Pax
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This was sent to me via email from a friend who owns a nutrition store:
Technical Brief for 2-Ene Steroidal Compounds for Sale as Food Supplements
Written & Edited By:
Bruce W. Kneller
Name of compound(s): 5alpha-androst-2-en-17-one;
5alpha-androst-2-en-17beta-ol
Alternate nomenclature(s): 17-keto-2-etioallocholene;
17b-hydroxy-2-etioallocholene
Brief: 17-keto-2-etioallocholene (Pheromone 1) and 17b-hydroxy-2-etioallocholene (Pheromone 2) are naturally occurring, oestrous-related pheromonones of the female Asian elephant (Elephas maximus) that are known to induce behavioral responses in elephant bulls (Reproduction. 2001 Mar;121(3):475-84). Neither compound is known to be found naturally in primates, including humans although Pheromonone 1 could possibly be found naturally on human skin as it is a potential, metabolic by-product of dehydroepiandrosterone degradation when incubated with human axillary bacterial isolates in various culture media (J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):81-9).
Currently, neither Pheromonone 1 or 2 are federally scheduled as C-III or considered “anabolic steroids� at the Federal or any State level.
It is clear that Pheromonone I and Pheromonone II are chemically unrelated to testosterone for the following reasons –
Although a synthetic, carbon #17 alpha-alkylated analog to Pheromonone 1 (17alpha-methyl-5alpha-androst-2-en-17beta-ol aka “Madol�) was found by the World Anti-Doping Agency in Montreal and The UCLA lab and the Doping Control Laboratory of Athens recently and labeled a “Designer Steroid�, this is clearly a synthetic analog to the Pheromonone I and has, chemical, pharmacological and pharmacokinetic properties that are unique and significantly different than Pheromonone 1 and Pheromonone 2.
Clearly, although chemically ‘related’ to Madol or methylandrostenol, Pheromonone 1 and Phermone 2 are distinctly different in that they are naturally occurring and are likely to be far less hepatotoxic because they both lack the carbon #17 alpha-alkylation that Madol possesses. It is unlikely that Pheromome 1 and Pheromonone 2 will have the same hepatic metabolites as Madol for this reason also.
Madol, which was first reported in a patent in 1961, was shown to have high anabolic (muscle-building) effects, but it was never approved for use and has not been widely studied since that time. It is possible that Pheromonone 1 and Pheromonone 2, if administered to humans in high enough dosages, might impart a similar, high anabolic effect but this has not been clearly proven or demonstrated in any clinical study to date ever.
Pheromonone 1 and Pheromonone 2 are clearly be legal to sell as dietary supplements in the United States because of the information demonstrated in this brief. Both compounds are clearly naturally occurring and found in food stuffs (elephants). Neither has ever been characterized as an anabolic steroid or controlled substance by any Federal or State agency to date. Neither compound is chemically related to testosterone and neither compound has been proven to be anabolic in humans to date.
Pheromonone 1 and Pheromonone 2 have been demonstrated to cause or induce certain behavioral patterns in Asian bull elephants. It is also possible that these compounds might impart the same effect(s) in humans but this has yet to be proven. It is also possible that many people might find these potential effects to be desirable and positive.
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Interesting article. I have not given it much thought, other than I am perplexed as to whether this is simply a re-formulation of Novedex XT or some new product. Will do the research on it later. Comments? Now that I think about it... this may not even reference a new product, but may actually just be discussing Novedex XT.... beats me....
Technical Brief for 2-Ene Steroidal Compounds for Sale as Food Supplements
Written & Edited By:
Bruce W. Kneller
Name of compound(s): 5alpha-androst-2-en-17-one;
5alpha-androst-2-en-17beta-ol
Alternate nomenclature(s): 17-keto-2-etioallocholene;
17b-hydroxy-2-etioallocholene
Brief: 17-keto-2-etioallocholene (Pheromone 1) and 17b-hydroxy-2-etioallocholene (Pheromone 2) are naturally occurring, oestrous-related pheromonones of the female Asian elephant (Elephas maximus) that are known to induce behavioral responses in elephant bulls (Reproduction. 2001 Mar;121(3):475-84). Neither compound is known to be found naturally in primates, including humans although Pheromonone 1 could possibly be found naturally on human skin as it is a potential, metabolic by-product of dehydroepiandrosterone degradation when incubated with human axillary bacterial isolates in various culture media (J Steroid Biochem Mol Biol. 1997 Sep-Oct;63(1-3):81-9).
Currently, neither Pheromonone 1 or 2 are federally scheduled as C-III or considered “anabolic steroids� at the Federal or any State level.
It is clear that Pheromonone I and Pheromonone II are chemically unrelated to testosterone for the following reasons –
- Testosterone is saturated in the A-ring at carbon # 4 while Pheromonone 1 and 2 are saturated in the A-ring at carbon #2.
- Testosterone is aromatizable to various estrogens in the human body by the CYP class of enzymes found in humans while Pheromonone I and II can not be converted to estrogens by humans because they are already reduced fully at carbon # 5.
- Testosterone also has a ketone functional group at carbon # 3 in the A-ring while Pheromonone 1 and Pheromonone 2 do not have any functional group attachments anywhere in the A-ring.
- Additionally, testosterone is formed endogenously in humans by the metabolization of androstenedione. Neither Pheromonone 1 or Pheromonone 2 is formed endogenously in any primates, including humans.
Although a synthetic, carbon #17 alpha-alkylated analog to Pheromonone 1 (17alpha-methyl-5alpha-androst-2-en-17beta-ol aka “Madol�) was found by the World Anti-Doping Agency in Montreal and The UCLA lab and the Doping Control Laboratory of Athens recently and labeled a “Designer Steroid�, this is clearly a synthetic analog to the Pheromonone I and has, chemical, pharmacological and pharmacokinetic properties that are unique and significantly different than Pheromonone 1 and Pheromonone 2.
Clearly, although chemically ‘related’ to Madol or methylandrostenol, Pheromonone 1 and Phermone 2 are distinctly different in that they are naturally occurring and are likely to be far less hepatotoxic because they both lack the carbon #17 alpha-alkylation that Madol possesses. It is unlikely that Pheromome 1 and Pheromonone 2 will have the same hepatic metabolites as Madol for this reason also.
Madol, which was first reported in a patent in 1961, was shown to have high anabolic (muscle-building) effects, but it was never approved for use and has not been widely studied since that time. It is possible that Pheromonone 1 and Pheromonone 2, if administered to humans in high enough dosages, might impart a similar, high anabolic effect but this has not been clearly proven or demonstrated in any clinical study to date ever.
Pheromonone 1 and Pheromonone 2 are clearly be legal to sell as dietary supplements in the United States because of the information demonstrated in this brief. Both compounds are clearly naturally occurring and found in food stuffs (elephants). Neither has ever been characterized as an anabolic steroid or controlled substance by any Federal or State agency to date. Neither compound is chemically related to testosterone and neither compound has been proven to be anabolic in humans to date.
Pheromonone 1 and Pheromonone 2 have been demonstrated to cause or induce certain behavioral patterns in Asian bull elephants. It is also possible that these compounds might impart the same effect(s) in humans but this has yet to be proven. It is also possible that many people might find these potential effects to be desirable and positive.
___________________________________________
Interesting article. I have not given it much thought, other than I am perplexed as to whether this is simply a re-formulation of Novedex XT or some new product. Will do the research on it later. Comments? Now that I think about it... this may not even reference a new product, but may actually just be discussing Novedex XT.... beats me....
