when to take 6oxo
- 06-24-2003, 10:13 PM
- 06-24-2003, 11:46 PM
3-Alpha acts as a strong anti-aromotase by itself. Does anyone know if DHT sends a negative signal to the HTPA to the same degree as testosterone or estrogen? If it doesn't , 3-Alpha stacked with a receptor antagonist like clomid or nolva may make for a very effective post cycle stack.
06-25-2003, 02:29 PM
so what do think, take the 6oxo(i already have 2 bottles) with the 3alpha or wait until 3alpha is done?
06-27-2003, 03:14 PM
Its seems that DHT does in fact inhibit the release GnRH and is thus supressive. Although, DHT does not exert its effect at the hypothalamus, like Test and Estrogen. The mechanism of action by which DHT supresses LH is unknown. This bottom line is that DHT is supressive, and although it is an anti-aromatase, it should be treated like any androgen and post cycle meds should follow its use.
Regulation of gonadotrophin-releasing hormone secretion by testosterone in male sheep.
Hileman SM, Jackson GL.
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
In males, including the ram, testosterone, acting via its primary metabolites oestradiol and dihydrotestosterone (DHT), suppresses circulating LH concentrations. This effect is due primarily, although not totally, to decreased frequency of gonadotrophin-releasing hormone (GnRH) pulses. The arcuate-ventromedial region (ARC-VMR) of the mediobasal hypothalamus and possibly the medial preoptic area (mPOA) are sites at which oestradiol acts to suppress GnRH, but the site of DHT action is not known. Given that native GnRH neurones appear to contain few or no oestrogen or androgen receptors, the effects of testosterone metabolites probably are exerted by modulating activity of inhibitory interneurone systems such as beta-endorphin, dopamine, and gamma-aminobutyric acid (GABA). Although beta-endorphin clearly inhibits GnRH secretion, the observation that testosterone treatment during a long-day photoperiod reduced proopiomelanocortin (POMC) mRNA in the arcuate nucleus while coincidentally suppressing GnRH release indicates that beta-endorphin does not mediate the inhibitory effect of testosterone on GnRH. Activation of GABAA receptors in either the mPOA or ARC-VMR suppressed LH, whereas activation of GABAB receptors in the ARC-VMR increased LH pulse amplitude. Therefore, it is suggested that GABA acts in both regions to regulate LH. Whereas testosterone affects GABA metabolism in the rat hypothalamus, its effect in the ram hypothalamus is yet to be determined. Testosterone treatment activated dopaminergic cells in the retrochiasmatic A15 area in the same animals in which it suppressed POMC mRNA in the arcuate nucleus. This dopaminergic system may partially mediate the negative feedback effect of testosterone in the ram analogous to its role in partially mediating the negative effect of oestrogen in the ewe. Future studies must concentrate on determining how these and other putative inhibitory neuronal systems interact and how they in turn are regulated by environmental factors such as photoperiod.
06-27-2003, 03:22 PM
06-27-2003, 04:05 PM
Because formasin is an anti-aromatise. 3-Alpha is a strong anti-aromatise. No need to take both concurently.Originally posted by Blacksmith
Why not go with Formasin throughout the entire cycle and add the 60X0 at the end ?
06-27-2003, 04:38 PM
Maybe, but using Formasin during the 1-Test,4AD cycle can only help the situation IMO.Originally posted by bow
3-Alpha is a strong anti-aromatise. No need to take both concurently.
3-Alpha does not Aromatise but I've not heard it touted as a suicide inhibitor of estrogen. The residual effects of 4AD conversion may or may not be inhibited by 3-alpha.
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