Are you guys UNDER dosing NAC? (Study Included)

[IntensePump]

It seems as though there are vast variances in the doses of NAC that many members of the board are taking. According to an NAC study on Invalid Link Removed the following is stated:

"Recommended adult doses of NAC vary depending on the health condition being treated. The following list provides guidelines for the most common uses.

• Bronchial disease: 200 mg two times per day
• To improve HDL cholesterol: 1,200 to 3,600 mg per day
• Antioxidant protection/general health: 500 mg per day to start. Individuals may increase the dose up to 3,000 to 4,000 mg per day as tolerated."

Based on this information, when one is on Superdrol or other HDL damaging drug, a dose of at least 1200mg per day would be optimal.

Has anybody used NAC to help their HDL levels? If so, how were the results? Any other comments on this guys?

 

[ersatz]

It seems as though there are vast variances in the doses of NAC that many members of the board are taking. According to an NAC study on Invalid Link Removed the following is stated:

"Recommended adult doses of NAC vary depending on the health condition being treated. The following list provides guidelines for the most common uses.

• Bronchial disease: 200 mg two times per day
• To improve HDL cholesterol: 1,200 to 3,600 mg per day
• Antioxidant protection/general health: 500 mg per day to start. Individuals may increase the dose up to 3,000 to 4,000 mg per day as tolerated."

Based on this information, when one is on Superdrol or other HDL damaging drug, a dose of at least 1200mg per day would be optimal.

Has anybody used NAC to help their HDL levels? If so, how were the results? Any other comments on this guys?

NAC has been shown to act as a pro-oxidant at dosages above 2g/day. As for HDL, I don't think anyone just runs NAC so any results cannot be attirbuted to NAC, RYR, or poli.

 

[ersatz]

Failure of N-acetylcysteine to reduce low-density lipoprotein oxidizability in healthy subjects.

Kleinveld HA, Demacker PN, Stalenhoef AF.

Department of General Internal Medicine, University Hospital, Nijmegen, The Netherlands.

We have studied the effects of N-acetylcysteine, which is thought to have antioxidant properties, on the susceptibility of low-density lipoprotein to oxidation and on whole-blood glutathione concentrations in six healthy volunteers. N-acetylcysteine was given orally in a dosage of at 1.2 g per day for 4 weeks, followed by 2.4 g per day for a further two weeks. The susceptibility of low-density lipoprotein to in vitro Cu(2+)-oxidation was determined by continuously measuring the formation of conjugated dienes. Whole-blood concentrations of reduced and oxidized glutathione were also determined. N-acetylcysteine had no effect on the susceptibility of LDL to oxidation. Concentrations of vitamin E in the serum and in low-density lipoprotein were not changed. Compared with controls the concentration of glutathione in N-acetylcysteine treated subjects was reduced (-48%) and the concentration of oxidized glutathione was higher (+80%). The GSH/GSSG-ratio, a marker of oxidative stress was 83% lower. The results do not support the supposed antioxidative action of N-acetylcysteine. It seems more likely that N-acetylcysteine acts as a pro-oxidant in the dosage used.

 

[Iron Warrior]

Hey IP, I'm sure most of us use it for liver protection so those issues aren't a concern with NAC. I use 500 mg.

 

[IntensePump]

Hey IP, I'm sure most of us use it for liver protection so those issues aren't a concern with NAC. I use 500 mg.

IronWarrior,

I agree that many of us use it for liver protection. However, given the destruction of HDL cholesterol that Superdrol has on a human body, I'm wondering if using NAC at the apprpriate dosage would be worthwhile if it could increase HDL levels. However, according to another study listed above, perhaps there are cons that may outweight the possible pros.

 

[DR X]

I run NAC for liver protection along with other stuff and for the last 6 months have been doing 2000mg ED.
6 months ago my HDL was 37 Yesterday it was 62. NAC? I don't know.

 

[StanChampion]

I take 1gram post workout.

I try and take the mutli prong approach to anitoxidant each day. I never get sick and I train 5 days/week with 30 min cardio each day. No PH's right now either.
NAC
ALCAR
C
Green Tea
Multi vit.

 

[bioman]

Seems like a pretty nebulous supplement. This is one of the problems I have with us thinking that taking one supp will protect us from liver damage or whatever while on powerful androgens. Without monitoring blood work weekly there's just no way to know.

For liver protection it seems (emphasis on "seems") like KR-ALA is a more reliable way to go. Maybe in conjunction with 500mg of NAC? Who knows and it's going to vary a lot person to person.

NAC and LDL levels are probably tied closely with a person's ambient homocysteine levels, how much B6/B12/folic acid/selenium they're getting as well as a host of other factors I'm totally ignorant of.

The drop in lipid values while on SD or M1T is IMO, the result of the liver hording it's lipid supplies as it is under a toxic exposure. This has the effect of crashing HDL levels to dangerous lows and I think this a bigger threat than liver values themselves given the recommended short duration of SD/M1T exposure. This of course would change if a person stayed on either compound for a long period or under high doses.

Bottom line..don't depend on a supplement to magically protect you from extremely powerful and toxic androgens. Keeping your cycles short and methyl use infrequent (once per year) is the only sure fire way to protect yourself..that and avoiding methyls altogether

 

[SJA]

I've always dosed it at 1200mg X 2. It's cheap enough and why take any chances underdosing?

 

[Syr]

I've always dosed it at 1200mg X 2. It's cheap enough and why take any chances underdosing?

Because NAC becomes pro-oxidant above 1800-2000mg per day.

 

[SJA]

Because NAC becomes pro-oxidant above 1800-2000mg per day.

I see conflicting info here. Where did you see that Syr? The only side effect that I can find is zinc and copper depletion with long term use. Supplement watch even states that you could consume 60-80G/day without severe adverse reactions.