfect.
 
thebigt said:
jonny, you have definately done your research. could i get you to make a short list of generalized things that might positively be effected by gf juice. thanks.:thumbsup:
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Grapefruit juice effects cyp-450 1A2, 3A4. I think Tamoxifen is mildly effected. If you could get some info from manufacturers regarding the metabolism of the chemicals that would tell you which ones will be effected by grapefruit juice. Any that are metabolized by cyp-450 1A2, 3A4 would have higher absorption rates with grapefruit juice.

Here is a list of drugs that are highly effected:
Drug name
Carbamazepine (Carbatrol, Tegretol)
Buspirone (BuSpar), clomipramine (Anafranil) and sertraline (Zoloft)
Diazepam (Valium), triazolam (Halcion)
Felodipine (Plendil), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular) and possibly verapamil (Isoptin, Verelan)
Saquinavir (Invirase) and indinavir (Crixivan) HIV medications
Simvastatin (Zocor), lovastatin (Mevacor, Altoprev) and atorvastatin (Lipitor), simvastatin-ezetimibe (Vytorin)
Cyclosporine (Neoral, Sandimmune), tacrolimus (Prograf) and sirolimus (Rapamune)
Amiodarone (Cordarone)
Methadone
Sildenafil (Viagra) Erectile dysfunction medication
 
thanks. you are the source for this topic.:clap2:
 
jonny21 said:
Grapefruit juice effects cyp-450 1A2, 3A4. I think Tamoxifen is mildly effected. If you could get some info from manufacturers regarding the metabolism of the chemicals that would tell you which ones will be effected by grapefruit juice. Any that are metabolized by cyp-450 1A2, 3A4 would have higher absorption rates with grapefruit juice.

Here is a list of drugs that are highly effected:
Drug name
Carbamazepine (Carbatrol, Tegretol)
Buspirone (BuSpar), clomipramine (Anafranil) and sertraline (Zoloft)
Diazepam (Valium), triazolam (Halcion)
Felodipine (Plendil), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular) and possibly verapamil (Isoptin, Verelan)
Saquinavir (Invirase) and indinavir (Crixivan) HIV medications
Simvastatin (Zocor), lovastatin (Mevacor, Altoprev) and atorvastatin (Lipitor), simvastatin-ezetimibe (Vytorin)
Cyclosporine (Neoral, Sandimmune), tacrolimus (Prograf) and sirolimus (Rapamune)
Amiodarone (Cordarone)
Methadone
Sildenafil (Viagra) Erectile dysfunction medication
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Quercetin and piperine is also a good agent to increase bioavailablity of nutrients. Does grapefruit effect the same enzymes as quercetin and piperine?
 
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