Clomiphene citrate is safe and effective for long-term management of hypogonadism

[BeastFitness]

Clomiphene citrate is safe and effective for long-term management of hypogonadism.

OBJECTIVE:
To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG).

PATIENTS AND METHODS:
Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) results were collected for all patients. Demographic, comorbidity, treatment and Androgen Deficiency in Aging Men (ADAM) score data were also recorded. Comparison was made between baseline and post-treatment variables, and multivariable analysis was conducted to define predictors of successful response to CC. The main outcome measures were predictors of response and long-term results with long-term CC therapy in hypogonadal patients.

RESULTS:
The 46 patients (mean age 44 years) had baseline serum testosterone (T) levels of 228 ng/dL. Follow-up T levels were 612 ng/dL at 1 year, 562 ng/dL at 2 years, and 582 ng/dL at 3 years (P < 0.001). Mean femoral neck and lumbar spine BD scores improved significantly. ADAM scores (and responses) fell from a baseline of 7 to a nadir of 3 after 1 year. No adverse events were reported by any patients.

CONCLUSIONS:
Clomiphene citrate is an effective long-term therapy for HG in appropriate patients. The drug raises T levels substantially in addition to improving other manifestations of HG such as osteopenia/osteoporosis and ADAM symptoms.


Clomiphene citrate is safe and effective for long-term management of hypogonadism. - PubMed - NCBI

 

[BamBam0319]

alexb13

 

[BRUstrong]

I've been on it for TRT since 2013 with great results and no sides. I was at 50mg EOD but my test was high for therapeutic range (about 850 - I'm 32) so they bumped me down to 25mg EOD.

The reason behind putting me on clomid was to maintain fertility so my wife and I could have kids. We just had twins (so it worked) but due to complications she had to have a hysterectomy so our baby-making days are over. I told my doc that he could switch me over to test if he wanted, as fertility is no longer a concern, but he kept me on clomid due to how well it was working

 

[criticalbench]

I've always read this does very little for male fertility though.. good info.

 

[BRUstrong]

I've always read this does very little for male fertility though.. good info.

I should have clarified - I didn't have issues with fertility, but going on test would have likely caused major infertility issues. So my doctor (urologist at the Cleveland Clinic) put me on Clomid to boost test (I had three labs all under 250 before starting) and maintain fertility.

I don't know of any studies that suggest Clomid increases fertility in males