B12 and the Metabolic Rate
05-29-2003 11:16 PM
B12 and the Metabolic Rate
For my buddy John B.....It's a great read
Vitamin B12, also known as cobalamin, is naturally found in food such as fish, milk and milk products, eggs, meat and poultry. Fortified breakfast cereals are another source of vitamin B12 and a valuable source for vegetarians. Vitamin B12 is important for good health, necessary for the proper digestion and absorption of foods and for normal metabolism of carbohydrates, and fat. It helps maintain healthy nerve cells and red blood cells and is needed to make DNA. Vitamin B12 is bound to the protein in food. Hydrochloric acid in the stomach releases B12 from protein during digestion. Vitamin B12 was isolated from a liver extracted in 1948 and identified as the nutritional factor in liver that prevented pernicious anemia, a deadly type of anemia characterized by large, immature red blood cells.
In order to absorb the small amounts of vitamin B12 found in food, the stomach secretes intrinsic factor, a special digestive secretion that increases the absorption of vitamin B12 in the small intestine. Unlike other water-soluble nutrients, vitamin B12 is stored in the liver, kidney, and other body tissues. It can take several years before signs of the deficiency appear, all because of poor dietary intake. Vitamin B12 functions as a "methyl donor." A methyl donor is a compound that carries and donates methyl groups to other molecules, including cell membrane components and neurotransmitters. As a methyl donor vitamin B12 is involved in homocysteine metabolism and plays a critical role in proper energy metabolism, immune function, and nerve function. Therefore, vitamin B12 is clearly an added benefit for anyone wanting to lose weight, as without it, metabolism is not at its peak potential.
Dosing for vitamin B12 is dependent on the age of the individual as well as if the patient is pregnant or lactating. Vitamin B12 is necessary in only very small quantities No one has ever reported clear toxicity from vitamin B12.
05-29-2003 11:37 PM
I am faster than 80% of all snakes
Vitamin B12 treatment normalizes metabolic markers but has limited clinical effect: a randomized placebo-controlled study.
Hvas AM, Ellegaard J, Nexo E.
Department of Hematology, AAS, Aarhus University Hospital, Tage Hansens Gade 2, 8000 Aarhus C, Denmark. firstname.lastname@example.org
BACKGROUND: The clinical significance of increased plasma methylmalonic acid (P-MMA) is unclear. We assessed the efficacy of vitamin B12 treatment in reducing P-MMA and plasma total homocysteine compared with the clinical benefits of treatment. METHODS: We studied 140 individuals with mildly to modestly increased P-MMA (0.40-2.00 micromol/L), not previously treated with vitamin B12, in a randomized, placebo-controlled study. A detailed medical history was obtained, and laboratory tests as well as an objective neurologic disability score were performed at baseline and 3 months after the start of intervention. RESULTS: P-MMA (P <0.001) or plasma total homocysteine (P <0.001) decreased in the treatment group vs the placebo group, but no significant difference was found in the change of blood hemoglobin (P = 0.18) and mean cell volume (P = 0.71). Changes in symptom scores did not differ between the groups for symptoms of anemia (P = 0.63), neurologic symptoms (P = 0.21), gastroenterologic symptoms (P = 0.32), or the Neurological Disability Score (P = 0.85). CONCLUSIONS: Treatment with vitamin B12 reduces P-MMA and plasma total homocysteine, but individuals with a mild to modest increase in P-MMA may have only limited clinical benefit from vitamin B12 treatment, at least in the short term.
05-29-2003 11:59 PM
Nice study bet it was taken oraly.....?
05-30-2003 12:38 AM
I am faster than 80% of all snakes
No. B-12 treatment is not oral.
05-30-2003 01:29 AM
European Journal Of Haematology
Volume 67_Issue 2_Page 123_ - August 2001
Abstract: Human cobalamin deficiency: alterations in serum tumour necrosis factor-alpha and epidermal growth factor.
Peracchi M, Bamonti Catena F, Pomati M, De Franceschi M, Scalabrino G.
Department of Medical Sciences, Chair of Gastroenterology and Chair of Hematology, University of Milan, IRCCS Ospedale Maggiore, Italy.
OBJECTIVES: We have previously demonstrated that vitamin B12 (cobalamin)-deficient central neuropathy in the rat is associated with local overexpression of neurotoxic tumour necrosis factor (TNF)-alpha combined with locally decreased synthesis of neurotrophic epidermal growth factor (EGF). The aims of this study were to investigate whether a similar imbalance also occurs in the serum of adult patients with clinically confirmed cobalamin deficiency and whether it can be corrected by vitamin B12 replacement therapy. PATIENTS AND METHODS: We studied 34 adult patients with severe cobalamin deficiency, 12 patients with pure iron deficiency anaemia and 34 control subjects. Haematological markers of cobalamin deficiency and serum TNF-alpha and EGF levels were measured using commercial kits. Thirteen cobalamin-deficient patients were re-evaluated after 3 and 6 months of parenteral vitamin B12 treatment. RESULTS: TNF-alpha was significantly higher (p < 0.01) and EGF significantly lower (p < 0.01) in the patients with cobalamin deficiency, but both were unchanged in patients with pure iron deficiency anaemia. In cobalamin-deficient patients the serum TNF-alpha levels correlated significantly with plasma total homocysteine levels (r = 0.425; p < 0.02). In the treated patients TNF-alpha and EGF levels normalised concomitantly with clinical and haematological disease remission. CONCLUSIONS: In humans, as in rats, cobalamin concentration appears to be correlated with the synthesis and release of TNF-alpha and EGF in a reciprocal manner, because cobalamin deficiency is accompanied by overproduction of TNF-alpha and underproduction of EGF.
05-30-2003 01:40 AM
Metabolism 1994 Apr;43(4):468-9
Reversal of severe osteoporosis with vitamin B12 and etidronate therapy in a patient with pernicious anemia.
Melton ME, Kochman ML.
Department of Internal Medicine, University of Michigan, Ann Arbor.
Pernicious anemia has recently been recognized as a risk factor for osteoporosis and fractures. Although vitamin B12 is important for osteoblast function, the effect of vitamin B12 replacement in states of vitamin B12 deficiency on bone density and fracture incidence is not known. We report 2-year follow-up data from a patient with severe osteoporosis, multiple vertebral compression fractures, and pernicious anemia who exhibited a dramatic response to treatment with vitamin B12 and cyclic etidronate. Serial bone density measurements demonstrated a 15% and 17% increase in the lumbar and greater trochanter regions, respectively, and a 79% increase in the femoral neck region over the 2-year follow-up period. In addition to normalization of bone density compared with age-matched controls, no subsequent vertebral fractures were noted in the 2-year period following initiation of vitamin B12 and etidronate therapy. This case demonstrates that osteoporosis associated with pernicious anemia may be markedly improved by vitamin B12 replacement and cyclic etidronate therapy.
05-30-2003 01:51 AM
South Med J 1991 Dec;84(12):1475-81
Myths about vitamin B12 deficiency.
Fine EJ, Soria ED.
Department of Neurology, School of Medicine, State University of New York, Buffalo.
Neurologic manifestations of vitamin B12 deficiency are protean, including neuropathy, depression, and dementia. We present evidence to dispel confounding myths about vitamin B12 deficiency. Hematologic indices are normal in up to 30% of patients with vitamin B12 deficiency, and results of the Schilling test may be normal in patients with symptoms of deficiency. Isolated neuropathy or myelopathy may occur independently, but often appear concurrently. The neuropathy is primarily axonal and predominantly sensory. Myelopathy is caused by demyelinated areas in posterior and lateral columns. After therapy, recovery from neuropathy is incomplete or may extend for several years. Vitamin B12 replacement should not be withheld from patients with borderline vitamin B12 levels, since the consequences of allowing myelopathy, neuropathy, dementia, and mental disorders to worsen clearly outweigh any disadvantage of therapy.
05-30-2003 05:19 PM
Okay so what you trying to say......you guys are going back and forth ...
I say try it. it won't hurt you ..but it may just give you energy to fly....right over to the local butcher's and eat a whole dead Cow....Ha Ha
05-30-2003 06:43 PM
I am faster than 80% of all snakes
But it might not. My study was posted for the sole purpose of stating that its clinical use is far from magical or even necessary to some for its metabolic effects.
06-02-2003 10:04 PM
My family raises equine.
I noticed a bottle of B12 in the fridge at the barn yesterday.
Is there a diffeance between Vetenarian B12 and human grade B12?
06-02-2003 10:58 PM
Human grade is supposedly much better, remember hearing it in a long thread by SHOT. I used the animal grade 1 cc ed for a month without any magic. It was mostly to practice site injections and see if it would help appetite and whatnot. Now that I'm off it I don't feel a difference. I would try human grade in the future, they actually come in amps rather than a big bottle, but the costliness of price exceeds my curiosity.
06-02-2003 11:24 PM
sweety if you would like I will send you a vial ...we have been friends for a while. I wouldn't take vet vitamins usp 24 can have up to 6% impurity's by law.....that a lot of crap to inject with out knowing what it is ...
vet b12 is oil based too ....
and to the rest of you Sale Sale Sale its ...cheep now
06-02-2003 11:49 PM
Mine is defintely not oil based. Aren't they all water soluble?? It looks red in the syringe but turns yellow on your fingers. I have had no problems, but I am willing to believe that it may not be 100% pure...not many things are. How much are human grade ones?
06-03-2003 12:20 AM
The one I saw yesterday was from our vet.......and it was not oil based. It was in a dark vial but I could tell it was red and a thin liquid.
06-03-2003 01:38 AM
I haven't encountered water based vet b12 but that doesn't mean it isn't made. human grade will cost you $1 per ml + s/h......
06-03-2003 01:00 PM
Mine is by AgriLabs, 250 mL bottle, for less than $20. I use a 25g to draw and shoot, very easy. I'll keep the human grade in mind for when I get some extra money.
06-03-2003 01:44 PM
SO, IS THERE ANY BENEFIT FROM TAKING UNI-LIVER TABS? I PRESENTLY TAKE 24 TABS DAILY
06-03-2003 03:18 PM
The True Warrior is one who conquers oneself
Originally posted by New Body SO, IS THERE ANY BENEFIT FROM TAKING UNI-LIVER TABS? I PRESENTLY TAKE 24 TABS DAILY
are you kidding or no? Taking uni-liver tabs is not the same as injecting B-12 if thats your question. But taking liver tabs are beneficial in my opinion. I definitely notice a difference in many areas when im taking them.
06-03-2003 05:05 PM
Sorry for souding stupid, but yes I was being serious. I personally have gotten great results from taking liver tabs, including higher energy level, quicker recovery, etc.
06-03-2003 05:35 PM
do what works for you .....
ok first off do what works for you. Everyone's body is different....
It depends on what you want out of the b12...... Energy ,maximum tissue growth, or increased appetite, or increased metabolic rate.........Bet you didn't know it did all of that.
Increased energy comes from an increased protein systhsis.
this aids in tussue growth.......Higher levels will work better for growth.
The increase in appetite is do to the fact that the body likes to have the b vitamins together in balanced levels. the cravings come from the body wanting more food to balance the vitamins . Kinda cool .....
this is why people have cravings when dieting the body craves the vitamins ...this is the secret of success to low card diets
Kynoselen is great stuff........and it's usp 27 (witch is human grade )
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