Aromasin info. The Best Anti-E?......

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    Aromasin info. The Best Anti-E?......


    very good read, will probably change your mind as to what anti e you use from here on out.

    written by superchicken (another board)

    theres been a lot of talk on other boards about this lately, and a lot of bad information thrown out as well. i wanted to share the good info.

    somone keeps posting how letrozole is the strongest and doesnt negatively affect cholesterol. this is not true. letrozole is NOT the strongest and it DOES negative affect cholesterol/lipid profile in a bad way.

    aromasin(exemestane) is the best. this is why

    both arimidex/ldex/anastrozole and femara/letrozole hurt your cholesterol. the way these 2 anti e's work is they inhibit the aromatase enzyme. by inhibiting the enzyme which converts testosterone to estrogen, you reduce or even come close to eliminating estrogen production. we need some estrogen to be healthy. the major drawback to this is without estrogen, your lipid profile gets ****ed.

    exemestane works differently. it does not stop the body from producing estrogen. rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. if the estrogen cannot bind, you simply will not get bloated or get gyno. the estrogen is crippled due to exemestane. however, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.

    anastrozole doesnt cause a rebound effect, and neither does exemestane, but letrozole does. this means after you stop the letrozole, your estrogen rebounds and goes pretty high for a while, eventually it normalizes. you can avoid this by tapering your letro dose down before stopping it, but that is a pain in the ass. higher than normal can mess many things up post cycle when you stop. since the hpta has a feedback loop is primarily controlled by estrogen, high estrogen will tell your hpta to produce less testosterone, because it thinks the high estrogen is caused by too much testosterone. this is fact. now post cycle, dont we want to raise our test levels, not lower them? of course! so rebounds are bad. if you use letro taper the dose off to zero over a couple weeks.

    fyi- nolvadex(tamoxifen) is a SERM(Selective Estrogen Receptor Modulator). this means on certain tissue it can act antagonisticaly or agonistically. in the case of lipid profiles, it acts agonistically. so, running tamoxifen with your anti e's will IMPROVE your cholesterol profile even if not on cycle or using any gear or other anti e's. its just plain good for cholesterol.

    one thing to keep in mind though when runing tamoxifen with letro. letro reduces blood levels of tamoxifen by over 50%. a study showed 2.5mg letro ed made nolva levels drop to 40% of what they were before adding letro. this does not mean you cant use tamoxifen with letro, it just means you need to use more, about double. 20mg of nolva will act like 8mg if running letro. so make sure you are aware of this because you will need to buy more nolva to compensate. this does not happen when mixing tamoxifen with anastrozole or exemestane, it only hppens with letro.

    also, many people and myself experince a reduction of libido on letro. this doesnt happen w/ ldex or exmestane as far as i know, and in my own experience, and ive run all 3 quite a bit.

    the best combo IS exemestane and tamoxifen together. your cholesterol will be as good as can be considering your on a cycle of steroids. the dose of aromasin will vary depending on the users needs and how much aromatizing gear is being taken. usually 10-25mg ed works well. run 10mg ed nolva to improve your cholesterol.

    second best combo i feel is anastrozole(ldex) and tamoxifen. ldex dose ranges from usually .15mg ed to 1mg ed. run 10mg nolva ed to improve cholesterol.

    thierd best is letro and nolvadex. letro doses usually range from 1-2.5mg ed. run 20mg ed nolva to improve cholesterol w/ letro.

    you do not need to run nolva with any of these 3, i do recomend it though as it will improve cholesterol compared to using the anti e's alone without nolva.

    so in order of strength, on a dose per dose basis(not mg per mg) aromasin is def the strognest, next is letro, and then ldex.

    ive been running aromasin now for about 4 months, i wont switch back to ldex or letro. it works much better and its much healthier for cholesterol profiles.

    i think we all need to stop only worrying about side effects that we can see visually. cholesterol KILLS many people around the world everyday(well not directly kills but leads to it). steroids are hrting us badly in this sense. steroids do mess our cholesterol up pretty badly, and we will pay for it later in life. now not many of us are going to stop using gear because of that, but we should at least take the proper other drugs to help minimize.

    aromasin is only a little bit more expensive than ldex or letro, and its actually about the same price as many places sell ldex or letro for. but its more powerful and healthier. people spend money all the time on steroids which dont have as many side effects as some of the harsher, cheaper steroids. a few extra bucks for the proper anti e's is def money well spent.

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    Quote Originally Posted by pistonpump
    exemestane works differently. it does not stop the body from producing estrogen. rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. if the estrogen cannot bind, you simply will not get bloated or get gyno. the estrogen is crippled due to exemestane. however, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.
    Would Exemestane be a good option for PCT (instead of SERM) to regenerate HPTA?
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    I have/do incorporated both. Aramosin is potent so you won't have to use much.
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    Quote Originally Posted by pistonpump
    very good read, will probably change your mind as to what anti e you use from here on out.

    written by superchicken (another board)

    .
    Sorry to get off subject
    Is this a new post or old? I haven't seen superchicken in ages. he and I go way back I actually turned his view around on halotestin.
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    Quote Originally Posted by Rage (SoCal)
    I have/do incorporated both. Aramosin is potent so you won't have to use much.
    how much do you use? i think half of the normal dose of 25mg would be sufficient on cycle. Do you use it more than the other anti-e's?

    If you think about it there has to be a reason it is more expensive. Im looking for some now and liquid looks like the cheapest....
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    I'll have to check the measurements. I'll get back to you.
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    Quote Originally Posted by Rostam
    Would Exemestane be a good option for post cycle therapy (instead of SERM) to regenerate HPTA?
    I wouldnt think so. A SERM is the way to go for PCT.
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    hey piston you forgot to let me know what that one of chicken's old posts? or was it new. Where is he at these days?
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    its an old one. I actuall copied it from another board members post that he had copied from superchicken so i dont actually know super, sorry bro. it was on mm.com (if you know where that is) i cant list link i think....
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    I've read this before, this is why i wanna stick with Aromasin or proviron for during a cycle.
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    is he saying to run these while cycling, or post cycle?
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    Quote Originally Posted by pistonpump
    its an old one. I actuall copied it from another board members post that he had copied from superchicken so i dont actually know super, sorry bro. it was on mm.com (if you know where that is) i cant list link i think....

    oh thats ok piston if its old i'm sure i've read it I actually helped chicken put together some of his first cycles lol i've been doing this too long. (mm) if that is where i think it is yeah i've known dream alot of years
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    Quote Originally Posted by mixedup
    Sorry to get off subject
    Is this a new post or old? I haven't seen superchicken in ages. he and I go way back I actually turned his view around on halotestin.
    I saw him MM a while back, I heard he still pops in once in a while.
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    Damn I remember Superchicken from the old fitnessboard.
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    Quote Originally Posted by pistonpump

    exemestane works differently. it does not stop the body from producing estrogen. rather, it makes it so the estrogen is unable to bind to receptors by deactivating the binding enzyme. if the estrogen cannot bind, you simply will not get bloated or get gyno. the estrogen is crippled due to exemestane. however, since the estrogen is still floating around, it will not negatively affect your lipid/cholesterol profile.
    Where does this idea come from? All I can find about it's mechanisme of action is the following :

    Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone. (FDA Label)

    Basically the same than any other AI.
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    Quote Originally Posted by Iron Warrior
    Damn I remember Superchicken from the old fitnessboard.
    Whoa then you must know CJwolf also.
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    Where does this idea come from? All I can find about it's mechanisme of action is the following :

    Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on adrenal biosynthesis of corticosteroids or aldosterone. (FDA Label)

    Basically the same than any other AI.
    That's what I thought. AI's are bad for lipids because they reduce estrogen, but provide no substitute for it in the liver. While SERMS are actually estrogen agonists, stimulating the production of HDL.

    I dont see how this information is valid...Id like to find out for sure though.

    BV
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    who has experience with running nolva on a bulk cycle? was wondering if 10mg a day would hurt gains?
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    Quote Originally Posted by pistonpump
    who has experience with running nolva on a bulk cycle? was wondering if 10mg a day would hurt gains?

    ran it alot on my test prop/dbol cycles loved it helped with bloat and I never noticed any lack of gains.
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    thanks for that mixedup

    aromasin is different from adex and letro. I can find references but im lazy it is somewhat the same but adex and letro act in the same way aromasin slightly different. adex and letro block the aromatase and aromasin makes aromatase unable to bind i think...same thing just the other way around. im still research AIs so i might be wrong. they seem more confusing when making a choice than actual gear. i guess one has to try a few and make his/her own decision what works best.
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    Quote Originally Posted by pistonpump
    I wouldnt think so. A SERM is the way to go for post cycle therapy.

    Bump. You can't create a homeostasis when estrogen is completely eradicated.
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    Quote Originally Posted by pistonpump
    thanks for that mixedup

    aromasin is different from adex and letro. I can find references but im lazy it is somewhat the same but adex and letro act in the same way aromasin slightly different. adex and letro block the aromatase and aromasin makes aromatase unable to bind i think...same thing just the other way around. im still research AIs so i might be wrong. they seem more confusing when making a choice than actual gear. i guess one has to try a few and make his/her own decision what works best.

    Type I inhibitors (like Aromasin) are actually steroidal compounds, while type II inhibitors (like Letro and A-dex) are non-steroidal drugs. Hence, androgenic side effects are very possible with Type-I AIs, and they should probably be avoided by women. Of course, there are some similarities between the two types of AIsÖboth type I & type II AIs mimic normal substrates (essentially androgens), allowing them to compete with the substrate for access to the binding site on the aromatase enzyme. After this binding, the next step is where things differ greatly for the two different types of AIís. In the case of a type-I AI, the noncompetitive inhibitor will bind, and the enzyme initiates a sequence of hydroxylation; this hydroxylation produces an unbreakable covalent bond between the inhibitor and the enzyme protein. Now, enzyme activity is permanently blocked; even if all unattached inhibitor is removed. Aromatase enzyme activity can only be restored by new enzyme synthesis. Now, on the other hand, competitive inhibitors, called type II AIís, reversibly bind to the active enzyme site, and one of two things can happen: 1.) either no enzyme activity is triggered or 2.) the enzyme is somehow triggered without effect. The type II inhibitor can now actually disassociate from the binding site, eventually allowing renewed competition between the inhibitor and the substrate for binding to the site. This means that the effectiveness of competitive aromatase inhibitors depends on the relative concentrations and affinities of both the inhibitor and the substrate, while this is not so for noncompetitive inhibitors. Aromasin is a type-I inhibitor, meaning that once it has done its job, and deactivated the aromatase enzyme, we donít need it anymore. Letrozole and Arimidex actually need to remain present to continue their effects.
  

  
 

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