Originally Posted by xxtruxx1
I understand your concern. Here's probably the best answer/suggestion I can give.
First, let's understand what SHBG is, how it works, where it's produced, etc. Knowing about SHBG will help you make an informed decision.
SHBG, or sex hormone-binding globulin, is a glycoprotein which binds to sex hormones such as testosterone & estradiol (estrogen). Hormones bound to SHBG cannot enter a cell & activate the cell's receptor. If you were to get a blood test & check for bound testosterone, it would be test bound to SHBG. Only free hormones (free test) are bioavailable (able to enter the cell & activate its receptor). Therefore, SHBG inhibits the functions of hormones it's bound to. SHBG is produced in the liver & released into the bloodstream. SHBG is also produced by the brain, uterus (which we don't have to worry about), placenta, & testis.
Now that you know a little about SHBG, let's check out some possible causes.
You can have low or high levels of SHBG (obviously the only two choices). We'll focus on causes for high since that is your case. Some things that cause high SHBG levels are pregnancy (from what I know you don't have to worry about this), hyperthyroidism, & anorexia (more common in women, so screw this one too). Now, hyperthyroidism is a possibility. When was the last time you had your T3 & T4 levels checked? If I was you, I would recommend that you go back to your doctor & recommend that he has you take a blood test to check your thyroid levels. Tell him you further researched having high SHBG levels & concluded you wanted to get your thyroid checked. He might not go for it since you fall within normal levels of SHBG in a male (even though you are higher in the normal levels). You may also want to get your estrogen levels checked because high estrogen levels can also cause a rise in SHBG.
Now for control. There are ways to lower SHBG. You can decrease SHBG through use of insulin or IGF-1 (insulin-like growth factor 1). High androgen levels also decrease SHBG production & levels in the blood.
Now, my opinion. Get your free test levels checked. If they are within normal ranges for your age, do nothing. If they are not, check your estrogen & thyroid hormone levels. If your doctor won't give you anything, I would begin by taking a natural testosterone enhancer/booster. This would help by increasing levels of free test. You may also want to take an anti-e to decrease the amount of estrogen active in your body. Based on your S-Test levels, I would honestly tell you that you don't have much to worry about. If you are concerned, go to your doctor first & regurgitate everything you've learned & ask him to authorize those tests. Even if he doesn't, you can still hit the labs & have them done (but you will pay full price). This should help. Once you get these done, come back & we can help you further.
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