I was originally having this discussion here.
...but I believe that is the wrong place to continue it... I'm copying and pasting some information from that discussion here and will continue..
STABLE TESTOSTERONE LEVELS ACHIEVED
WITH SUBCUTANEOUS TESTOSTERONE
M.B. Greenspan, C.M. Chang
Division of Urology, Department of Surgery, McMaster University,
Hamilton, ON, Canada
Objectives: The preferred technique of androgen replacement
has been intramuscular (IM) testosterone, but wide
variations in testosterone levels are often seen. Subcutaneous
(SC) testosterone injection is a novel approach; however,
its physiological effects are unclear. We therefore investigated
the sustainability of stable testosterone levels using
SC therapy. Patients and methods: Between May and
September 2005, we conducted a small pilot study involving
10 male patients with symptomatic late-onset hypogonadism.
Every patient had been stable on TE 200 mg IM for
41 year. Patients were instructed to self-inject with
testosterone enanthate (TE) 100 mg SC (DELATESTRYL
200 mg/cc, Theramed Corp, Canada) into the anterior
abdomen once weekly. Some patients were down-titrated
to 50 mg based on their total testosterone (T) at 4 weeks.
Informed consent was obtained as SC testosterone administration
is not officially approved by Health Canada. T
levels were measured before and 24 hours after injection
during weeks 1, 2, 3, and 4, and 96 hours after injection
in week 6 and 8. At week 12, PSA, CBC, and T levels
were measured however; the week 12 data are still being
collected. Results: Prior to initiation of SC therapy, T
was 19.14+3.48 nmol/l, hemoglobin 15.8+1.3 g/dl, hematocrit
0.47+0.02, and PSA 1.05+0.65 ng/ml. During
the first 4 weeks, there was a steady increase in
pre-injection T from 19.14+3.48 to 23.89+9.15 nmol/l
(p¼0.1). However, after 8 weeks the post-injection T
(25.77+7.67 nmol/l) remained similar to that of week 1
(27.46+12.91 nmol/l). Patients tolerated this therapy with
no adverse effects. Conclusions: A once-week SC injection
of 50–100 mg of TE appears to achieve sustainable and
stable levels of physiological T. This technique offers
fewer physician visits and the use of smaller quantity of
medication, thus lower costs. However, the long term
clinical and physiological effects of this therapy need further
evaluation.On 03.01.2007, I injected testosterone cypionate 300mg/ml subcutaneously just above my navel. I used a 29 gauge insulin needle to inject .50ml (for 150mg total). It took a couple of minutes to draw the oil (not warmed or anything). It took about a minute to inject and a tiny bit of oil was on my skin when I removed the needle..Saudi Med J. 2006 Dec;27(12):1843-6
Subcutaneous administration of testosterone. A pilot study report.Al-Futaisi AM, Al-Zakwani IS, Almahrezi AM, Morris D.
Department of Medicine, College of Medicine & Health Sciences, PO Box 35, Postal Code 123, Al-Khod, Sultanate of Oman. Tel. +968 99475401. Tel/Fax. +968 24413419. E-mail: firstname.lastname@example.org.
OBJECTIVE: To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients. METHODS: All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Monteral, Quebec, Canada, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administer weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. RESULTS: A total of 22 patients were enrolled in the study. The mean trough was 14.48 +/- 3.14 nmol/L and peak total testosterone was 21.65 +/- 7.32 nmol/L. For the free testosterone the average trough was 59.94 +/- 20.60 pmol/L and the peak was 85.17 +/- 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. CONCLUSION: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and trough levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.
PMID: 17143361 [PubMed - in process]
The day after, the area was a little pink and warm. The day after that, the pink spread a bit. By the third day, the pinkness was going away, it wasn't warm anymore - and the area was a tiny bit itchy.
Today, on the fourth day, the pinkness is almost completely gone...
I'm considering trying this again today (should be every 3 days) with .30ml into each side of my stomach.
There are four or five of us trying this experiment here at AM. "Crunch" did 1ml of Sustanon 250 into each thigh yesterday and all seems to be going well for him so far.
"Hotspot" tried .5cc of Cypionate into the side of his abdomen (in an area without much fat) but after 49 hours - he gave up due to a lump like a "bee sting" that was very sore...
I'm waiting on my next injection(s) because I'd like to see how Crunch is progressing - along with a couple of other guys who've tried this out (who we haven't heard back from).
What do you guys think in regards to the possibility of abcesses? Is injecting an oil-based steroid into subcutaneous fat asking for trouble? Even at .30ml? Dr. Eugene Shippen (a popular HRT doctor) has chosen this to be the method for his patients.. So how bad could it be without any report from him of problems?
I'm open for input. If I do continue, I'll be getting blood tests to see where I'm at in the new future...