jverch
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i know its good for cholesterol support, but would u take while on or after SD cycle or both?
RYR mostly helps lipids by reducing LDL, it is unlikely to affect (raise) your HDL much. The ultimate dose will depend upon the particular extract, many of them are standardized to a particular concentration of mevilonins (the HMGA-COA reductase inhibitory agents found in RYR, they are statins). As with any statin containing drug, RYR can deplete COQ10. Statins also, although very rarely and probably more typical of stronger statins at higher doses, cause liver enzymes to elevate and also are known to cause myopathy. Again, the data for lovastain (mevacor, the primary statin in RYR) indicates a very, very low incidence of these effects but one should always keep this in mind when taking them in case you are the one in a million with a problem. Also, do not take grape fruit or grapefruit juice, or any other drug (such as ketoconazole) which can inhibit CYP-3A4, as this can cause plasma levels of the mevilonins to go through the roof, with a much increased risk of side effects.i know its good for cholesterol support, but would u take while on or after SD cycle or both?
Check out the link below, and keep in mind that Lovastatin is the USAN (generic) name for mevacor which is considered the main active statin in RYR. As you read down until you see the graphical representation of drug-lovastatin interaction, the blood plasma level of lovastatin (again, mevacor) can get up to 20 times its non-interacted levels. Mevacor at low doses (10-20 mg) has shown itself to be pretty damn safe, but if it is present at 20 times its low dose concentration level, the incidences of myopathy (muscle wasting) are likely to approach very unacceptable rates. Read the whole link I included, it is quite informative and I think would answer your questions very well. As far as the ASR dhb, it is likely a strong CYP-3A4 inhibitor and thus, I would think, a definite no-no with any statin. Also, I am not sure what dose of SD you plan on taking....I personally would caution against making the asr dhb/SD combination in any event....SD is 17-alpha methylated and thus resistant to hepatic breakdown, by inhibiting your drug-metabolizing enzymes in the liver, there really is no predicting how high the SD levels will get, and where SD is already a fairly risky proposition in terms of liver/lipid effects; the combination has the potential to exponentially increase your risk. But of course, thats JMHO and I do wish you the best of luck!Chucky i planned on taking asr dhb it says it inhibits CYP
also planned to take ryr for a 3-4 week superdrol cycle. you said
this can cause plasma levels of the mevilonins? to go through
the roof, with a much increased risk of side effects. What
side effects would this increase. thanks for the help.
Twin. Loki, Sledge, ALR......can somobody translate this into "brotelligence"??? (just kidding, Strat! )Check out the link below, and keep in mind that Lovastatin is the USAN (generic) name for mevacor which is considered the main active statin in RYR. As you read down until you see the graphical representation of drug-lovastatin interaction, the blood plasma level of lovastatin (again, mevacor) can get up to 20 times its non-interacted levels. Mevacor at low doses (10-20 mg) has shown itself to be pretty damn safe, but if it is present at 20 times its low dose concentration level, the incidences of myopathy (muscle wasting) are likely to approach very unacceptable rates. Read the whole link I included, it is quite informative and I think would answer your questions very well. As far as the ASR dhb, it is likely a strong CYP-3A4 inhibitor and thus, I would think, a definite no-no with any statin. Also, I am not sure what dose of SD you plan on taking....I personally would caution against making the asr dhb/SD combination in any event....SD is 17-alpha methylated and thus resistant to hepatic breakdown, by inhibiting your drug-metabolizing enzymes in the liver, there really is no predicting how high the SD levels will get, and where SD is already a fairly risky proposition in terms of liver/lipid effects; the combination has the potential to exponentially increase your risk. But of course, thats JMHO and I do wish you the best of luck!
http://www.ajmc.com/Article.cfm?Menu=1&ID=2783
Eshamed, many have reported significant anabolic effects of SD by itself at low doses. I think as a general rule, unless you have convincing experience otherwise, would be to start off at the lowest dose SD (10mg) without the dhb. If it is the case that you have a strong rationale for needing more SD on board, then you could even take a higher dose. The problem, in my mind, with adding dhb into the mix is that you simply cannot predict how this will effect your exposure to SD. Since SD is already a risky proposition (as are most if not all 17-methyl steroids), I would be very cautious about introducing another unknown variable into the mix, particularly one that has the potential to multiply any complications. Also, if you really want to get a better idea how SD is personally affecting your physiology, you would be best to have baseline and end of cycle bloodwork completed, paying special attention to liver enzymes and lipids. I imagine that proliver and garlic would not be bad, but I would liken them to whistling past a graveyard, it might make you feel better but truth be told, your enzymes and lipids are still likely to get way skewed and the primary purpose of the bloodwork is so that you will better understand your own personal response to the SD. Since some people get hit way harder than others (although I do believe everybody gets hit!), it is best to know which end of the spectrum you lie on...you might want that information for future reference. Hey, best of luck to you!Chucky i already bought the dhb so what do you think
of weeks 1-2 10mg with the dhb then weeks 3-4 20mg if
i need it but still only 1 dhb and will stop the dhb a few days before
pct. Also have pro liver and NOW garlic and Hawthorne Berry and will
buy NOW Cholesterol Support if thats ok for the cycle?. Then when
I start pct start ryr and keep taking the chol. support.
Thanks for your help.
Just to be clear, I don't think RYR is a bad idea on cycle, I just wish to caution against using a statin (or statin containing substance) together with substances that inhibit CYP-3A4. As as for your results, S.Norman, its hard to argue with success! I would say it is possible that there are other substances in RYR that lower cholesterol, but I don't see much evidence for RYR by itself raising HDL. One thing about statins that has always piqued my interest is their ability to lower c-reactive protein (CRP), a marker of inflammation. This marker is probably more predictive of heart attacks then LDL, and statins, I believe, show an across the board ability to decrease its levels. Of course correlation is not causation and thus decreasing one may not affect the other, but it certainly is interesting nevertheless!i have heard that there are other chems in ryr that lower chol and raise hdl. lovastatin is just one of them. anecdotal evidence (many users on this board) points clearly that ryr lowers chol on cycle. as for me, my total chol can reach 275 on cycle. w/ ryr 2.4g eod, my chol was 190 and hdl was close to normal-not in single digits like it usually is.
I'll add a quick second to the "RYR Worked For Me" group.i have heard that there are other chems in ryr that lower chol and raise hdl. lovastatin is just one of them. anecdotal evidence (many users on this board) points clearly that ryr lowers chol on cycle. as for me, my total chol can reach 275 on cycle. w/ ryr 2.4g eod, my chol was 190 and hdl was close to normal-not in single digits like it usually is.
Damn, that is pretty impressive. You said 1200 mg RYR, was it an extract, and if so what was it standardized to?I'll add a quick second to the "RYR Worked For Me" group.
Week 4 of M1T without RYR HDL=7, LDL=181 (201 total)
Week 6 of M1T with 1200mg RYR HDL=44, LDL=118 (172 total)
I can add more detail if anyone has specific questions.
Bottom line for me was that it worked, to a significant degree.
Whoops! I had my dosage wrong above, I should have added 2x daily, so it was 2400mg/day. I take the NOW brand and they describe it on the link below as:Damn, that is pretty impressive. You said 1200 mg RYR, was it an extract, and if so what was it standardized to?
I got 3 blisters of Allimax for my next SD cycle to use in place of RYR. I'll probably have bloodtests again.I've thougth about trying alicin (sp?) the active ingredient in garlic, I believe. But, since "Hooked on Phonics/RYR worked for me!" and my latest results were so good, I probably will stick with just the RYR/CoQ10. What brand policosanol did you get? I thought I had searched that site and couldnt find it. Thanks.
RYR will reduce CRP within the first day but lipid lowering effects weren't seen until the 14th day. Poli on the other hand appears to take about a month to "kick in" but it also improves HDL whereas results with RYR are mixed with regards to HDL. Niacin and a slew of other supps reduce lipid levels as well. Niacin seems to take some time, several months I believe for full effects to be realized, which would make it ideal to run year round.I got 3 blisters of Allimax for my next SD cycle to use in place of RYR. I'll probably have bloodtests again.
What i heard about policosanol is that is effective, but that must be taken all year round, not like a quick fix, unline RYR.
is there any truth to the idea that niacin and RRY should NOT be used together???RYR will reduce CRP within the first day but lipid lowering effects weren't seen until the 14th day. Poli on the other hand appears to take about a month to "kick in" but it also improves HDL whereas results with RYR are mixed with regards to HDL. Niacin and a slew of other supps reduce lipid levels as well. Niacin seems to take some time, several months I believe for full effects to be realized, which would make it ideal to run year round.
No, I don't think there would be any extra special cause for concern since niacin and statins are routinely combined for people who need to lower LDL, and raise HDL (and lower triglycerides) at the same time. In this regard, the combination would be predicted to be very complementary. In fact, Advicor (sic?) is a prescription combination of niaspan and lovastatin. Both do have some baggage, for example, Niacin can adversely affect the liver (like everything else, it seems) but instant release, niapan or inositol hexniaciniate do not appear to be too bad in this regard, it appears some of the older sustained release formulations were especially problematic. I think there have also been some reports of rhabdomyolysis in people taking statins with niacin, but since statins themselves can cause this, it is not clear if the combination is any worse. One would think that reasonable doses of RYR (which contains plustever else in there) together with niacin (but not old-controlled release) would provide very significant cardo-benefit...but of course, thats JMHO! I'e been looking into getting some niacin to go with my RYR....is there any truth to the idea that niacin and RRY should NOT be used together???
I think I'll check that out, thanks!I would use inositol hexaniacinate over niacin only because it doesn't cause flushing. There are a number of studies where people use statins and 3-5g of niacin without too many adverse reactions. Niacin can impair glucose tolerance at high those doses though. Ino hex can be taken at 1500mg/day without the flushing, glucode tolerance issues and other negatives associated with high doses of niacin.
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