If I can remember my differential equations from a long time ago and do a best quess intuitive estimation - which by the way I am very good at. I think BDC is quite correct at about 18 hours - so it is up to you whether you apply it once a day or twice a day. The DMSO would speed up the process and make it about 12 - 14 hours in my Scientific Wild Ass Guess Method that I learned from the school of life. I only learned hieroglyphics at the University of California.