Your guys thoughts on this

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    Kitchen Chemist's Avatar
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    Your guys thoughts on this


    This is a topical product that a UG lab is making, every time i see this it baffles me on why they put 25% DMSO in it if its for spot reduction.


    Qfs Dinoprost-gel, Transdermal Fat Reduction, Pgf-2a
    QFS Dinoprost-Gel, Transdermal Fat Reduction active ingredients
    Dinoprost Tromethamine 150mg ( Prostraglandin F2 alpha) and
    Dimethylsulfoxide (DMSO 25%)
    Prostaglandin F2alpha is a potent inhibitor of adipocyte precursor
    differentiation and a physiological negative modulator of adipocyte
    function (ie triglyceride accumulation) through stimulation of
    transforming growth factor-alpha mRNA expression. It initiates a
    cascade of effects in the adipoctes which have physiological
    importance to reducing the size and it appears number of mature
    cells,long after PGf-2a is cleared from the system

    Mature adipose cells only shrink in size in response to restricted
    caloric intake or increased metabolic demand. Before now the only
    method of reducing the number of fat cells was liposuction. It now
    appears that Pgf-2a applied topically can have the same same
    effects as diet and liposuction. Pgf-2a can reduce the size of
    mature adipocytes and the number of mature adipocytes through
    negative modulation and reversing the process of differentiation

    There are no studies on topical application. DMSO does carry PGF-2a
    through the dermal layers and the low concentration spread over a
    large area is ideal for the intended purpose. One cannot spread
    PGf-2a (or anyother substance) over the surface area that one can
    with DMSO topical application. The idea being that you need to
    interact as many molecules of PGF-2a with as many mature fat cells
    as possible. The biggest asset to DMSO as a carrier is the ability
    to spread the PGF-2a applicatiion over a large surface area,
    thereby maximising the interactuion of the number PGF-2a molucules
    with the maximum number of fat cells. This is where the DMOS method
    really shines. QFS is not masking the smell of the DMSO. It is not
    that bad and goes away in about 5 minutes.

    It is important to remember that dinoprost tromethamine does not
    burn the released fatty acids, aerobic exercise and or T3 will take
    care of that. PGF-2a only changes the way fats are stored and the
    formation and function of adipose tissue. As well I find that about
    half of the time I feel a tickle in the back of my throat and
    sometimes I have a full out coughing fit. This says to me that I
    have applied a good dosage.


    Here are some studies that support PGF-2a and negative modulation
    of adipose tissue.
    Endocrinology 1995 Aug;136(8):3222-9
    Prostaglandin F2 alpha stimulates transforming growth factor-alpha
    expression in adipocyte precursors.
    Lepak NM, Serrero G.
    W. Alton Jones Cell Science Center, Inc., Lake Placid, New York
    12946, USA.

    Transforming growth factor-alpha (TGF alpha) and prostaglandin F2
    alpha (PGF2 alpha) are potent inhibitors of adipocyte
    differentiation. We demonstrate here that TGF alpha messenger RNA
    (mRNA) is expressed in freshly isolated fat pads and in primary
    culture of adipocyte precursors cultivated in defined medium before
    and after differentiation. We show that PGF2 alpha stimulated TGF
    alpha mRNA expression in a dose-dependent manner. PGF2 alpha also
    stimulated TGF alpha production in the culture medium of adipocyte
    precursors in primary culture. PGF2 alpha stimulated TGF alpha mRNA
    expression in both undifferentiated and differentiated cells. 9
    alpha,11 beta-PGF2 alpha, which also inhibited adipose
    differentiation, stimulated TGF alpha mRNA expression similarly to
    PGF2 alpha, whereas other PGs had no effect on TGF alpha mRNA
    expression. The time-course experiment indicates that the
    stimulation of TGF alpha mRNA expression by PGF2 alpha is observed
    within 6 h of exposure to PGF2 alpha and is inhibited by treatment
    of the cells with actinomycin D. The effect of PGF2 alpha on TGF
    alpha expression did not require activation of protein kinase C and
    was fully reversible. As both TGF alpha and PGF2 alpha are
    inhibitors of adipose differentiation, it is suggested that
    stimulation of TGF alpha expression by PGF2 alpha could represent
    an amplification mechanism to modulate adipocyte precursor
    differentiation and adipocyte function within the adipose tissue.

    Int J Obes Relat Metab Disord 1996 Mar;20 Suppl 3:S58-64 R
    Endocrine and paracrine negative regulators of adipose
    differentiation.
    Serrero G, Lepak N.
    W Alton Jones Cell Science Center, Inc, Lake Placid, NY 12946, USA.
    Obesity which is characterized by an abnormal adipose tissue
    development is a first degree public health hazard in
    industrialized countries. One important aspect in the study of
    adipose tissue development is to investigate the hormonal control
    of proliferation and differentiation. Any qualitative or
    quantitative change in these hormones or their receptors can result
    in abnormalities in the process of proliferation and/or
    differentiation possibly leading to obesity. Therefore, it is
    important to identify these factors and investigate their mechanism
    of action. We have concentrated our efforts in the study of factors
    triggering differentiation (positive regulators) and also of
    factors inhibiting differentiation (negative regulators). The
    present paper provides evidence of the importance of EGF/TGF-alpha
    and of PGF2 alpha as differentiation inhibitors for adipocyte
    precursors in primary culture. Data presented here also demonstrate
    that TGF-alpha is expressed in adipose tissue and that its
    expression is specifically stimulated by PGF2 alpha, thus
    suggesting the existence of an amplification mechanism between two
    differentiation inhibitors within the adipose tissue. The
    importance of these two types of differentiation inhibitors in the
    regulation of adipose tissue development is discussed.

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    elijah_123's Avatar
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    My thought would be pgf2a's short half life (15 minutes). I would guess the dmso is there to ensure it gets through the skin and reaches fat cells before it is metabolized away.

    I would love to see how this works in to areas.
    First is fat reduction I'm sure if it gets the pgf2a through quick enough it will work great.
    Second is for guys with super low bf. I am curious if this will help with spot growth if it gets directly to the muscle.
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    Not to get off topic very much, but I've been told about DMSO and Yohimbe Hcl for spot reduction for fat loss.. Any thoughts on it and how would you dose it... ie proper mix of the two...

    Thanks for any help..
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    I have seen guys talk about DMSO and Yo HCL for spot fat loss. But I also saw some convincing posts saying all it does is get it into the blood stream so does nothing for spot reduction.
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    Originally posted by CROWLER
    I have seen guys talk about DMSO and Yo HCL for spot fat loss. But I also saw some convincing posts saying all it does is get it into the blood stream so does nothing for spot reduction.
    That is my exact thoughts or else it would be easy as hell to make your own homebrew as all you would need is dmso and y-hcl not like 7 other ingredients lol. I've posted this about a couple products as these canadian UG labs are starting to sell dmso/yoh mixes which to me makes no sense. I have a thread in the R&D section aswell about this.
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    KC, did you get this from CJM?? I saw this as well. Im a little curious about it. Still 25% seems alot.

    Peace

    Bone
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    Yeah i did bone, i asked bonebender about there yohimbine prod aswell, made with 100% dmso. It's on cjm aswell.
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    Seems like wayyyy to much to me. But what do I know LOL

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    Is there a safe version of transdermal lutalyse for women.I can see why its not good intravenous for women but transdermally its much weaker side effects.know where someone could buy some?
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    I hear that it does nothing for muscle growth transdermally.ive studied alot about it online
  

  
 

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