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whats the scoop on this. never herd or found much info on this. supposly raise your bodys temp,burn fat. ??
Search function?whats the scoop on this. never herd or found much info on this. supposly raise your bodys temp,burn fat. ??
This study shows that doses of 1 mcg/kg BW induce apoptosis (programmed cell death) in heart tissue. Humans ingest this much clen quite often, for instance, in a 220 lb (100 kg) bodybuilder this translates to 100 mcg.J Appl Physiol. 2004 Dec 10; [Epub ahead of print] Related Articles, Links
{beta}2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.
Burniston JG, Tan LB, Goldspink DF.
Research Institute for Sports and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom.
High doses of the beta2-adrenergic receptor (AR) agonist, clenbuterol, can induce necrotic myocyte death in the heart and slow-twitch skeletal muscle of the rat. However, it is not known if this agent can also induce myocyte apoptosis and whether this would occur at a lower dose than previously reported for myocyte necrosis. Male Wistar rats were given single subcutaneous injections of clenbuterol. Immunohistochemistry was used to detect myocyte specific apoptosis (detected on cryosections using a caspase 3 antibody and confirmed using annexin V, single-strand DNA labelling and TUNEL). Myocyte apoptosis was first detected at 2 h, and peaked 4 h after clenbuterol administration. The lowest dose of clenbuterol to induce cardiomyocyte apoptosis was 1 microg kg(-1), with peak apoptosis (0.35 +/- 0.005 %; P<0.05) occurring in response to 5 mg kg(-1) . In the soleus, peak apoptosis (5.8 +/- 2 %; P<0.05) was induced by the lower dose of 10 microg kg(-1). Cardiomyocyte apoptosis occurred throughout the ventricles, atria and papillary muscles. However, this damage was most abundant in the left ventricular subendocardium at a point 1.6 mm, that is, approximately one-quarter of the way from the apex towards the base. beta-AR antagonism (involving propranolol, bisoprolol or ICI 118,551) or reserpine was used to show that clenbuterol-induced myocardial apoptosis was mediated through neuromodulation of the sympathetic system and the cardiomyocyte beta1-AR, whereas in the soleus direct stimulation of the myocyte beta2-AR was involved. These data show that when administered in vivo, beta2-AR stimulation by clenbuterol is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively.
two weeks. its messing with my strength a bithow long u been on it?
yeah dont get drunk and poor the bottle into a shot glass!!!It's also pretty dangerous sh*t. Make sure you know what the heck you're doing before jump on the clen-wagon.
I feel this way about Triac too. Can't speak for T3, as I have never used it...I keep seeing Clen brought up. I really feel the more educated members should take initiative to inform people (especially the youngins) about the possible dangers of Clen. IMO, its much more unhealthy than anabolics.
Tiratricol (TRIAC - 3,5,3' -triiodothyroacetic acid) is a thyroid drug used in combo with levothyroxine. It has thryoid hormone like activity and can inhibit the secretion of TSH by the pituitary gland. All that has happened is an FDA issued a warning about supplements which contained it. It's pretty safe. Clen on the other hand is not RX'd in American anymore (illegal). Besides that, synthetic T3 is not the same thing.I feel this way about Triac too. Can't speak for T3, as I have never used it...
ok......... im not doing anymore clen. thats too much danger for my heart.Tiratricol (TRIAC) is a thyroid medication used in combo with levothyroxine. It inhibits the thyroid and secretion of TSH by the pituitary gland. It is worse than running synthetic T3 imo.
I really dont think the heart damage of clen compares to minor suppression of the thyroid.
Study after study, the thyroid is shown to be fairly resilient (even more so than the testes). It is pretty hard to perm. damage the thyroid with educated use (vs. abuse). There are BB's who have abused t3 years on end and still had their thyroid recover fully. In fact, its pretty common.
Obviously t3 has its dangers, but so does testosterone. I feel clen belongs in a category all its own. There is no therapeutic range where damage wont occur like with t3 or test. In other words, you need to use around 100mcg for any benefit and this is enough to damage the heart. So if you use even the modest recommended doses, heart tissue apoptosis can occur.
"Minor suppression", that's funny, where do you gather that? I have bloodwork done showing complete shutdown. Also it took a very, very long time to see my thyroid hormones back to baseline... From using Triac while on A A S.Tiratricol (TRIAC - 3,5,3' -triiodothyroacetic acid) is a thyroid drug used in combo with levothyroxine. It has thryoid hormone like activity and can inhibit the secretion of TSH by the pituitary gland. All that has happened is an FDA issued a warning about supplements which contained it. It's pretty safe. Clen on the other hand is not RX'd in American anymore (illegal). Besides that, synthetic T3 is not the same thing.
I really dont think the heart damage of clen compares to minor suppression of the thyroid.
You can be TOTALLY shut down from testosterone use too. Is that in and of itself even comparable to clen heart damage? In the case of t3 and test, an overwhelming majority bounce back easily. Suppression is a moot point..."Minor suppression", that's funny, where do you gather that? I have bloodwork done showing complete shutdown. Also it took a very, very long time to see my thyroid hormones back to baseline... From using Triac while on A A S.
I'm not trying to compare thyroid suppression to heart damage, or apples to oranges for that matter, just pointing out that it's bad practice to advise people looking to lose a few pounds to turn to thyroid drugs (which I see or have seen in the past this advice far too often). Most of these people are already cycling A A S, and don't really need to mess with another hormonal axis.
Just my two cents...
You can be TOTALLY shut down from testosterone use too. Is that in and of itself even comparable to clen heart damage? In the case of t3 and test, an overwhelming majority bounce back easily. Suppression is a moot point...
also...
A) Im talking about t3 suppression (TRAIC is garbage, notorious for more shutdown and less effect than regular t3)
B) minor as in permanence, not severity of shut down. If it works, you should be shut down.
Clen and t3 dont compare. I knew someone was going to open their mouth and say "oh but t3 is dangerous too" .. whatever. The point of the post is that Clen needs to be retired, its not open to debate.
Im not going to go on and on about why suppression from t3 or testosterone is or isnt bad. The difference between clen is like night and day. You could have just as easily said "I feel the same way about Tren..," why would you bother in either case, I have no idea... T3 and Clen are not comparable in risk. There is a reason Clen was completely banned. Its not a good/bad discussion. Its a lesser of two evils discussion. In which case t3 is much better. People are going to use what works. I'm just trying to show them that Clen isnt worth it.
TSH was shut down almost immediately after starting dosing. It was actually much longer than 3 months for my Total T4, FT4, Total T3, and FT3 to come back to the area of baseline. My baselines were in the middle of the normal range, and for many months they were at the very bottom of the normal range. Keep in mind, I was still on A A S for a while after stopping the Triac. It was still months after stopping everything before my thyroid hormones were back to my baseline.Correct me if I'm wrong , SS, but didn't it take something like 3 months for your T3/T4/TSH levels to return to normal after taking Triac? And weren't they shutdown completely almost immediately?
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