What's the difference between 17aa and Methyl?

[Zero Tolerance]

I'm guessing 17aa is more liver toxic.. But what's the difference? I've been wondering about this and haven't found anybody discuss it...

 

[thesinner]

17aa stands for 17-alpha-alkylated

Methyl is a type of alkylation, having only 1 carbon. Ethyl is 2 carbons, propyl is 3 carbons, butyl is 4 carbons.......... I think you get the picture.

If it's on the 17th alpha carbon of the steroid ring, that methyl may cause some liver toxicity.

 

[Zero Tolerance]

So am I right by saying that Anadrol is 17aa and, say, Pheraplex is 17ma? That sounds a little wierd...

 

[thesinner]

So am I right by saying that Anadrol is 17aa and, say, Pheraplex is 17ma? That sounds a little wierd...

If you look at the compound name, and see 17-methyl, #,17-dimethyl, 17-ethyl, etc. Then it is more than likely 17a alkylated.

 

[Zero Tolerance]

Okay. So 17-a-methyl is basically the same as a C17aa.. So a product like Epistane (which is somehow easy on the liver for a methyl) could technically be in the same 'league' as Anadrol (without specifically delivering the same results). Very confusing.

I figured that anything which was C17aa was very dangerous. However, it seems as if this is not always the case...

 

[thesinner]

Epistane still has some liver toxicity to it, but not as bad as others.

Pharmacokinetics plays a big role on how methyls effect the liver. It's actually the metabolites of the methyls that do the majority of the damage. Depending on how the different methyls metabolize will cause varying amounts of damage on the liver.

 

[Zero Tolerance]

Thank you for the explanation.. It does make sense, in a somewhat beyond-me kinda way.

 

[TeamSavage]

Basically, "17aa" and "methyl" mean the same thing when used on this board. Chemically speaking "methyl" is just a CH3 group which can be found in all sorts of compounds (like caffeine, for instance), but when people say "Superdrol is a methyl" they mean that it's methylated at the 17aa position. Many steroids are methylated at the 17aa position to make them orally active (it helps prevent breakdown in liver), but this also generally makes them more liver toxic. As Sinner mentioned, though, the liver toxicity can vary greatly from poisonous (M1T) to not-too-bad (Epi/Havoc).

 

[thesinner]

Basically, "17aa" and "methyl" mean the same thing when used on this board. Chemically speaking "methyl" is just a CH3 group which can be found in all sorts of compounds (like caffeine, for instance), but when people say "Superdrol is a methyl" they mean that it's methylated at the 17aa position. Many steroids are methylated at the 17aa position to make them orally active (it helps prevent breakdown in liver), but this also generally makes them more liver toxic. As Sinner mentioned, though, the liver toxicity can vary greatly from poisonous (M1T) to not-too-bad (Epi/Havoc).

:toofunny: