Originally Posted by Ubiquitous
No, lipids= HDL, LDL... cholesterol... Estrogen and cholesterol have a nice little relationship that is born in the liver. A powerful AI such as Letro puts a chokehold on aromatase, thus slowing Estrogen conversion to a dead halt...everywhere.. Estrogen has many favorable effects in the body. I do like Letro, but if you're concerned about your lipid profile, there are better choices.
Exemestane is a steroidal AI that doesn't wreak havoc on your lipids or IGF levels.
Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe
Nemours Children’s Clinic and Research Programs (N.M., J.L., A.R.), Jacksonville, Florida 32207; and University of Florida Health Sciences Center (D.P.) and Amersham Pharmacia Biotech (E.d.S., A.K., B.L.), Peapack, New Jersey 07977
Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study.
This work was supported by a grant from Amersham Pharmacia Biotech.
Abbreviations: AUC, Area under the curve; CBC, cell blood count; HDL, high density lipoprotein; LDL, low density lipoprotein; PK, pharmacokinetic
It, and ATD (otc) are good in the fact that they don't cause a rebound once you cease use.
Keep your AI use to a minumum dose, as you should control, but not obliterate estrogen. Some AI's are more promising in terms of overall benefits than others.
SERMS are Selective Estrogen Receptor Modulators... ie: acts as an antogonist in breast tissue, but acts as an agonist in Liver, brain and other tissues.
Don't throw Tren of any sort in there. This is your first injectable cycle right?
Guage the results from the compounds you presented.. nothing more.. the idea is to use the lowest efficacious dose, not whip up a smorgasbord of a chemical c0cktail party, in which you can't tell what side is coming from what compound. Less is more... or rather, moderation. That thinking applies with so many things in life bro.
